mGluR8 / GRM8 antibody

Principal name

mGluR8 / GRM8 antibody

Alternative names for mGluR8 / GRM8 antibody

Metabotropic glutamate receptor 8, GPRC1H

SwissProt ID

O00222 (Human), P47743 (Mouse), P70579 (Rat)

Gene ID

2918 (GRM8), 42918 (nAcRalpha-96Aa), 60590 (Grm8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Por (Porcine), Rb (Rabbit), Can (Canine), Chk (Chicken), Hst (Hamster)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of mGluR8 / GRM8 antibody

Metabotropic glutamate receptors (mGluRs), heptahelical transmembrane receptors coupled to G-proteins, contribute to the regulation of neurol excitability and syptic transmission. Genes coding for eight mGluRs (denoted mGluR1-8) with different splice variants have been identified and classified into three groups based on sequence homology, pharmacology, and sigling pathways. Group I mGluRs (mGluR1 and mGluR5) are primarily located postsyptically. Group II (mGluR2 and mGluR3) are present both postsyptically and presyptically outside the release site. Group III mGluRs (mGluR4, mGluR6, mGluR7, and mGluR8) couple to Gai/o to inhibit adenylyl cyclase found in the presyptic active zone. The mGluR8 receptor is detected in the olfactory bulb, thalamus, pontine gray, cerebral cortex, hippocampus, cerebellum, and reti. Electrophysiological studies suggest that mGluR8 functions as a presyptic autoreceptor to regulate glutamate release from the lateral perforant path termils in the mouse dentate gyrus. It is suggested that mGluR8, like other group III mGluRs, controls glutamate release by inhibiting voltage-gated Ca2+ channels. Targeted deletion of the mGluR8 gene in mice produces subtle behavioral alterations such as reduced habituation to novelty, hyperactivity, context-dependent but not cue-dependent disruption of the freezing response in the fear conditioning test, and increased anxiety.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

mGluR8 / GRM8 antibody

  Rabbit polyclonal anti-GluR8 antibody  
Western blot analysis of extracts from mouse brain, using GluR8 antibody (#TA313976).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR8 / GRM8 antibody

  Anti-GRM8 Rabbit Polyclonal Antibody  
Predicted band size: 56 kDa . Positive control: Mouse heart tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/1500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR8 / GRM8 antibody

  Rabbit anti-GRM8 Polyclonal Antibody  
Western blot analysis of extracts of mouse brain tissue, using GRM8 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

mGluR8 / GRM8 antibody

  Rabbit Polyclonal Anti-mGluR8 (extracellular)  
Western blot analysis of rat brain membranes (lanes 1 and 4), mouse brain membranes (lanes 2 and 5) and human SH-SY5Y neuroblastoma cell line lysate (lanes 3 and 6): 1-3. Anti-mGluR8 (extracellular) antibody, (1:400). 4-6. Anti-mGluR8 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

mGluR8 / GRM8 (N-term) antibody

  Rabbit Polyclonal Anti-GRM8 Antibody (N-Terminus)  
mGluR8 / GRM8 Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

mGluR8 / GRM8 (C-term) antibody

  Rabbit Polyclonal Anti-GRM8 Antibody (C-Terminus)  
mGluR8 / GRM8 Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

mGluR8 / GRM8 antibody

  Rabbit Polyclonal Anti-mGluR8 Antibody  
Western blot analysis on mouse brain cell lysate using mGluR8 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

mGluR8 / GRM8 antibody

  Rabbit Polyclonal Anti-GluR8 Antibody  
Western blot analysis of GluR8 expression in Mouse brain extract Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

mGluR8 / GRM8 antibody

Immunohistochemistry (IHC) analyzes of mGluR8 antibody (Cat.-No.: AP06143PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

mGluR8 / GRM8 (C-term) antibody

The GRPRC1H C-term (AP11647PU-N) is used in Western blot to detect GRPRC1H in mouse brain tissue lysate. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

mGluR8 / GRM8 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mGluR8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

mGluR8 / GRM8 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mGluR8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

GRM8 - human gene knockout kit via CRISPR

GRM8 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GRM8 - human gene knockout kit via CRISPR

GRM8 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRM8 - human gene knockout kit via CRISPR

GRM8 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRM8 - human gene knockout kit via CRISPR

GRM8 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GRM8 overexpression lysate

GRM8 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

GRM8 overexpression lysate

GRM8 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GRM8 (mGFP-tagged) - Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, GRM8 (mGFP-tagged) - Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, GRM8 (Myc-DDK tagged) - Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, GRM8 (Myc-DDK tagged) - Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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