MHC Class I (RT1Aa) antibody
Principal name
MHC Class I (RT1Aa) antibody
Alternative names for MHC Class I (RT1Aa) antibody
RT1 class I histocompatibility antigen AA alpha chain
SwissProt ID
P16391 (Rat)
Ncbi ID
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F), Enzyme Immunoassay (E), Paraffin Sections (P)
Background of MHC Class I (RT1Aa) antibody
MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.
General readings
1. Fukumoto, T. et al. (1982). Mouse monoclonal antibodies against rat major histocompatibility antigens. Two Ia antigens and expression of Ia and Class I antigens in rat thymus. Eur. J. Immunol. 12: 237-243.
2. Bukovsky, A., et al. (1984). Association of some cell surface antigens of lymphoid cells and cell surface differentiation antigens with early rat pregnancy. Immunology. 52:631-640
3. Osawa, H. et al. (1985). Inhibin of IL-2 dependent proliteration of rat T-lymphoblast by the monoclonal antibody ART62 which reacts with MHC class I antigens.
J. Immunol. 134(6): 3901-3906.
4. Stet, R.J.M. et al. (1987). U9F4: A monoclonal antibody recognizing a rat polymorphic class I determinant.
Transpl. Proc. 19: 3004-3005.
5. Fujikawa, L. S. et al. (1989). Class Ii antigens on retinal vascular endothelium, pericytes, macrophages and lymphocytes of the rat.
Invest. Ophthalmol. Vis. Sci. 30(1): 66-73
6. Zhai, Y. and Knechtle, S. et al. (1998). Two distinct forms of soluble MHC class II molecules synthesized by different mechanisms in normal rat cell in vitro.
Human Immunol. 59: 404-414
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| SM310 | MHC Class I (RT1Aa) (polymorphic) antibody |
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 |
Rat | IgG2a | R2/15S | Supernatant | Rt | F |
5 ml /
€330.00
|
| Acris Antibodies GmbH | |||||||
| SM311A | MHC Class I (RT1Aa) antibody |
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 |
Mouse | IgG1 | OX-18 | Azide Free | Rt | C, F, IP |
1 mg /
€620.00
|
| Acris Antibodies GmbH | |||||||
| SM311F | MHC Class I (RT1Aa) antibody |
||||||
 |
Mouse | IgG1 | OX-18 | FITC | Rt | F |
0.1 mg /
€430.00
|
| Acris Antibodies GmbH | |||||||
| SM311P | MHC Class I (RT1Aa) antibody |
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|
Mouse | IgG1 | OX-18 | Purified | Rt | C, F, IP |
0.25 mg /
€430.00
|
| Acris Antibodies GmbH | |||||||
| SM311PS | MHC Class I (RT1Aa) antibody |
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|
Mouse | IgG1 | OX-18 | Purified | Rt | C, F, IP |
0.1 mg /
€270.00
|
| Acris Antibodies GmbH | |||||||
| SM311PX | MHC Class I (RT1Aa) antibody |
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|
Mouse | IgG1 | OX-18 | Purified | Rt | C, F, IP |
1 mg /
€750.00
|
| Acris Antibodies GmbH | |||||||
| SM2206P | MHC Class I (RT1Aa) antibody |
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|
Mouse | IgG1 | F16-4-4 | Purified | Rt | C, F |
0.25 mg /
€430.00
|
| Acris Antibodies GmbH | |||||||
