MIB1 antibody

Principal name

MIB1 antibody

Alternative names for MIB1 antibody

E3 ubiquitin-protein ligase MIB1, DIP1, KIAA1323, ZZANK2, Mind bomb homolog 1, DAPK-interacting protein 1, Zinc finger ZZ type with ankyrin repeat domain protein 2

SwissProt ID

Q80SY4 (Mouse), Q86YT6 (Human)

Gene ID

57534 (MIB1)

Available reactivities

Hu (Human), Dros (Drosophila), Ms (Mouse), Rt (Rat), Xen (Xenopus), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP)

Background of MIB1 antibody

MIB1 is a 1006 amino acid E3 ubiquitin ligase that activates the Notch ligand, Delta. MIB1 ubiquinates Delta by binding to its intracellular domain, leading to the endocytosis and eventual degradation of the Delta receptor, which, paradoxically, results in the up-regulation of receptor activity and enhances Notch signaling. MIB1 also interacts with DAPK, a protein that plays an important role in the regulation of apoptosis. Ubiquination of DAPK leads to inhibition of caspase-dependent apoptosis, therefore it is likely that overexpression of MIB1 can lead to tumor growth. Although it seems to be widely expressed at low levels, MIB1 is expressed at highest concentrations in the CNS and ovary. Both DAPK and MIB1 are overexpressed in epileptic brain tissue, suggesting that they probably cooperate as regulators of neuronal death in epilepsy.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MIB1 (N-term) antibody

MIB Antibody (K28) (Cat. #TA324713) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MIB antibody detected the MIB protein (arrow). Rabbit Ig Purified Hu ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

MIB1 antibody

Western blot analysis of MIB1 in A431 cell lysate with MIB1 antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MIB1 antibody

MIB1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MIB1 antibody

MIB1 Mouse IgG2a 3E10 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

MIB1 antibody

Detection limit for recombinant GST tagged MIB1 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 2A9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

MIB1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with MIB1 polyclonal antibody ( Cat # PAB1726 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, ICC/IF, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

MIB1 antibody

Mib1/Mindbomb Antibody [NBP1-18308] - Polyclonal Antibody to E3 ubiquitin-protein ligase mind-bomb (MIB)  From rabbit.   IMMUNOGEN: Synthetic peptide derived from Nter domain of Drosophila melanogaster (Fruit fly) MIB.   SPECIFICITY: Reacts with Drosophila melanogaster 130 kDa MIB protein. APPLICATION: IHC, WB Rabbit Serum Dros P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

MIB1 antibody

Immunohistochemistry-Paraffin: Mib1/Mindbomb Antibody [NBP1-85210] - Immunohistochemical staining of human hippocampus shows moderate cytoplasmic positivity in neuronal cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

MIB1 antibody

Immunohistochemistry-Paraffin: Mib1/Mindbomb Antibody (EPR2762(2)) [NBP1-95846] human kidney tissue using anti-MIB1. Rabbit EPR2762(2) Purified Hu, Ms C, ICC/IF, IP, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MIB1

MIB1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MIB1

MIB1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MIB1

MIB1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MIB1 overexpression lysate

MIB1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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