MIC-B antibody

Principal name

MIC-B antibody

Alternative names for MIC-B antibody

MICB, PERB11.2, MHC class I polypeptide-related sequence B

SwissProt ID

Q29980 (Human)

Gene ID

4277 (MICB)

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (capture) (E(capture)), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of MIC-B antibody

MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is expressed on NK (Natural Killer) cells, NKT cells, T cells and CD8+T cells. Recognition of MICA and MICB by NKG2D is involved in tumor surveillance, immune responses to viral infections and autoimmune diseases. MICA and MICB are transmembrane glycoproteins that are distantly related to the MIC proteins, and they possess three extra-cellular Ig-like domains. And thus, MICA and MICB are closely related but are functionally indistinguishable. MICA and MICB molecules are highly glycosylated, and are detected as a smear band ranging from 65-75 kDa. It is reported that MICA and MICB are highly expressed in variant tumor cells, whereas normal cells express little. Tumor cells have been shown to shed and release MIC molecules from the cell surface. Therefore determination of soluble MIC (sMIC) levels provides valuable information for cancer staging, and sMIC in serum seems to be an indicator for systemic manifestation of malignancy rather than for local tumor extent.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MIC-B antibody

  Mouse Monoclonal anti-MICA/MICB Antibody  
Human Hela cell line stained with purified 6D4, followed by anti-mouse IgG FITC Mouse 6D4 Purified Hu F, P
0.1 mg / €248.00
  OriGene Technologies, Inc.

MIC-B antibody

Flow cytometric analysis of MICB expression on 293T cells (left) and Jurkat cells (right). Open histograms indicate the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26572AF-N to the cells. Mouse IgG1 BMO1 Azide Free Hu E, E(capture), F
0.1 mg / €370.00
  Acris Antibodies GmbH

MIC-B antibody

A typical Flow Cytometry staining pattern using Cat. No. AM31285AF-N, clone  B-D54 on Molt4 cell line (human acute lymphoblastic leukemia cell line) Mouse IgG1 B-D54 Azide Free Hu F
0.2 mg / €270.00
  Acris Antibodies GmbH

MIC-B antibody

A typical staining pattern with the B-D54 monoclonal antibody on Molt4 cell line Mouse IgG1 B-D54 FITC Hu F
1ml (100 Tests) / €270.00
  Acris Antibodies GmbH

MIC-B antibody

MIC-B Mouse IgG1 B-D54 PE Hu F
1ml (100 Tests) / €290.00
  Acris Antibodies GmbH

MIC-B antibody

MIC-B Mouse IgG1 B-D55 Azide Free Hu
0.2 mg / €270.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MICB - human gene knockout kit via CRISPR

MICB - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MICB - human gene knockout kit via CRISPR

MICB - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MICB - human gene knockout kit via CRISPR

MICB - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MICB - human gene knockout kit via CRISPR

MICB - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

ELISA Kits

Catalog No.    

Human MICB ELISA Kit

Human MICB ELISA Kit  
1 kit / €400.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MICB (mGFP-tagged) - Human MHC class I polypeptide-related sequence B (MICB), 200 uL, >10^7 TU/mL

Lenti ORF particles, MICB (mGFP-tagged) - Human MHC class I polypeptide-related sequence B (MICB), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, MICB (Myc-DDK tagged) - Human MHC class I polypeptide-related sequence B (MICB) , 200 uL, >10^7 TU/mL

Lenti ORF particles, MICB (Myc-DDK tagged) - Human MHC class I polypeptide-related sequence B (MICB) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

13 Item(s)

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