MIC-B antibody

Principal name

MIC-B antibody

Alternative names for MIC-B antibody

MICB, PERB11.2, MHC class I polypeptide-related sequence B

SwissProt ID

Q29980 (Human)

Gene ID

4277 (MICB)

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (capture) (E(capture)), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of MIC-B antibody

MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is expressed on NK (Natural Killer) cells, NKT cells, T cells and CD8+T cells. Recognition of MICA and MICB by NKG2D is involved in tumor surveillance, immune responses to viral infections and autoimmune diseases. MICA and MICB are transmembrane glycoproteins that are distantly related to the MIC proteins, and they possess three extra-cellular Ig-like domains. And thus, MICA and MICB are closely related but are functionally indistinguishable. MICA and MICB molecules are highly glycosylated, and are detected as a smear band ranging from 65-75 kDa. It is reported that MICA and MICB are highly expressed in variant tumor cells, whereas normal cells express little. Tumor cells have been shown to shed and release MIC molecules from the cell surface. Therefore determination of soluble MIC (sMIC) levels provides valuable information for cancer staging, and sMIC in serum seems to be an indicator for systemic manifestation of malignancy rather than for local tumor extent.

16 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MIC-B antibody

Flow cytometric analysis of MICB expression on 293T cells (left) and Jurkat cells (right). Open histograms indicate the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26572AF-N to the cells. Mouse IgG1 BMO1 Azide Free Hu E, E(capture), F
0.1 mg / €360.00
  Acris Antibodies GmbH

MIC-B antibody

A typical Flow Cytometry staining pattern using Cat. No. AM31285AF-N, clone  B-D54 on Molt4 cell line (human acute lymphoblastic leukemia cell line) Mouse IgG1 B-D54 Azide Free Hu F
0.2 mg / €270.00
  Acris Antibodies GmbH

MIC-B antibody

A typical staining pattern with the B-D54 monoclonal antibody on Molt4 cell line Mouse IgG1 B-D54 FITC Hu F
1ml (100 Tests) / €270.00
  Acris Antibodies GmbH

MIC-B antibody

MIC-B Mouse IgG1 B-D54 PE Hu F
1ml (100 Tests) / €290.00
  Acris Antibodies GmbH

MIC-B antibody

MIC-B Mouse IgG1 B-D55 Azide Free Hu
0.2 mg / €270.00
  Acris Antibodies GmbH

MIC-B antibody

Western Blot analysis of MICB expression in transfected 293T cell line (H00004277-T01) by MICB MaxPab polyclonal antibody.

Lane 1: MICB transfected lysate(37.4 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

MIC-B antibody

Immunoprecipitation of MICB transfected lysate using anti-MICB MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with MICB MaxPab mouse polyclonal antibody (B01) (H00004277-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MIC-B

MIC-B Human in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MIC-B

MIC-B Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

MIC-B

MIC-B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

MIC-B

MIC-B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

MIC-B

MIC-B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

MIC-B

MIC-B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

MICB (Human) IP-WB Antibody Pair

MICB (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

ELISA Kits

Catalog No.    

Human MICB ELISA Kit

Representative Standard Curve  
96 Tests / €450.00
  Cohesion Biosciences Ltd.

Lysates

Catalog No.    

MICB 293T Cell Transient Overexpression Lysate(Denatured)

MICB 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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