MIIP / IIP45 antibody

Principal name

MIIP / IIP45 antibody

Alternative names for MIIP / IIP45 antibody

Invasion-inhibitory protein 45, IGFBP2-binding protein, RP5-1077B9.4, Migration and invasion-inhibitory protein

SwissProt ID

A2A7Y5 (Mouse), Q5JXC2 (Human), Q6AYH0 (Rat)

Gene ID

60672 (MIIP)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of MIIP / IIP45 antibody

MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. Isoform 2 is degraded by the ubiquitin-proteasome pathway.

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MIIP / IIP45 antibody

Western Blot analysis of RP5-1077B9.4 expression in transfected 293T cell line (H00060672-T01) by RP5-1077B9.4 MaxPab polyclonal antibody.

Lane 1: RP5-1077B9.4 transfected lysate(42.68 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

MIIP / IIP45 antibody

Immunohistochemistry-Paraffin: RP5-1077B9.4 Antibody [NBP1-87394] Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MIIP / IIP45

MIIP / IIP45 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MIIP / IIP45

MIIP / IIP45 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

RP5-1077B9.4 293T Cell Transient Overexpression Lysate(Denatured)

RP5-1077B9.4 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

MIIP overexpression lysate

MIIP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

6 Item(s)

per page
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