Mineralocorticoid receptor antibody

Principal name

Mineralocorticoid receptor antibody

Alternative names for Mineralocorticoid receptor antibody

NR3C2, MCR, MLR, MR

SwissProt ID

P08235 (Human), P22199 (Rat), P79404 (Pig), Q8QHI2 (Chick), Q8VII8 (Mouse), Q9BDJ7 (Sheep)

Gene ID

4306 (NR3C2)

Available reactivities

Chk (Chicken), Hu (Human), Rb (Rabbit), Rt (Rat), Ms (Mouse), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of Mineralocorticoid receptor antibody

NR3C2 (nuclear receptor subfamily 3, group C, member 2) also known as MR (mineralocorticoid receptor) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. NR3C2 is a receptor with high affinity for mineralocorticoids. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. MR is expressed in many tissues, such as the kidney, colon, heart, central nervous system (hippocampus), brown adipose tissue and sweat glands. In epithelial tissues, its activation leads to the expression of proteins regulating ionic and water transports (mainly the epithelial sodium channel or ENaC, Na+/K+ pump, serum and glucocorticoid induced kinase or SGK1) resulting in the reabsoprtion of sodium, and as a consequence an increase in extracellular volume, increase in blood pressure, and an excretion of potassium to maintain a normal salt concentration in the body. The receptor is activated by mineralocorticoids such as aldosterone and deoxycorticosterone as well as glucocorticoids, like cortisol. In intact animals, the mineralocorticoid receptor is "protected" from glucocorticoids by co-localization of an enzyme, 11ß-hydroxysteroid dehydrogenase type 2 (11ß-HSD2), that converts cortisol to inactive cortisone. It also responds to some progestins. Spironolactone and eplerenone are mineralocorticoid receptor antagonists. Activation of the mineralocorticoid receptor, upon the binding of its ligand aldosterone, results in its translocation to the cell nucleus, homodimerization and binding to hormone response elements present in the promoter of some genes. This results in the complex recruitment of the transcriptional machinery and the transcription into mRNA of the DNA sequence of the activated genes.

General readings

This product has been used in:Ma K et al. Major conformational changes occur during the transition from an initiation complex to an elongation complex by T7 RNA polymerase. J Biol Chem 277:43206-15 (2002). PubMed PMID: 12186873
Lombes M et al. Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase in the human heart. Circulation 92:175-82 (1995). PubMed PMID: 7600648
Couette B et al. Aldosterone antagonists destabilize the mineralocorticosteroid receptor. Biochem J 282 (Pt 3):697-702 (1992). PubMed PMID: 1313229
Lombes M et al. Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor. Circ Res 71:503-10 (1992). PubMed PMID: 1323429
Lombes M et al. Immunohistochemical localization of renal mineralocorticoid receptor by using an anti-idiotypic antibody that is an internal image of aldosterone. Proc Natl Acad Sci U S A 87:1086-8 (1990). PubMed PMID: 2153968
Lombes M et al. Internal image properties of a monoclonal auto-anti-idiotypic antibody and its binding to aldosterone receptors. J Biol Chem 264:2528-36 (1989). PubMed PMID: 2521629
General / background references:Kenouch S et al. Human skin as target for aldosterone: coexpression of mineralocorticoid receptors and 11 beta-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab 79:1334-41 (1994). PubMed PMID: 7962326

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Mineralocorticoid receptor antibody

WB Suggested Anti-NR3C2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: PANC1 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Mineralocorticoid receptor antibody

WB Suggested Anti-NR3C2 Antibody Titration: 1.25 ug/ml; Positive Control: A172 cell lysate.NR3C2 is supported by BioGPS gene expression data to be expressed in A172 Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Mineralocorticoid receptor antibody

Mineralocorticoid receptor Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Mineralocorticoid receptor antibody

Mineralocorticoid receptor Mouse IgG2a 2B5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Mineralocorticoid receptor antibody

Human HT1080; WB Suggested Anti-NR3C2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: HT1080 cell lysate; NR3C2 antibody - N-terminal region (ARP31008_P050) in Human HT1080 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Mineralocorticoid receptor antibody

Human kidney; NR3C2 antibody - middle region (ARP45599_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Chk, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

Mineralocorticoid receptor antibody

Mineralocorticoid receptor Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

Mineralocorticoid receptor antibody

Mineralocorticoid receptor Mouse IgG2a H3122 Purified Hu, Ms, Rt ELISA, P, WB
0.1 ml / €640.00
  Funakoshi Co., Ltd.

Mineralocorticoid receptor antibody

Mineralocorticoid receptor Mouse IgG1 H10E4C9F Ascites Chk, Hu, Rb, Rt ICC/IF, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Mineralocorticoid receptor antibody

Immunohistochemistry-Paraffin: Mineralocorticoid Receptor Antibody [NBP1-70640] - Human kidney, epithelial cells of renal tubule (indicated with arrows). Rabbit Purified Chk, Hu, Ms, Rt P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Mineralocorticoid receptor

Mineralocorticoid receptor Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Mineralocorticoid receptor

Mineralocorticoid receptor Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

12 Item(s)

per page
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