Mitofusin-1 antibody

Principal name

Mitofusin-1 antibody

Alternative names for Mitofusin-1 antibody

MFN1, Transmembrane GTPase MFN1, Fzo

SwissProt ID

Q811U4 (Mouse), Q8IWA4 (Human), Q8R4Z9 (Rat)

Gene ID

55669 (MFN1), 192647 (Mfn1), 67414

Available reactivities

Hu (Human), Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Mky (Monkey), Ms (Mouse), Prim (Primate), Rb (Rabbit), Rt (Rat), Ze (Zebrafish)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of Mitofusin-1 antibody

Mitochondria are dymic organelles that continuously divide and fuse, and their dymics/distribution is critical for their role in bioenergetics and cell survival. Mitochondrial fusion process is mediated by mitofusin 1 (MFN1) and mitofusin 2 (MFN2) proteins in the outer membrane as well as OPA1 in the inner mitochondrial membrane. MFN1 is an essential transmembrane GTPase critical to mitochondrial fusion; acts independently of the cytoskeleton, and its overexpression induces formation of mitochondrial networks. MFN1 forms homo-/-heteromultimers (with MFN2), and the multimerization has been proposed to be essential for mitochondrion fusion. MFN1 interacts with VAT1 and is ubiquitited by MARCH5. A mutation in the GTPase domain disrupts the mitochondrial fusion activity of MFN1/MFN2 and loss of MFN1/2 leads to mitochondrial dysfunction mediated embryonic lethality in mice. MFN proteins have been reported to regulate mitochondrial membrane potential, while silencing of MFN1/2 resulte in mitochondrial fragmentation and increased apoptotic sensitivity.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Mitofusin-1 antibody

  Mouse Monoclonal Mitofusin Antibody (11E9-1H12)  
Western Blot: MFN1 Antibody (11E9-1H12) - Western blot analysis of MFN1 expression in 1) MEF wild-type and 2) MEF MNF1-null whole cell lysates using anti-MFN1. Mouse IgG 11E9-1H12 Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Mitofusin-1 antibody

  Anti-MFN1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using MFN1 antibody at dilution 1/60, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Mitofusin-1 antibody

  Rabbit Polyclonal Mitofusin 1 Antibody  
Immunohistochemistry: Mitofusin-1 Antibody [TA336806] - IHC staining of Mfn1 in mouse intestine. Rabbit Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Mitofusin-1 antibody

  Rabbit Polyclonal Anti-MFN1 Antibody - middle region  
WB Suggested Anti-MFN1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Mitofusin-1 antibody

  Rabbit Polyclonal Anti-MFN1 Antibody - N-terminal region  
Host: Rabbit; Target Name: MFN1; Sample Tissue: Fetal Muscle lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Mitofusin-1 antibody

  Rabbit Polyclonal Anti-MFN1 Antibody  
Western blot analysis of MFN1 in A431 cell lysate with MFN1 antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Mitofusin-1 antibody

  MFN1 mouse monoclonal antibody, clone OTID11 (formerly D11)  
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-MFN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802148) Mouse IgG1 OTID11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mitofusin-1 antibody

  MFN1 mouse monoclonal antibody, clone OTI4H4 (formerly 4H4)  
Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-MFN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802150) Mouse IgG1 OTI4H4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mitofusin-1 antibody

  MFN1 mouse monoclonal antibody, clone OTIE4 (formerly E4)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MFN1 (RC207184, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MFN1. Mouse IgG1 OTIE4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mitofusin-1 antibody

  MFN1 mouse monoclonal antibody, clone OTIC5 (formerly C5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MFN1 (RC207184, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MFN1. Mouse IgG1 OTIC5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mitofusin-1 antibody

Immunoblot versus crude cardiac mitochondrial preps from WT, Mfn2 KO Mfn1 KO mice and probed with N111/24 TC supe. Samples courtesy of Dr. Suzanne Hoppins, Dr. Laura Lackner and Dr. Jodi Nunnari, UCDavis. Mouse IgG1 N111/24 Supernatant Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Mitofusin-1 antibody

Immunoblot versus crude cardiac mitochondrial preps from WT, Mfn2 KO Mfn1 KO mice and probed with N111/24 TC supe. Samples courtesy of Dr. Suzanne Hoppins, Dr. Laura Lackner and Dr. Jodi Nunnari, UCDavis. Mouse IgG1 N111/24 Purified Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Mitofusin-1 (745-756) antibody

Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bov, Bt, Can, Elephant, Eq, Hu, Mky, Ms, Platypus, Prim, Rb, Rt P
50 µg / €470.00
  Acris Antibodies GmbH

Mitofusin-1 (Center) antibody

MFN1 Antibody (Center) (Cat. #AP52679PU-N) western blot analysis in Jurkat cell line lysates (35µg/lane).This demonstrates the MFN1 antibody detected the MFN1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MFN1 - human gene knockout kit via CRISPR

MFN1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MFN1 - human gene knockout kit via CRISPR

MFN1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MFN1 - human gene knockout kit via CRISPR

MFN1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MFN1 - human gene knockout kit via CRISPR

MFN1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mfn1 - mouse gene knockout kit via CRISPR

Mfn1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mfn1 - mouse gene knockout kit via CRISPR

Mfn1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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