mKi-67 antibody

Principal name

mKi-67 antibody

Alternative names for mKi-67 antibody

mKi67 antigen, Proliferation marker

SwissProt ID

Q61769 (Mouse)

Gene ID

4288 (MKI67)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit, Rat

Available applications

Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Western blot / Immunoblot (WB)

Background of mKi-67 antibody

The nuclear protein Ki-67 was first identified by the monoclonal antibody Ki-67, which was generated by immunizing mice with nuclei of the L428 Hodgkin lymphoma cell line. Ki-67 protein plays an essential role in ribosomal RNA transcription and cell proliferation. Expression of Ki-67 occurs during G1, S, G2, and M phase, while in G0 phase the Ki-67 protein is not detectable. Ki-67 is strongly expressed in proliferating cells and has been reported as a prognostic marker in various tumors. 
Structure: 325 kD protein containing a forkhead-associated domain (FHA) and 13 tandem repeats.
Distribution: Nucleus and chromosomeFunction:Required for cell cycle progression and proliferation.
Interaction: Interacts with KIF15; binds to MKI67IP through FHA domain.

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