MKNK2 antibody

Principal name

MKNK2 antibody

Alternative names for MKNK2 antibody

GPRK7, MNK2, MAP kinase-interacting serine/threonine-protein kinase 2

SwissProt ID

Q5U2N4 (Rat), Q8CDB0 (Mouse), Q9HBH9 (Human)

Gene ID

2872 (MKNK2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of MKNK2 antibody

MAP kinase-interacting kinase 1 (Mnk1) and Mnk2, members of the Ser/Thr protein kinase family, bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2. Erk and p38 phosphorylate MNK1 and Mnk2, which stimulates their in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E). Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. This ubiquitiously expressed protein appears to regulate transcription by phosphorylating eIF-4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94% identical) and human Mnk1 (71% identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta. Mnk2 has also been shown to interact with the C-terminal regions of eIF-4G1 and eIF-4G2.

General readings

Wang,P., (2006) Sci. China, C, Life Sci. 49 (3), 265-273

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MKNK2 antibody

Immunofluorescence of monoclonal antibody to MKNK2 on HeLa cell. [antibody concentration 25 ug/ml] Mouse IgG2a 4F11 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MKNK2 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between MAPK14 and MKNK2 HeLa cells were stained with anti-MAPK14 rabbit purified polyclonal 1:1200 and anti-MKNK2 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG2a 2A10 Purified Hu, Ms, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MKNK2 antibody

Western blot analysis of extracts from HeLa cells, using MNK2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MKNK2 antibody

WB Suggested Anti-MKNK2 Antibody Titration: 1 ug/ml; Positive Control: 721_B cell lysateMKNK2 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

MKNK2 (N-term) antibody

The anti-MKNK2 Pab is used in Western blot to detect MKNK2 in mouse lung tissue lysate. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MKNK2 (C-term) antibody

Western blot analysis of MNK2 (MKNK2) antibody (C-term) in 293 cell line lysates (35ug/lane). MNK2 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MKNK2 antibody

MKNK2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MKNK2 antibody

MKNK2 polyclonal antibody (A02), Lot # 060717JCS1 Western Blot analysis of MKNK2 expression in HeLa ( Cat # L013V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MKNK2 antibody

Western Blot analysis of MKNK2 expression in transfected 293T cell line (H00002872-T01) by MKNK2 MaxPab polyclonal antibody.

Lane 1: MKNK2 transfected lysate(46.70 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

MKNK2 antibody

MKNK2 Rabbit Hu E
0.4 ml / €390.00
  Abnova Taiwan Corp.

MKNK2 antibody

The MKNK2 polyclonal antibody ( Cat # PAB4593 ) is used in Western blot to detect MKNK2 in mouse lung tissue lysate . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

MKNK2 antibody

Human Spleen; MKNK2 antibody - N-terminal region (ARP55352_P050) in Human Spleen cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

MKNK2 antibody

Western Blot: MNK2 Antibody [NBP1-58899] - This Anti-MKNK2 antibody was used in Western Blot of 721_B tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €440.00
  Novus Biologicals Inc.

MKNK2 antibody

Immunohistochemistry-Paraffin: MNK2 Antibody [NBP1-92129] - Immunohistochemical staining of human gall bladder shows moderate cytoplasmic and nuclear positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MKNK2 (transcript variant 2)

MKNK2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MKNK2 (full length, N-term HIS tag, transcript variant 1)

MKNK2 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

MKNK2

MKNK2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MKNK2

MKNK2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

MKNK2

MKNK2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MKNK2

MKNK2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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