MKNK2 antibody

Principal name

MKNK2 antibody

Alternative names for MKNK2 antibody

GPRK7, MNK2, MAP kinase-interacting serine/threonine-protein kinase 2

SwissProt ID

Q5U2N4 (Rat), Q8CDB0 (Mouse), Q9HBH9 (Human)

Gene ID

2872 (MKNK2), 17347 (Mknk2), 299618

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of MKNK2 antibody

MAP kinase-interacting kinase 1 (Mnk1) and Mnk2, members of the Ser/Thr protein kinase family, bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2. Erk and p38 phosphorylate MNK1 and Mnk2, which stimulates their in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E). Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. This ubiquitiously expressed protein appears to regulate transcription by phosphorylating eIF-4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94% identical) and human Mnk1 (71% identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta. Mnk2 has also been shown to interact with the C-terminal regions of eIF-4G1 and eIF-4G2.

General readings

Wang,P., (2006) Sci. China, C, Life Sci. 49 (3), 265-273

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MKNK2 antibody

  Rabbit polyclonal anti-MNK2 antibody  
Western blot analysis of extracts from HeLa cells, using MNK2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MKNK2 antibody

  Rabbit Polyclonal Anti-MKNK2 Antibody  
WB Suggested Anti-MKNK2 Antibody Titration: 1 ug/ml; Positive Control: 721_B cell lysateMKNK2 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

MKNK2 (N-term) antibody

The anti-MKNK2 Pab is used in Western blot to detect MKNK2 in mouse lung tissue lysate. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MKNK2 (C-term) antibody

Western blot analysis of MNK2 (MKNK2) antibody (C-term) in 293 cell line lysates (35ug/lane). MNK2 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MKNK2 - human gene knockout kit via CRISPR

MKNK2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MKNK2 - human gene knockout kit via CRISPR

MKNK2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MKNK2 - human gene knockout kit via CRISPR

MKNK2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MKNK2 - human gene knockout kit via CRISPR

MKNK2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mknk2 - mouse gene knockout kit via CRISPR

Mknk2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mknk2 - mouse gene knockout kit via CRISPR

Mknk2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mknk2 - mouse gene knockout kit via CRISPR

Mknk2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mknk2 - mouse gene knockout kit via CRISPR

Mknk2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MKNK2 (transcript variant 2)

  Recombinant protein of human MAP kinase interacting serine/threonine kinase 2 (MKNK2), transcript variant 2  
MKNK2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MKNK2 (full length, N-term HIS tag, transcript variant 1)

  Recombinant protein of human MAP kinase interacting serine/threonine kinase 2 (MKNK2), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug  
MKNK2 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MKNK2 overexpression lysate

MKNK2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MKNK2 (mGFP-tagged) - Human MAP kinase interacting serine/threonine kinase 2 (MKNK2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, MKNK2 (mGFP-tagged) - Human MAP kinase interacting serine/threonine kinase 2 (MKNK2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, MKNK2 (Myc-DDK tagged) - Human MAP kinase interacting serine/threonine kinase 2 (MKNK2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, MKNK2 (Myc-DDK tagged) - Human MAP kinase interacting serine/threonine kinase 2 (MKNK2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Mknk2 (GFP-tagged) - Mouse MAP kinase-interacting serine/threonine kinase 2 (Mknk2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mknk2 (GFP-tagged) - Mouse MAP kinase-interacting serine/threonine kinase 2 (Mknk2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Mknk2 (Myc-DDK-tagged) - Mouse MAP kinase-interacting serine/threonine kinase 2 (Mknk2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mknk2 (Myc-DDK-tagged) - Mouse MAP kinase-interacting serine/threonine kinase 2 (Mknk2), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Mknk2 (GFP-tagged ORF) - Rat MAP kinase-interacting serine/threonine kinase 2 (Mknk2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mknk2 (GFP-tagged ORF) - Rat MAP kinase-interacting serine/threonine kinase 2 (Mknk2), 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

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