MLH1 antibody

Principal name

MLH1 antibody

Alternative names for MLH1 antibody

DNA mismatch repair protein Mlh1, COCA2

SwissProt ID

P38920 (Yeast), P40692 (Human), P97679 (Rat), Q9JK91 (Mouse)

Gene ID

4292 (MLH1), 4342925 (Os07g0280200), 4286 (MITF)

Available reactivities

Hst (Hamster), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Chk (Chicken), Dros (Drosophila), Por (Porcine), African clawed frog, Mky (Monkey), Bov (Bovine), Eq (Equine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), PLA/Proximity ligation assay (PLA), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of MLH1 antibody

DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a commoncharacteristic of several different types of human cancers, either due to anMMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integralpart of the protein complex responsible for mismatch repair expressed inlymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid andgall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectalcancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.

General readings

Machin et al. J Cutan Pathol 29 (7): 415, 2002

  1. Quick-Filters:
  2. Highly Validated (4)

Items 1 to 20 of 39 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MLH1 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-MLH1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 110C for 10 min, UM800083)(1:200) Mouse IgG1 UMAB191 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

MLH1 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-MLH1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 110C for 10 min, UM800083)(1:200) Mouse IgG1 UMAB191 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

MLH1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MLH1 rabbit polyclonal antibody. (TA590013) Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MLH1 antibody

Immunoperoxidase of monoclonal antibody to MLH1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 1ug/ml] Mouse IgG M1 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MLH1 antibody

Human colon carcinoma stained with anti-MLH1 antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

MLH1 antibody

Human colon carcinoma stained with anti-MLH1 antibody Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

MLH1 antibody

Human colon carcinoma stained with anti-MLH1 antibody Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

MLH1 antibody

Western blot analysis of extracts from K562 cells, using MLH1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MLH1 antibody

Western blot analysis of extracts of various cell lines, using MLH1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MLH1 antibody

WB Suggested Anti-MLH1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MLH1 antibody

Western blot detection of MLH1 in Hela,293T and Jurkat cell lysates using MLH1 mouse mAb (1:500 diluted).Predicted band size:85KDa.Observed band size:85KDa. Mouse IgG2b 2B3-H6-C11 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MLH1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MLH1 mouse monoclonal antibody. (TA805066; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG1 OTI1C1 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MLH1 antibody

Immunohistochemical analysis of paraffin-embedded human rectum cancer (left) and ovarian cancer (right) tissues, showing nuclear localization with DAB staining using MLH1 antibody Cat.-No AM06257SU-N Mouse IgG1 4C9C7 Ascites Hu, Mky ICC/IF, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

MLH1 antibody

Formalin-Fixed, Paraffin-Embedded Human colon carcinoma stained with MLH1 antibody Cat.-No. AM10114SU-N using peroxidase conjugate and DAB chromogen. Note the nuclear staining of tumor cells. Mouse IgG1 G168-728 Supernatant Hst, Hu, Ms, Rt P
1 ml / €440.00
  Acris Antibodies GmbH

MLH1 antibody

Human Small Intestine (formalin-fixed, paraffin-embedded) stained with MLH1 antibody AM20522SU-N followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 n.a Ascites Hu, Mky E, ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

MLH1 antibody

Western blot (WB) analysis of MLH1 antibody (Cat.-No.: AP20490PU-N) in extracts from K562 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MLH1 (Center) antibody

Western blot analysis in K562 cell line lysates (35ug/lane) using MLH1 antibody Cat.-No. AP52704PU-N. This demonstrates the MLH1 antibody detected the MLH1 protein (arrow). Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MLH1 antibody

Formalin fixed paraffin embedded human tonsil stained with MLH-1 antibody DM430/DM430-05 Mouse IgG1 G168-15 Supernatant Hst, Hu, Ms, Rt C, P
1 ml / €610.00
  Acris Antibodies GmbH

MLH1 antibody

Formalin fixed paraffin embedded human tonsil stained with MLH-1 antibody DM430/DM430-05 Mouse IgG1 G168-15 Supernatant Hst, Hu, Rt P
0.5 ml / €400.00
  Acris Antibodies GmbH

MLH1 antibody

SP2066P staining MLH1 in human gastric cancer. Formalin fixed, paraffin processed tissue. Rabbit Aff - Purified Hu C, IP, WB
50 µg / €320.00
  Acris Antibodies GmbH

Items 1 to 20 of 39 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn