MLL / HRX antibody

Principal name

MLL / HRX antibody

Alternative names for MLL / HRX antibody

ALL1, CXXC7,HTRX, KMT2A, TRX1, ALL-1, Zinc finger protein HRX, Histone-lysine N-methyltransferase HRX, Trithorax-like protein, Lysine N-methyltransferase 2A, CXXC-type zinc finger protein 7

SwissProt ID

P55200 (Mouse), Q03164 (Human)

Gene ID

4297 (MLL)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of MLL / HRX antibody

The MLL gene encodes a D-binding protein that methylates histone H3 (see MIM 601128) lys4 (H3K4) and positively regulates expression of target genes, including multiple HOX genes (see MIM 142980). MLL is a frequent target for recurrent translocations in acute leukemias that may be characterized as acute myeloid leukemia (AML; MIM 601626), acute lymphoblastic leukemia (ALL), or mixed lineage (biphenotypic) leukemia (MLL). Leukemias with translocations involving MLL possess unique clinical and biologic characteristics and are often associated with poor prognosis. MLL rearrangements are found in more than 70% of infant leukemias, whether the immunophenotype is more consistent with ALL or AML6, but are less frequent in leukemias from older children. MLL translocations are also found in approximately 10% of AMLs in adults, as well as in therapy-related leukemias, most often characterized as AML, that develop in patients previously treated with topoisomerase II inhibitors for other maligncies. More than 50 different MLL fusion partners have been identified. Leukemogenic MLL translocations encode MLL fusion proteins that have lost H3K4 methyltransferase activity. A key feature of MLL fusion proteins is their ability to efficiently transform hematopoietic cells into leukemia stem cells (Krivtsov and Armstrong, 2007 [PubMed 17957188]).[supplied by OMIM]

General readings

1. Armstrong, S. A., Staunton, J. E., Silverman, L. B., Pieters, R., den Boer, M. L., Minden, M. D.,
Sallan, S. E., Lander, E. S., Golub, T. R., Korsmeyer, S. J. MLL translocations specify a distinct
gene expression profile that distinguishes a unique leukemia. Nature Genet. 30: 41-47, 2002.
2. Bruch, J., Wilda, M., Teigler-Schlegel, A., Harbott, J., Borkhardt, A., Metzler, M. Occurrence of
an MLL/LAF4 fusion gene caused by the insertion ins(11;2)(q23;q11.2q11.2) in an infant with acute
lymphoblastic leukemia. (Letter) Genes Chromosomes Cancer 37: 106-109, 2003.
3. Caligiuri, M. A., Strout, M. P., Oberkircher, A. R., Yu, F., de la Chapelle, A., Bloomfield, C. D. The
partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11
is restricted to one chromosome. Proc. Nat. Acad. Sci. 94: 3899-3902, 1997.

5 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MLL / HRX antibody

  MLL Rabbit Polyclonal (aa3830-3845) Antibody  
MLL / HRX Rabbit Purified Hu E, P
50 µg / €400.00
  OriGene Technologies, Inc.

MLL / HRX antibody

  Rabbit Polyclonal KMT2A/MLL Antibody  
Immunohistochemical staining of human colon shows moderate cytoplasmic and nuclear positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only. Rabbit IgG Purified Hu E, P
0.1 mg / €409.00
  OriGene Technologies, Inc.

MLL / HRX (3751-3968) antibody

Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and esophagus cancer (right), showing nuclear weak staining with DAB staining using anti-MLL Monoclonal Antibody. Mouse IgG1 10F8D7 Ascites Hu E, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

MLL / HRX (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KMT2A (Myc-DDK tagged) - Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (MLL), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, KMT2A (Myc-DDK tagged) - Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (MLL), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,349.00
  OriGene Technologies, Inc.

5 Item(s)

per page
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