MLL5 antibody

Principal name

MLL5 antibody

Alternative names for MLL5 antibody

KMT2E, Histone-lysine N-methyltransferase MLL5, Myeloid/lymphoid or mixed-lineage leukemia protein 5, Lysine N-methyltransferase 2E

SwissProt ID

Q3UG20 (Mouse), Q8IZD2 (Human)

Gene ID

55904 (MLL5), 69188 (Mll5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Frozen Sections (C)

Background of MLL5 antibody

MLL5 is a divergent member of the Drosophila Trithorax related SET and PHD domain containing chromatin regulators that are involved in the regulation of transcriptional "memory" during differentiation. Human MLL5 is located on chromosome 7q22, that is frequently deleted in myeloid leukemias. Inactivation of the Mll5 gene in mice results in a reduction in the average representation of hematopoietic stem cells, and in functional impairment of long term hematopoietic repopulation potential under competitive conditions. Overexpression of the protein also inhibits cell cycle progression.This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized.

General readings

Heuser M. et al. Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation. Blood. 2009 Feb 12;113(7):1432-43. Epub 2008 Oct 14.

7 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MLL5 antibody

Anti-MLL5 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Rabbit Purified Hu E, P
50 µg / €345.00
  OriGene Technologies, Inc.

MLL5 antibody

MLL5 Rabbit Serum Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

MLL5 antibody

Western Blot analysis of MLL5 expression in transfected 293T cell line (H00055904-T02) by MLL5 MaxPab polyclonal antibody.

Lane 1: MLL5 transfected lysate(66.99 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

MLL5 antibody

Immunoprecipitation of MLL5 transfected lysate using anti-MLL5 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with MLL5 MaxPab mouse polyclonal antibody (B01) (H00055904-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

MLL5 antibody

MLL5 Rabbit Purified Hu E, P
50 µg / €480.00
  Novus Biologicals Inc.

MLL5 antibody

MLL5 Rabbit Serum Hu, Ms, Rt P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

MLL5 293T Cell Transient Overexpression Lysate(Denatured)

MLL5 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

7 Item(s)

per page
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