MLLT10 / AF10 antibody

Principal name

MLLT10 / AF10 antibody

Alternative names for MLLT10 / AF10 antibody

myeloid/lymphoid or mixed-lineage leukemia translocated to 10

SwissProt ID

O54826 (Mouse), P55197 (Human)

Gene ID

8028 (MLLT10), 17354 (Mllt10)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MLLT10 / AF10 antibody

Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t(10;11)(p12;q23) translocations. In an analysis of two leukemia patients, the in t(10;11)(p12;q23) translocation fuses MLL1, a SET domain containg histone methyltransferase, to the MLLT10 gene. The MLLT10 gene encodes a predicted 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain. The MLLT10 gene is one of the few MLL partner genes to be independently rearranged with a third gene in leukemia, the CALM gene in the t(10;11)(p12;q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 consistently retain the leucine zipper motif of MLLT10. The leucine zipper interacts with GAS41, a protein previously identified as the product of an amplified gene in a glioblastoma. GAS41 interacts with integrase interactor-1 (INI1), a component of the SWI/SNF complex, which acts to remodel chromatin and to modulate transcription. Retention of the leucine zipper in the MLL and CALM fusions suggested that a key feature of these chimeric proteins may be their ability to interfere in normal gene regulation through interaction with the adenosine triphosphate-dependent chromatin remodeling complexes.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MLLT10 / AF10 antibody

(1ug/ml) staining of Rat Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MLLT10 / AF10 antibody

Western blot analysis of extracts from COLO205 cells and Jurkat cells, using AF10 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MLLT10 / AF10 antibody

Western blot analysis of MLLT10 (Cat. #TA324662) in K562 cell line lysates (35ug/lane). MLLT10 (arrow) was detected using the purified Pab.(2ug/ml) Rabbit IgG Purified Hu ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

MLLT10 / AF10 antibody

MLLT10 / AF10 Rabbit IgG Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MLLT10 / AF10 (1013-1027) antibody

Figure 1. Staining MLLT10 in Testis by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

MLLT10 / AF10 (C-term) antibody

Formalin-fixed and paraffin-embedded human testis tissue reacted with MLLT10 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MLLT10 / AF10 antibody

Western blot (WB) analysis of AF-10 antibody (Cat.-No.: AP20389PU-N) at 1/500 dilution.Lane 1: Hela cell lysate.v  Lane 2: Mouse testis tissue lysate. Lane 3: Rat testis tissue lysate. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MLLT10 / AF10 antibody

MLLT10 / AF10 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MLLT10 / AF10 antibody

MLLT10 / AF10 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

MLLT10 / AF10 antibody

MLLT10 monoclonal antibody (M01), clone 6H8 Western Blot analysis of MLLT10 expression in Hela NE ( Cat # L013V3 ). Mouse IgG1 6H8 Purified Hu, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MLLT10 / AF10 antibody

MLLT10 monoclonal antibody (M02), clone 2B9 Western Blot analysis of MLLT10 expression in Hela NE ( Cat # L013V3 ). Mouse IgG1 2B9 Purified Hu, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MLLT10 / AF10 antibody

MLLT10 monoclonal antibody (M03), clone 6H7 Western Blot analysis of MLLT10 expression in Hela NE ( Cat # L013V3 ). Mouse IgG1 6H7 Purified Hu, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MLLT10 / AF10 antibody

Formalin-fixed and paraffin-embedded human testis tissue reacted with MLLT10 polyclonal antibody ( Cat # PAB4767 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

MLLT10 / AF10 antibody

Western blot analysis of extracts from COLO205/Jurkat cells, using AF10 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

MLLT10 / AF10 antibody

Western blot analysis of extracts from COLO205/Jurkat cells, using AF10 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

MLLT10 / AF10 antibody

A selection of western blots using AF10 9A5/2 Mouse IgG2b HAF10 9A5/2 Purified Hu E, F, IP, WB
0.1 mg / €320.00
  Novus Biologicals Inc.

MLLT10 / AF10 antibody

Western Blot: AF-10 Antibody [NBP1-19544] - extracts from COLO205 cells. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

MLLT10 / AF10 antibody

MLLT10 / AF10 Goat Aff - Purified Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

MLLT10 / AF10 antibody

Immunohistochemistry-Paraffin: AF10 Antibody [NBP1-90222] - Immunohistochemical staining of human testis shows strong nuclear positivity in cells of seminiferus ducts. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MLLT10 / AF10

MLLT10 / AF10 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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