MLLT11 / AF1Q antibody

Principal name

MLLT11 / AF1Q antibody

Alternative names for MLLT11 / AF1Q antibody

Protein AF1q

SwissProt ID

P97783 (Mouse), Q0VCT1 (Bovin), Q13015 (Human), Q5M971 (Rat)

Gene ID

10962 (MLLT11)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of MLLT11 / AF1Q antibody

The gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23. Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and 5% of patients with acute myeloid leukemia (AML). Most patients affected are less than 1 year of age. MLLT11, also known as mixed-lineage leukemia translocated to 11 or AF1q, is a 90 amino acid MLL fusion partner. Based on the expression patterns of MLLT11, it is thought that MLLT11 plays a role in leukemogenesis and, specifically, the progression of acute monocytic leukemia (AML). Also, expressed in embryonic brain cortex, MLLT11 is upregulated during neuronal differentiation and is thought to play a role in the development of the central nervous system. Finally, MLLT11 has been shown to be differentially expressed in highly metastatic cells, in comparison with non-metastatic parent cells. Such findings suggest a role of MLLT11 in tumorigenesis.

General readings

Chang X Z., et al. (2008) Breast cancer Res Treat. 111: 65-78.Tse W., et al. (1995) Blood. 85: 650-656.

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MLLT11 / AF1Q antibody

Detection limit for recombinant GST tagged MLLT11 is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 2A9-1B7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MLLT11 / AF1Q antibody

Immunohistochemistry-Paraffin: MLLT11 Antibody (CHCR115) [NBP1-95642] human thymus tissue using anti-MLLT11 / AF1Q. Rabbit CHCR115 Purified Hu ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MLLT11 / AF1Q (1-90, His-tag)

MLLT11 / AF1Q Human Purified > 80 % by SDS - PAGE E. coli
0.5 mg / €940.00
  Acris Antibodies GmbH

MLLT11 / AF1Q (1-90, His-tag)

MLLT11 / AF1Q Human Purified > 80 % by SDS - PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

MLLT11 / AF1Q

MLLT11 / AF1Q Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MLLT11 / AF1Q

MLLT11 / AF1Q Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

6 Item(s)

per page
  • LinkedIn