MLLT3 / AF9 antibody

Principal name

MLLT3 / AF9 antibody

Alternative names for MLLT3 / AF9 antibody

YEATS3, Protein AF-9, Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein, ALL1 fused gene from chromosome 9 protein, YEATS domain-containing protein 3

SwissProt ID

A2AM29 (Mouse), P42568 (Human)

Gene ID

4300 (MLLT3)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Ze (Zebrafish), African clawed frog, Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of MLLT3 / AF9 antibody

The human AF9 gene is one of the most common fusion partner genes with the ALL1 gene at 11q23 (also called MLL), resulting in the t(9;11)(p22;q23). The AF9 gene is more than 100 kb, and 2 patient breakpoint cluster regions (BCRs) have been identified; BCR1 is within intron 4, previously called site A, whereas BCR2 or site B spans introns 7 and 8. Several different structural elements have been identified in AF9, including a colocalizing in vivo DNA topo II cleavage site and an in vitro DNase I hypersensitive (DNase 1 HS) site in intron 7 in BCR2. Reversibility experiments demonstrated a religation of the topo II cleavage sites. In addition, 2 scaffold associated regions (SARs) are located centromeric to the topo II and DNase I HS cleavage sites and border breakpoint regions in 2 leukemic cells lines: SAR1 is located in intron 4, whereas SAR2 encompasses parts of exons 5-7. The patient breakpoint regions of AF9 share the same structural elements as the MLL BCR. A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.

General readings

Wei,J., (2008) Cancer Cell 13 (6), 483-495

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MLLT3 / AF9 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MLLT3 / AF9 antibody

  Rabbit Polyclonal Anti-MLLT3 Antibody  
WB Suggested Anti-MLLT3 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

MLLT3 / AF9 antibody

  MLLT3 / AF9 Rabbit Polyclonal (aa486-502) Antibody  
Anti-MLLT3 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Rabbit Purified Hu E, P
50 µg / €400.00
  OriGene Technologies, Inc.

MLLT3 / AF9 antibody

  Rabbit Polyclonal Anti-MLLT3 Antibody  
Host: Rabbit; Target Name: MLLT3; Sample Tissue: 721_B cell lysate; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

MLLT3 / AF9 antibody

The anti-MLLT3 Pab is used in Western blot to detect MLLT3 in mouse cerebellum tissue lysate Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MLLT3 / AF9 (N-term) antibody

Western blot analysis of MLLT3 / AF9 Antibody (N-term) Cat.-No AP13159PU-N in HL60 tissue lysate Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MLLT3 - human gene knockout kit via CRISPR

MLLT3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MLLT3 - human gene knockout kit via CRISPR

MLLT3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MLLT3 / AF9

  Recombinant protein of human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3)  
MLLT3 / AF9 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MLLT3 overexpression lysate

MLLT3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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