MLN antibody

Principal name

MLN antibody

Alternative names for MLN antibody

Promotilin, Motilin, MAP, Motilin-associated peptide

SwissProt ID

O18845 (Sheep), O62820 (Bovin), P01307 (Pig), P12872 (Human), Q9PRP6 (Chick)

Gene ID

397466 (MLN), 4295

Available reactivities

Fe (Feline), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Radioimmunoassay (R), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of MLN antibody

Transport of nutrients through the digestive system is highly dependent on gastrointestinal (GI) motility. GI motility disorders include gastroesophageal reflux disease, gastroparesis (diabetic and post surgical), irritable bowel syndrome, and constipation.
Motilin, a 22-amino acid peptide hormone that is secreted by enterochromaffin cells of the small intestine, influences gastric motility by inducing interdigestive (phase III) antrum and duodenal contractions. Most recently, an orphan GPCR related to growth hormone secretagogues receptor (GHS-R) has been isolated and characterized from human stomach as the motilin receptor (MTLR or GPR38; 52% identity with GHS-R). The structurally unrelated macrolide antibiotic erythromycin is known to have Motilin-like side effects, including vomiting, nausea, diarrhea, and abdominal muscular discomfort. MTLR is expressed in enteric neurons of the human duodenum and colon. Interestingly, the macrolide antibiotic erythromycin also binds to MTLR, providing a molecular basis for its effects on the Human GI tract.
Motilin gene (human chromosome 6p21.2) consists of 5 exons spanning approximately 9 kb of genomic DNA. Exon 1 encodes the 5-prime untranslated portion of the motilin mRNA. Exons 2 and 3 encode the signal peptide and the 22-amino acid motilin peptide. The 22-aa mature motilin peptide is highly conserved across species. The motilin prohomrone consists of 115 amino acids and includes a 25-residue N-terminal signal peptide followed by the 22-amino-acid motilin sequence and a long, 68-residue Motilin-related C-terminal peptide. Proteolytic processing of promotilin to motilin occurs at a very unusual and rare "Lys-Lys" sequence. High-affinity binding sites for motilin have been detected in the GI tract of humans and other species and in the central nervous system of rabbits.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MLN antibody

WB Suggested Anti-MLN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: HT1080 cell lysate Rabbit IgG Purified Hu, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

MLN antibody

MLN Rabbit Serum Fe, Hu, Ms, Por, Rt C, P, R
0.25 ml / €320.00
  Acris Antibodies GmbH

MLN antibody

MLN Mouse IgG2a 4E12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MLN antibody

Human HT1080; WB Suggested Anti-MLN Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HT1080 cell lysate; MLN antibody - middle region (ARP44916_P050) in Human HT1080 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

MLN antibody

Western Blot: motilin Antibody [NBP1-59344] - This Anti-MLN antibody was used in Western Blot of HT1080     tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MLN (transcript variant 1)

MLN Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MLN (transcript variant 2)

MLN Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

MLN

MLN Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

MLN

MLN Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MLN overexpression lysate

MLN overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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