MMP-12 antibody

Principal name

MMP-12 antibody

Alternative names for MMP-12 antibody

Macrophage metalloelastase, HME, ME, Matrix metalloproteinase-12, MMP12, Macrophage elastase

SwissProt ID

P34960 (Mouse), P39900 (Human), P79227 (Rabit), Q63341 (Rat)

Gene ID

4321 (MMP12), 17381 (Mmp12), 117033

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Can (Canine), Bov (Bovine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), ELISA (capture) (E(capture)), ELISA capture and detection (E(caption)/E(detection)), Flow Cytometry (F)

Background of MMP-12 antibody

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis, metastasis, and atherosclerosis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 is able to degrade elastin, entactin, laminin 1, fibronectin, type IV collagen as well as insulin B-chain and casein. MMP12 is often confused with the Serine proteinase, Leukocyte elastase (EC 3.4.21.37) because of similar nomenclature. MMP12 is structurally similar to the classical MMPs (MMP1, MMP3); it contains a propeptide with autoinhibitory cysteine switch site, a well-conserved zinc site, hinge region and hemopexin domain. MMP12 lacks a transmembrane domain and furin cleavage site. The zymogen for MMP-12 is about 54 kD, and is quickly activated to the 45 kD form; and this breaks down to cascade of active forms, ending with the common 22 kD form. Stimulated macrophages produce MMP12; it has also been found in osteosarcoma cells, synovial fibroblasts and lung fibroblasts. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-12 antibody

  Goat Anti-MMP12 Antibody  
(0.5ug/ml) staining of Human Breast Cancer lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-12 antibody

  Rabbit polyclonal MMP12 (Cleaved-Glu106) antibody  
Western blot analysis of extracts from NIH-3T3 cells, treated with etoposide (25uM, 1hour), using MMP12 (Cleaved-Glu106) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-12 antibody

  Rabbit Polyclonal Anti-MMP12 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (MMP12 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-12 Control Peptide

MMP-12 Purified
50 µg / €190.00
  Acris Antibodies GmbH

MMP-12 antibody

Western blot analysis of MMP-12 expression in Mouse small intestine tissue lysate. Rabbit Aff - Purified Ms ICC/IF, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

MMP-12 (C-term) antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with MMP12 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MMP-12 antibody

Immunohistochemistry (IHC) analyzes of MMP-12 antibody (Cat.-No.: AP20790PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu P
0.1 mg / €350.00
  Acris Antibodies GmbH

MMP-12 (cleaved) antibody

Western blot analysis of extracts from NIH-3T3 cells, treated with etoposide 25uM 1h, using MMP12 (Cleaved-Glu106) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

MMP-12 (cleaved) antibody

Western blot analysis of extracts from NIH-3T3 cells, treated with etoposide 25uM 1h, using MMP12 (Cleaved-Glu106) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

MMP-12 antibody

Human lung tissue sections Mouse IgG1 603E6.22 Biotin Hu C
50 µg / €360.00
  Dendritics SAS

MMP-12 antibody

Human lung tissue sections Mouse IgG1 603E6.22 Biotin Hu C
0.1 mg / €480.00
  Dendritics SAS

MMP-12 antibody

Human lung tissue sections Mouse IgG1 603E6.22 HRP Hu C
50 µg / €360.00
  Dendritics SAS

MMP-12 antibody

Human lung tissue sections Mouse IgG1 603E6.22 HRP Hu C
0.1 mg / €480.00
  Dendritics SAS

MMP-12 antibody

Human lung tissue sections Mouse IgG1 603E6.22 Purified Hu C, E, IP
50 µg / €330.00
  Dendritics SAS

MMP-12 antibody

Human lung tissue sections Mouse IgG1 603E6.22 Purified Hu C, E, IP
0.1 mg / €440.00
  Dendritics SAS

MMP-12 antibody

MMP-12 Mouse IgG1 706F9.01 Biotin Hu C, E(detection), WB
50 µg / €360.00
  Dendritics SAS

MMP-12 antibody

MMP-12 Mouse IgG1 706F9.01 Biotin Hu C, E(detection), WB
0.1 mg / €480.00
  Dendritics SAS

MMP-12 antibody

IHC staining of human tonsil frozen section with clone 706F9 (DX0281) Mouse IgG1 706F9.01 HRP Hu C, E(detection)
50 µg / €360.00
  Dendritics SAS

MMP-12 antibody

IHC staining of human tonsil frozen section with clone 706F9 (DX0281) Mouse IgG1 706F9.01 HRP Hu C, E(detection)
0.1 mg / €480.00
  Dendritics SAS

MMP-12 antibody

IHC staining of human tonsil frozen section with clone 706F9 (DX0281) Mouse IgG1 706F9.01 Purified Hu C, E(detection), IP, WB
50 µg / €330.00
  Dendritics SAS

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