MMP-13 antibody

Principal name

MMP-13 antibody

Alternative names for MMP-13 antibody

Collagenase 3, MMP13, Matrix metalloproteinase-13

SwissProt ID

O62806 (Rabit), O77656 (Bovin), P23097 (Rat), P33435 (Mouse), P45452 (Human)

Gene ID

4322 (MMP13), 171052 (Mmp13), 4243223 (IPR001095)

Available reactivities

Bov (Bovine), Eq (Equine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Marmoset, Mky (Monkey), Gorilla, Can (Canine), Por (Porcine), Sh (Sheep), Bear, Ze (Zebrafish), Chk (Chicken), African clawed frog, Av (Birds), Hst (Hamster), Op (Opossum)

Available hosts

Rabbit, Mouse, Sheep

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of MMP-13 antibody

Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the skeleton during embryonic development and is highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. Findings demonstrate a unique role of Mmp13 in skeletal development (1). In arthritis, the destruction of fibrillar (type II) collagen is one of the hallmarks, with MMP-1 and MMP-13 being identified as key players in arthritic cartilage. MMP-13, furthermore, has been found in highly metastatic tumors. In contrast to many human MMPs, the MMP-13 distribution pattern is restrictive in normal tissues and selective in pathological conditions. MMP-13 demonstrates versatility in its substrate utilization. In addition to being highly active on type II collagen, MMP-13 cleaves other substrates, mostly macromolecules of the extracellular matrix, but also molecules such as connective tissue (CTGF) and fibrinogen. MMP-13 is controlled at multiple levels: i.e., the expression/synthesis, activation, and inhibition of the active enzyme (3).

General readings

General / background references:Pei D & Yi J A high-level mammalian expression system based on the Madin-Darby canine kidney cell line. Protein Expr Purif 13:277-81 (1998). PubMed PMID: 9675073
Pendas AM et al. Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13). Genomics 40:222-33 (1997). PubMed PMID: 9119388

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-13 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506688) Mouse IgG1 OTI3H3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506689) Mouse IgG2a OTI1G5 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506693) Mouse IgG2a OTI3A7 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506723) Mouse IgG2a OTI3G1 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506803) Mouse IgG2a OTI2A6 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506806) Mouse IgG2a OTI2D8 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Predicted band size: 54kDa. Positive control: Hela cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate:40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-13 antibody

Western blot analysis of extracts of various cell lines, using MMP13 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-13 (N-term) antibody

Anti-MMP13 antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Gorilla, Hu, Marmoset, Mky P
50 µg / €379.00
  OriGene Technologies, Inc.

MMP-13 (internal region) antibody

Anti-MMP13 antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Av, Bear, Bov, Can, Elephant, Eq, Gorilla, Hst, Hu, Marmoset, Mky, Ms, Op, Por, Rb, Rt, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

MMP-13 antibody

Anti-MMP13 antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

MMP-13 (C-term) antibody

Anti-MMP13 antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Bear, Bov, Can, Elephant, Eq, Hu, Mky, Ms, Por, Rb, Rt, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

MMP-13 antibody

Anti-MMP13 mouse monoclonal antibody (TA506692) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MMP13(RC224156). Mouse IgG1 OTI1F1 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506697) Mouse IgG2a OTI4B3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Anti-MMP13 mouse monoclonal antibody (TA506699) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MMP13(RC224156). Mouse IgG1 OTIF4 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506719) Mouse IgG2a OTI2D11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-MMP13 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506721) Mouse IgG2a OTI3F5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

Anti-MMP13 mouse monoclonal antibody (TA506804) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MMP13(RC224156). Mouse IgG1 OTI4B7 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-13 antibody

MMP-13 Mouse IgG1 181-15A12 Purified Hu C, E, P, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

MMP-13 antibody

Western Blot analysis of MMP13 expression with Jurkat Cell Lysate. Rabbit Aff - Purified Bov, Eq, Hu, Ms, Rb, Rt IP, P, WB
0.1 mg / €410.00
  Acris Antibodies GmbH

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