MMP-14 / MT1-MMP antibody

Principal name

MMP-14 / MT1-MMP antibody

Alternative names for MMP-14 / MT1-MMP antibody

Matrix metalloproteinase-14, MMP14, MMP-X1, Membrane-type-1 matrix metalloproteinase,

SwissProt ID

P50281 (Human), P53690 (Mouse), Q10739 (Rat), Q9GLE4 (Bovin), Q9XT90 (Pig)

Gene ID

4323 (MMP14)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Rb (Rabbit), Bov (Bovine), Can (Canine), Por (Porcine), Chimp (Chimpanzee), Eq (Equine), Macaque

Available hosts

Mouse, Rabbit, Chicken, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunoprecipitation (IP)

Background of MMP-14 / MT1-MMP antibody

The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane-type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.MMP14 may be an activator of pro gelatinase A and is expressed in fibroblast cells during both wound healing and human cancer progression. MMP14 is expressed in very low levels and may require stimulation with concanavolin A or the phorbol ester TPA to stimulate production of MMP14. Matrix metalloproteinase-14 precursor is endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. [Catalytic activity] Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain. Highly expressed in placenta, kidney, heart, lung, embryonic skeletal and periskeletal tissues. Belongs to the peptidase M10A family.

General readings

1. Janssens E  et al. Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development. PLoS One 8:e52915 (2013). WB, IHC-P ; Zebrafish .PubMed: 23326364
2. Zamilpa R  et al. CC chemokine receptor 5 deletion impairs macrophage activation and induces adverse remodeling following myocardial infarction. Am J Physiol Heart Circ Physiol300:H1418-26 (2011). WB ; Mouse .PubMed: 21297029
3. Little CB  et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum 60:3723-33 (2009). IHC-P ; Mouse .PubMed: 19950295

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-14 / MT1-MMP antibody

Staining of Human gastric fundus with MMP-14 Antibody Cat.-No AF8410 (Clone 113-5B7) at 2 µg/ml. 
Antibody detects citoplasmatic membranous expression of MMP-14  in stromal cells. 10x Mouse IgG3 113-5B7 Purified Hu, Ms, Rb, Rt C, P, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP (160-173) antibody

Human Lung, Respiratory Epithelium (formalin-fixed, paraffin-embedded) stained with MMP14 antibody AP22706PU-N at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu P
0.25 ml / €470.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP antibody

Human placenta stained
with anti-MMP-14 antibody Rabbit Purified Hu P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP antibody

Human placenta stained
with anti-MMP-14 antibody Rabbit Purified Hu P, WB
1 ml / €440.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP antibody

Human placenta stained
with anti-MMP-14 antibody Rabbit Purified Hu P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP antibody

Staining of A549 lysate using MMP-14 Antibody Cat.-No AP32815PU-N at 1 µg/ml  (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP antibody

Western blot analysis of extracts from NIH/3T3 cells, using MMP-14 antibody (#TA312180).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-14 / MT1-MMP antibody

Western blot analysis of extracts from 293 cells, treated with etoposide (25uM, 1hour), using MMP14 (Cleaved-Tyr112) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-14 / MT1-MMP antibody

Western blot analysis of extracts of various cell lines, using MMP14 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-14 / MT1-MMP antibody

Western blot analysis on NIH-3T3 cell lysate using MMP14 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-14 / MT1-MMP antibody

MMP-14 / MT1-MMP Mouse IgG1 114-1F2 Purified Hu WB
0.1 mg / €300.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP antibody

Mouse anti-MT1-MMP (Catalog Number AF8610) Staining of breast carcinoma. Mouse IgG1 114-6G6 Purified Hu C, E, P, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP antibody

Immunohistochemistry (IHC) analyzes of MMP-14 antibody (Cat.-No.: AP06227PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP (C-term) antibody

MMP14 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt C, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

MMP-14 / MT1-MMP antibody

Western Blot analysis of MMP14 expression in transfected 293T cell line (H00004323-T02) by MMP14 MaxPab polyclonal antibody.

Lane 1: MMP14 transfected lysate(65.90 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

MMP-14 / MT1-MMP antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with MMP14 polyclonal antibody ( Cat # PAB4782 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

MMP-14 / MT1-MMP antibody

Immunohistochemical staining of MMP14 on formalin fixed, paraffin embedded human placenta with MMP14 polyclonal antibody. Rabbit Hu P, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

MMP-14 / MT1-MMP antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MMP-14 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

MMP-14 / MT1-MMP antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MMP-14 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

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