MMP-15 antibody

Principal name

MMP-15 antibody

Alternative names for MMP-15 antibody

MMP15, Matrix metalloproteinase-15, Membrane-type matrix metalloproteinase 2, MT-MMP 2, MTMMP2, Membrane-type-2 matrix metalloproteinase, MT2-MMP, MT2MMP, SMCP-2

SwissProt ID

O54732 (Mouse), P51511 (Human)

Gene ID

17388 (Mmp15), 4324 (MMP15)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of MMP-15 antibody

The mammalian matrix metalloproteinases (MMPs) degrade extracellular matrix in physiological and pathological processes. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT MMPs exist as integral membrane proteins.
MMP15, first described as MTMMP2, is a metalloproteinase with a type I transmembrane domain. Initially reported in lung tissue, MMP15 message was also seen in testis, intestines, colon, heart, liver, kidney, pancreas and muscle. Western blots showed bands at 72 kD, 48 kD and 44 kD. Subsequent publications have focused on message, and found MMP15 in a wide range of tumor cell lines, as well as the synovial membrane from patients with rheumatoid arthritis. MMP15 is usually found in much lower levels than the more ubiquitous MMP14 (MT1MMP). MMP15 may be shed into the culture media when activated, but it is unclear if the shed form is proteolytically active. Cell lysates are the best source for Western blotting of MMP15.

General readings

General / background references:Takino T et al. Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. J Biol Chem 270:23013-20 (1995). PubMed PMID: 7559440
Sato H et al. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 370:61-5 (1994). PubMed PMID: 8015608

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-15 antibody

Staining of FFPE Mouse liver HCC (20x and 40x) with MMP15 Antibody Cat.-No AF881 (Clone 162-22G5) at 2 µg/ml. Antibody positive in the cytoplasm of some macrophages and Kuppfer cells of hepatocellular carcinoma (HCC). Mouse IgG1 162-22G5 Purified Ms C, P, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

MMP-15 antibody

Human placenta stained with Anti-MMP-15 antibody Rabbit Purified Hu, Ms P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

MMP-15 antibody

Human placenta stained with Anti-MMP-15 antibody Rabbit Purified Hu, Ms P, WB
1 ml / €440.00
  Acris Antibodies GmbH

MMP-15 antibody

Human placenta stained with Anti-MMP-15 antibody Rabbit Purified Hu, Ms P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

MMP-15 antibody

Western blot analysis of extracts from MDA-MB-435 cells, using MMP-15 antibody (#TA314206).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-15 antibody

Western blot analysis of extracts from COS-7 cells, treated with etoposide (25uM, 1hour), using MMP15 (Cleaved-Tyr132) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-15 antibody

Predicted band size: 76 kDa . Positive control: Mouse stomach, heart and liver tissue, HT-29 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane1: Mouse stomach tissue lysate Lane2: Mouse heart tissue lysate Lane3: Mouse liver tissue lysate Lane4: HT-29 cell lysate Lysates: 40 ug per lane Primary antibody: 1/200dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-15 antibody

Predicted band size: 76 kDa . Positive control: Mouse heart tissue lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/250dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 90 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-15 antibody

Western blot analysis on MDA-MB-435 cell lysate using MMP15 Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-15 antibody

Western blot (WB) analysis of MMP-15 antibody (Cat.-No.: AP06228PU-N) in extracts from MDA-MB-435 cells. Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MMP-15 (N-term) antibody

The anti-MMP15 N-term Antibody is used in Western blot to detect MMP15 in mouse brain tissue lysate (lane 1) and HL60 cell lysate (lane 2) lysate. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MMP-15 antibody

The MMP15 polyclonal antibody ( Cat # PAB4783 ) is used in Western blot to detect MMP15 in mouse brain tissue lysate ( lane 1 ) and HL-60 cell lysate ( lane 2 ) . Rabbit Hu, Ms E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

MMP-15 antibody

Immunohistochemical staining of MMP15 on formalin fixed, paraffin embedded human placenta with Mmp15 polyclonal antibody. Rabbit Hu P, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

MMP-15 antibody

Western blot analysis of extracts from MDA-MB-435 cells, using MMP-15 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

MMP-15 antibody

Western blot analysis of extracts from MDA-MB-435 cells, using MMP-15 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

MMP-15 (cleaved) antibody

Western blot analysis of extracts from COS7 cells, treated with etoposide 25uM 1h, using MMP15 (Cleaved-Tyr132) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

MMP-15 (cleaved) antibody

Western blot analysis of extracts from COS7 cells, treated with etoposide 25uM 1h, using MMP15 (Cleaved-Tyr132) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

MMP-15 antibody

Western blot analysis of MMP15 expression in HeLa (A); mouse kidney (B); rat kidney (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

MMP-15 antibody

Western blot analysis of MMP15 expression in HeLa (A); mouse kidney (B); rat kidney (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

MMP-15 antibody

Western blot analysis of MMP15 expression in HeLa (A); mouse kidney (B); rat kidney (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

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