MMP-16 antibody

Principal name

MMP-16 antibody

Alternative names for MMP-16 antibody

Matrix metalloproteinase-16, MMP-X2, MMP16, MMPX2, Membrane-type-3 matrix metalloproteinase

SwissProt ID

O35548 (Rat), P51512 (Human), Q9WTR0 (Mouse)

Gene ID

4325 (MMP16)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Rb (Rabbit), Can (Canine), Mky (Monkey), Por (Porcine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Flow Cytometry (F)

Background of MMP-16 antibody

The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zinc endopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.
MMP16 induces the activation of pro gelatinase A (MMP2). It was identified as a membrane bound Metalloproteinase in normal and tumor cell lines. MMP16 is similar to the other MtMMPs; it contains a furin cleavage site, is membrane bound, and contains a cytoplasmic tail (MT4MMP lacks the tail, and may not be intercalated into the membrane). MMP16 is also known to be "shed" from the membrane in a soluble form. MT1MMP is known to function in activating a number of MMPs, chiefly MMP2, but that role has not been well described for the other MTMMPs. MMP16 has been reported to be elevated in several tumor cell lines, and is constituitively produced by some normal cell lines.

General readings

1. Hadchouel A  et al. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. PLoS ONE 3:e3188 (2008). WB ; Human . PubMed: 18784838

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-16 antibody

Western blot analysis of extracts from HepG2 cells, using MMP-16 antibody (#TA311662).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-16 antibody

WB Suggested Anti-MMP16 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MMP-16 antibody

Western blot analysis on HepG2 cell lysate using MMP16 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-16 antibody

Immunohistochemistry (IHC) analyzes of MMP-16  antibody (Cat.-No.: AP06229PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MMP-16 (169-183) antibody

Figure 1. Staining MMP16 in Spleen by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

MMP-16 (C-term) antibody

MMP16 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt C, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

MMP-16 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with MMP16 polyclonal antibody ( Cat # PAB4784 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

MMP-16 antibody

Immunohistochemical staining of MMP16 on formalin fixed, paraffin embedded rat kidney with MMP16 polyclonal antibody ( Cat # PAB12293 ). Rabbit Hu, Ms, Rt C, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

MMP-16 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MMP-16 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

MMP-16 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MMP-16 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

MMP-16 antibody

Human MCF-7; WB Suggested Anti-MMP16 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: MCF7 cell lysate; MMP16 antibody - N-terminal region (ARP46674_P050) in Human MCF-7 cells using Western Blot Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

MMP-16 antibody

MMP-16 Rabbit IgG Aff - Purified Hu, Ms, Rt C, P, WB
0.1 mg / €290.00
  Boster Immunoleader

MMP-16 antibody

Western blot analysis of MMP16 expression in A431 (A); Raw264.7 (B) whole cell lysates. Rabbit Aff - Purified Bov, Can, Chk, Hu, Mky, Ms, Por, Rb, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

MMP-16 antibody

Western blot analysis of MMP16 expression in A431 (A); Raw264.7 (B) whole cell lysates. Rabbit Aff - Purified Bov, Can, Chk, Hu, Mky, Ms, Por, Rb, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

MMP-16 antibody

Western blot analysis of MMP16 expression in A431 (A); Raw264.7 (B) whole cell lysates. Rabbit Aff - Purified Bov, Can, Chk, Hu, Mky, Ms, Por, Rb, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

MMP-16 antibody

MMP-16 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

MMP-16 antibody

Immunohistochemistry: MMP16 Antibody [NBP1-33102] - Immunohistochemical analysis of paraffin-embedded A549 xenograft , using NBP1-33102. Rabbit IgG Hu P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

MMP-16 antibody

MMP-16 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

MMP-16 antibody

MMP-16 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €290.00
  Novus Biologicals Inc.

MMP-16 antibody

Western Blot: MMP16 Antibody [NBP1-69349] - This Anti-MMP16 antibody was used in Western Blot of MCF7 tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rb, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

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