MMP-17 antibody

Principal name

MMP-17 antibody

Alternative names for MMP-17 antibody

Matrix metalloproteinase-17, MMP17, MT4MMP, Membrane-type matrix metalloproteinase 4

SwissProt ID

Q9R0S3 (Mouse), Q9ULZ9 (Human)

Gene ID

4326 (MMP17)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Neutralisation (NEUT)

Background of MMP-17 antibody

The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.MMP17 has been reported to be elevated in several tumor cell lines, and is constituitively produced by some normal cell lines. Treatment of cells with Concanavolin A or the phorbol ester TPA stimulates production of MMP17 in some cell types, and the enzyme can be recovered in cell lysates. Shed forms of MMP17 have also been reported.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-17 antibody

Western blot analysis of extracts from A549 cells, treated with etoposide (25uM, 1hour), using MMP17 (Cleaved-Gln129) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-17 antibody

Predicted band size: 58 kDa . Positive control: K562 cell and human colon cancer tissue lysate. Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-17 antibody

Predicted band size: 58 kDa . Positive control: Human colon cancer tissue lysate. Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-17 antibody

Western Blot: MMP17 Antibody - Western Blot was performed using affinity purified SEQer MMP17 antibody. The lanes contain 5-30ug of a whole cell extract.  Final concentration of antibodies = 0.1ug/ml (1:10,000 dilution). The blot was probed overnight with the SEQer MMP17 antibody.  Blot was then washed according to protocol and probed with goat-anti-Rabbit-HRP conjugate at 1:5000 dilution, washed and developed using chemiluminescence (film exposure 5-30sec).  The protein was detected as represented by the band shown. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-17 antibody

MMP-17 Mouse IgG2 12N24 Purified Hu E, NEUT
0.1 mg / €440.00
  Acris Antibodies GmbH

MMP-17 (409-423) antibody

Figure 1. Staining MMP17 in Small intestine by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

MMP-17 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MMP-17 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with MMP17 polyclonal antibody ( Cat # PAB4785 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

MMP-17 (cleaved) antibody

Western blot analysis of extracts from A549 cells, treated with etoposide 25uM 1h, using MMP17 (Cleaved-Gln129) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

MMP-17 (cleaved) antibody

Western blot analysis of extracts from A549 cells, treated with etoposide 25uM 1h, using MMP17 (Cleaved-Gln129) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

MMP-17 antibody

Western Blot: MMP17 Antibody [22680002] - Western Blot was performed using affinity purified SEQer MMP17 antibody. The lanes contain 5-30ug of a whole cell extract.  Final concentration of antibodies = 0.1ug/ml (1:10,000 dilution). The blot was probed overnight with the SEQer MMP17 antibody.  Blot was then washed according to protocol and probed with goat-anti-Rabbit-HRP conjugate at 1:5000 dilution, washed and developed using chemiluminescence (film exposure 5-30sec).  The protein was detected as represented by the band shown. Rabbit Hu E, WB
50 µg / €440.00
  Novus Biologicals Inc.

MMP-17 antibody

Immunohistochemistry: MMP-17 Antibody (EP1270Y) [NB110-57217] - Immunohistochemical staining of paraffin-embedded human lymphoma using anti-MMP-17 (cat. #110-57217). Rabbit IgG EP1270Y Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MMP-17

MMP-17 Human
10 µg / €580.00
  Abnova Taiwan Corp.

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