Alternative names for MMP-18 antibody
Matrix metalloproteinase-18, MMP18, Collagenase-4, xCol4, col4
Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB)
Background of MMP-18 antibody
All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are are a family of at least eighteen secreted and membrane bound zinc endopeptidases that degrade various components of the ECM, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion.