MMP-2 antibody

Principal name

MMP-2 antibody

Alternative names for MMP-2 antibody

MMP2, CLG4A, 72 kDa gelatinase, Matrix metalloproteinase-2, Gelatinase A, TBE-1, 72 kDa type IV collagenase

SwissProt ID

P08253 (Human), P33434 (Mouse), P33436 (Rat), P50757 (Rabit), Q90611 (Chick), Q9GLE5 (Bovin)

Gene ID

81686 (Mmp2), 4313 (MMP2), 17390

Available reactivities

Rt (Rat), Hu (Human), Bov (Bovine), Ms (Mouse), Ze (Zebrafish), Can (Canine), Por (Porcine), Rb (Rabbit), Chk (Chicken)

Available hosts

Mouse, Rabbit, Sheep

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of MMP-2 antibody

The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. In addition, fibronectin-like repeats, a hinge region, and a C terminal hemopexin-like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.
MMP2, also known as Gelatinase A, is a type IV collagenase that specifically cleaves type IV collagen, the major structural component of basement membranes. The metastatic potential of tumor cells has been found to correlate with the activity of this enzyme.

General readings

1. San-Miguel B  et al. Glutamine prevents fibrosis development in rats with colitis induced by 2,4,6-trinitrobenzene sulfonic acid. J Nutr 140:1065-71 (2010). WB ; Rat . PubMed: 20410082

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-2 (C-term) antibody

MMP2 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

MMP-2 antibody

Sample (50 ug of whole cell lysate). A: Mouse brain. 7.5% SDS PAGE. TA308925 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-2 antibody

Western Blot: MMP2 Antibody [TA336592] - Analysis of MMP2 in recombinant MMP2 and injured rat nerve lysate. Rabbit Purified Chk, Hu, Ms, Rt C, F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MMP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA806846)(1:150) Mouse IgG2a OTI4A11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-2 antibody

Detection of MMP2 in a paraffin-embedded human neurofibroma section using MMP2 polyclonal antibody ( Cat # PAB12382, 4 µg/ml ). Rabbit Chk, Hu, Ms, Rt C, E, P, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

MMP-2 antibody

Human placenta stained with Anti-MMP-2 antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

MMP-2 antibody

Human placenta stained with Anti-MMP-2 antibody Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

MMP-2 antibody

Human placenta stained with Anti-MMP-2 antibody Rabbit Purified Hu P

Regular Price: 0.1 ml / €190.00

Special Price: 0.1 ml / €105.00

  Acris Antibodies GmbH

MMP-2 antibody

Immunohistochemistry-paraffin: MMP2 antibody - Detection of MMP-2 staining in formalin-fixed paraffin-embedded human ovary tissue.  Primary antibody was used at 2.5 ug/ml with the avidin-biotin-peroxidase detection method. Mouse IgG1 8B4 Purified Hu, Ms, Rt C, E, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-2 antibody

Western Blot: Metalloproteinase-2 Antibody - Samples: Lane 1 - Human Recombinant MMP-2. Lane 2 - Schwann Cell Culture Medium Run on 10% SDS-PAGE, followed by electroblot to nitrocellulose and slot blot immunolabeling. Antibodies: primary - anti-Metalloproteinase-2, secondary - anti-mouse-biotin. Detection: avidin-HRP. Chromagen: DAB/H202. Mouse IgG1 2C1 Purified Hu, Ms, Rt C, E, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-2 antibody

Western blot analysis of extracts from HT-29 cells, using MMP-2 antibody (#TA326260).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-2 antibody

Western blot analysis of extracts of various cell lines, using MMP2 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-2 antibody

Lanes: Lane 1: 15ug MDA-MB-231 lysate; Lane 2: 15ug MCF7 lysate; Primary Antibody Dilution: 1:1000; Secondary Antibody: Anti-rabbit-HRP; Secondary Antibody Dilution: 1:10,000; Gene Name: MMP2; Submitted by: Katarzyna Augoff, University of Wroclaw; Rabbit IgG Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-2 antibody

Western blot analysis of extracts of various cell lines, using MMP2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-2 antibody

Western blot analysis on LOVO cell lysate using MMP2 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MMP2 (RC200720, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MMP2.(1:2000) Mouse IgG2a OTI4B11 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MMP-2 antibody

Staining of FFPE Human skin (10x and 40x) with MMP-2 Antibody Cat.-No AF6810 (Clone 42-5D11) at 2 µg/ml. Antibody positive in cytoplasm of interstitial fibroblasts. Mouse IgG1 42-5D11 Purified Hu C, P, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

MMP-2 antibody

Left: Immunohistochemical staining of human oesophageal adenocarcinoma tissue using MMP-2 antibody. Right: Western blot using MMP-2 antibody on recombinant MMP-2 proenzyme (400 ng/lane). Mouse IgG1 4D3 Purified Hu C, E, WB
0.2 mg / €340.00
  Acris Antibodies GmbH

MMP-2 antibody

MMP-2 Mouse IgG1 SB13a HRP Hu C, E, P
1 ml / €470.00
  Acris Antibodies GmbH

MMP-2 antibody

MMP-2 Mouse IgG1 SB13a Purified Hu C, E, P
0.1 mg / €300.00
  Acris Antibodies GmbH

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