MMP-26 antibody

Principal name

MMP-26 antibody

Alternative names for MMP-26 antibody

Matrix metalloproteinase-26, Matrilysin-2, Endometase, MMP26

SwissProt ID

Q9NRE1 (Human)

Gene ID

56547 (MMP26), 7156547 (atpC)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MMP-26 antibody

Matrix metalloproteinase 26 preprotein; gelatinase A; 70kD type IV collagenase; gelatinase neutrophil. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP26 degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP26, also known as Matrilysin 2, was first cloned from human fetal cells, and identified as an MMP most closely related to MMP7 (Matrilysin 1). The homology between MMP7 and MMP26 is low (only 38% identical), thus the functions are unlikely to be similar. Homology is much higher (48% identical) for the comparable region of MMP12, but MMP26 appears to have broader substrate specificity than does MMP12. MMP26, like MMP7, lacks the hemopexin domain common to the other MMPs, but contains a Propeptide domain, cysteine switch activation site, followed by a catalytic domain, and a short vestige of the hinge region. MMP26 is apparently not glycosylated, and is a secreted MMP. Tissue analysis shows MMP26 most strongly in placenta and uterus, but also in kidney cells, lung cells, lymphocytes and lung or endometrial carcinoma cells. MMP26 is proteolytically active, cleaving casein in zymograms, and gelatin, a1PI, fibrinogen, fibronectin, vitronectin, type IV collagen, and apparently activating MMP9. The proteolytic activity was blocked by TIMP1 and TIMP2. MMP26 does not appear to be produced by most normal quiescent cells, but treatment of many cell types with the phorbol ester TPA, or IL1 stimulates production of MMP26.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-26 antibody

Predicted band size: 30 kDa . Positive control: 293T cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 60 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-26 antibody

WB Suggested Anti-MMP26 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: A549 cell lysateMMP26 is supported by BioGPS gene expression data to be expressed in A549 Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

MMP-26 antibody

MMP26 monoclonal antibody (M01), clone 6C6. Western Blot analysis of MMP26 expression in HeLa(Cat # L013V1 ). Mouse IgG2a 6C6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MMP-26 antibody

MMP-26 Mouse IgG1 3B9 Purified Hu E, WB
50 µg / €370.00
  Abnova Taiwan Corp.

MMP-26 antibody

MMP-26 Mouse IgG1 3B9 Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

MMP-26 (C-term) antibody

MMP-26 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

MMP-26 antibody

MMP-26 Rabbit IgG Hu WB
0.1 ml / €340.00
  Novus Biologicals Inc.

MMP-26 antibody

Immunohistochemistry-Paraffin: MMP26 Antibody [NBP1-92127] Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MMP-26

MMP-26 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MMP-26

MMP-26 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MMP26 overexpression lysate

MMP26 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

11 Item(s)

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