MMP-8 antibody

Principal name

MMP-8 antibody

Alternative names for MMP-8 antibody

Neutrophil collagenase, Matrix metalloproteinase-8, PMNL collagenase, MMP8, CLG1, PMNL-CL

Selected pictures

MMP-8 antibody - H00004317-B01
H00004317-B01 - MMP8 MaxPab polyclonal antibody. Western Blot analysis of MMP8 expression in human liver.
MMP-8 antibody - H00004317-B01
H00004317-B01 - Western Blot analysis of MMP8 expression in transfected 293T cell line (H00004317-T01) by MMP8 MaxPab polyclonal antibody.Lane 1: MMP8 transfected lysate(51.37 KDa).Lane 2: Non-transfected lysate.

SwissProt ID

O70138 (Mouse), O88766 (Rat), P22894 (Human)

Gene ID

4317 (MMP8), 63849 (Mmp8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Mouse, Rabbit, Chicken

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MMP-8 antibody

Matrix Metalloproteinase 8 (MMP8) is also known as neutrophil collagenase and collagenase 2. MMP8 degrades fibrillar collagens types I, II, III, aggrecan, serpins and alpha 2 macroglobulin. All collagenases cleave fibrillar collagens at one specific site resulting in generation of N terminal three quarter and C terminal one quarter fragments, which then denature to gelatin at body temperature. The substrate specificity of collagenases is variable: MMP1 degrades type III collagen more efficiently than type I or type II collagen, whereas MMP8 is more potent in degrading type I collagen than type III or type II collagen. MMP13, in turn degrades type II collagen 6 fold more efficiently than type I and type II collagens and displays almost 50 fold stronger gelatinolytic activity than MMP1 and MMP8. MMP8 is very similar to MMP1, sharing 57 % amino acid identity. Most cell types do not produce MMP8. Until recently, it was thought that MMP8 was produced exclusively by neutrophils, but it has also been detected in other cell types including arthritic chondrocytes and gingival fibroblasts. The human MMP8 gene has the chromosomal location of 11q22.2-22.3. MMP8 is heavily glycosylated, and the zymogen has a mass of 85 Kd. The zymogen is quickly activated to the 64 Kd form, and this breaks down to a cascade of active forms.

General readings

1. Clark RT  et al. T cell production of matrix metalloproteases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain. ASN Neuro : (2010). Flow Cyt, IHC-Fr ; Mouse . PubMed: 21133852)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
17874-1-AP

MMP-8 antibody

Immunohistochemical of  paraffin-embedded human placenta using 17874-1-AP(MMP8 antibody) at dilution of 1:100 (under 40x lens) Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.15 ml / €285.00
  Proteintech Group, Inc.
AF8310

MMP-8 antibody

MMP-8 Mouse IgG1 115-13D2 Purified Hu C, P, WB
0.1 mg / €360.00
  Acris Antibodies GmbH
AP06235PU-N

MMP-8 antibody

Immunohistochemistry (IHC) analyzes of MMP-8 antibody (Cat.-No.: AP06235PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH
AP07218PU-N

MMP-8 (hinge region) antibody

Heart: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Mky, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH
AP13186PU-N

MMP-8 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €360.00
  Acris Antibodies GmbH
AP23348PU-N

MMP-8 (N-term) antibody

MMP8 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH
AP26349PU-N

MMP-8 antibody

MMP-8 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH
GTX11607

MMP-8 antibody

MMP-8 Rabbit IgG Aff - Purified Hu E, IP, P, WB
25 µg / €290.00
  GeneTex Inc.
GTX11608

MMP-8 antibody

MMP-8 Rabbit IgG Aff - Purified Hu E, IP, WB
50 µg / €340.00
  GeneTex Inc.
GTX52476

MMP-8 antibody

MMP-8 Mouse IgG2 7A11 Supernatant Hu C, WB
0.1 mg / €450.00
  GeneTex Inc.
GTX61732

MMP-8 antibody

A. Western blot analysis on rat lung using anti-MMP8 RabMAb (cat. # GTX61732) dilution 1:2000. Rabbit IgG EP1252Y Supernatant Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 ml / €420.00
  GeneTex Inc.
GTX82074

MMP-8 antibody

MMP-8 Chicken IgY Aff - Purified Hu WB
50 µg / €500.00
  GeneTex Inc.
GTX105428

MMP-8 antibody

Immunohistochemical analysis of paraffin-embedded Hepatoma, using MMP8(GTX105428) antibody at 1:500 dilution. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €350.00
  GeneTex Inc.
GTX113780

MMP-8 antibody

Sample (30 ug of whole cell lysate)  A: A549  10% SDS PAGE  GTX113780 diluted at 1:500 Rabbit Aff - Purified Hu WB
0.1 ml / €350.00
  GeneTex Inc.


Sample size available for 25µl / 119€
read more…

H00004317-B01

MMP-8 antibody

MMP8 MaxPab polyclonal antibody. Western Blot analysis of MMP8 expression in human liver. Mouse Serum Hu E(detection), WB
50 µl / €360.00
  Abnova Taiwan Corp.
H00004317-B01P

MMP-8 antibody

MMP8 MaxPab polyclonal antibody. Western Blot analysis of MMP8 expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €360.00
  Abnova Taiwan Corp.
H00004317-D01

MMP-8 antibody

MMP-8 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.
H00004317-D01P

MMP-8 antibody

Western Blot analysis of MMP8 expression in transfected 293T cell line (H00004317-T01) by MMP8 MaxPab polyclonal antibody.

Lane 1: MMP8 transfected lysate(53.40 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.
PAB4797

MMP-8 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with MMP8 polyclonal antibody ( Cat # PAB4797 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.
PAB9551

MMP-8 antibody

MMP-8 Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

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