MMP-8 antibody

Principal name

MMP-8 antibody

Alternative names for MMP-8 antibody

Neutrophil collagenase, Matrix metalloproteinase-8, PMNL collagenase, MMP8, CLG1, PMNL-CL

SwissProt ID

O70138 (Mouse), O88766 (Rat), P22894 (Human)

Gene ID

4317 (MMP8), 63849 (Mmp8), 17394

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MMP-8 antibody

MMP8 (Matrix metalloproteinase 8) is a member of the family of matrix metalloproteinases. It is distinct from the collagenase of skin fibroblasts and synovial cells in substrate specificity and immunologic crossreactivity. MMP8 was mapped to 11q21-q22. MMP8 is an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. The enzyme exhibits 58% homology to human fibroblast collagenase and has the same domain structure. It consists of a 20-residue signal peptide, and an 80-residue propeptide that is lost on autolytic activation by cleavage of an M-L bond. MMP8 was found to possess 57% identity with the deduced protein sequence for fibroblast collagenase with 72% chemical similarity. Matrix metalloproteinases (MMPs) have fundamental roles in tumor progression, but most clinical trials with MMP inhibitors have not shown improvements in individuals with cancer. MMP8 has a paradoxical protective role in cancer and provides a genetic model to evaluate the molecular basis of gender differences in cancer susceptibility.

General readings

1. Clark RT  et al. T cell production of matrix metalloproteases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain. ASN Neuro : (2010). Flow Cyt, IHC-Fr ; Mouse . PubMed: 21133852)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-8 antibody

Western blot analysis of extracts from NIH/3T3 cells, using MMP-8 antibody (#TA314204).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-8 antibody

Predicted band size: 53 kDa . Positive control: 231 cell lysate. Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-8 antibody

Western blot analysis on NIH-3T3 cell lysate using MMP8 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-8 antibody

MMP-8 Mouse IgG1 115-13D2 Purified Hu C, P, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

MMP-8 antibody

Immunohistochemistry (IHC) analyzes of MMP-8 antibody (Cat.-No.: AP06235PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MMP-8 (hinge region) antibody

Heart: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Mky, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MMP-8 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MMP-8 (N-term) antibody

MMP8 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

MMP-8 antibody

MMP-8 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH

MMP-8 antibody

MMP8 MaxPab polyclonal antibody. Western Blot analysis of MMP8 expression in human liver. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

MMP-8 antibody

MMP8 MaxPab polyclonal antibody. Western Blot analysis of MMP8 expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

MMP-8 antibody

MMP-8 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

MMP-8 antibody

Western Blot analysis of MMP8 expression in transfected 293T cell line (H00004317-T01) by MMP8 MaxPab polyclonal antibody.

Lane 1: MMP8 transfected lysate(53.40 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

MMP-8 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with MMP8 polyclonal antibody ( Cat # PAB4797 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

MMP-8 antibody

MMP-8 Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

MMP-8 antibody

The whole cell lysate derived from SJCRH30 ( human myosacorma ) was resolved on 10% SDS-PAGE, and transferred onto NC membrane, and probed by MMP8 polyclonal antibody ( Cat # PAB12713 ) at 1 : 100. An immunoreactive band at ~65 kDa was observed ( A ). This immunoreactive band is blocked by pre-incubation with the immunizing peptide ( B ). Rabbit Hu C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

MMP-8 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MMP-8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

MMP-8 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MMP-8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

MMP-8 antibody

Immunohistochemical analysis of MMP8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

MMP-8 antibody

Immunohistochemical analysis of MMP8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

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