MMP-8 antibody

Principal name

MMP-8 antibody

Alternative names for MMP-8 antibody

Neutrophil collagenase, Matrix metalloproteinase-8, PMNL collagenase, MMP8, CLG1, PMNL-CL

SwissProt ID

O70138 (Mouse), O88766 (Rat), P22894 (Human)

Gene ID

4317 (MMP8), 63849 (Mmp8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MMP-8 antibody

Matrix Metalloproteinase 8 (MMP8) is also known as neutrophil collagenase and collagenase 2. MMP8 degrades fibrillar collagens types I, II, III, aggrecan, serpins and alpha 2 macroglobulin. All collagenases cleave fibrillar collagens at one specific site resulting in generation of N terminal three quarter and C terminal one quarter fragments, which then denature to gelatin at body temperature. The substrate specificity of collagenases is variable: MMP1 degrades type III collagen more efficiently than type I or type II collagen, whereas MMP8 is more potent in degrading type I collagen than type III or type II collagen. MMP13, in turn degrades type II collagen 6 fold more efficiently than type I and type II collagens and displays almost 50 fold stronger gelatinolytic activity than MMP1 and MMP8. MMP8 is very similar to MMP1, sharing 57 % amino acid identity. Most cell types do not produce MMP8. Until recently, it was thought that MMP8 was produced exclusively by neutrophils, but it has also been detected in other cell types including arthritic chondrocytes and gingival fibroblasts. The human MMP8 gene has the chromosomal location of 11q22.2-22.3. MMP8 is heavily glycosylated, and the zymogen has a mass of 85 Kd. The zymogen is quickly activated to the 64 Kd form, and this breaks down to a cascade of active forms.

General readings

1. Clark RT  et al. T cell production of matrix metalloproteases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain. ASN Neuro : (2010). Flow Cyt, IHC-Fr ; Mouse . PubMed: 21133852)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-8 antibody

Western blot analysis of extracts from NIH/3T3 cells, using MMP-8 antibody (#TA314204).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-8 antibody

Predicted band size: 53 kDa. Positive control: HT-29 and 231 cell lysate. Recommended dilution: 1/1000-5000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-8 antibody

Predicted band size: 53 kDa . Positive control: 231 cell lysate. Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MMP-8 antibody

Western blot analysis on NIH-3T3 cell lysate using MMP8 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MMP-8 antibody

MMP-8 Mouse IgG1 115-13D2 Purified Hu C, P, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

MMP-8 antibody

Immunohistochemistry (IHC) analyzes of MMP-8 antibody (Cat.-No.: AP06235PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MMP-8 (hinge region) antibody

Heart: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Mky, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MMP-8 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MMP-8 (N-term) antibody

MMP8 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

MMP-8 antibody

MMP-8 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH

MMP-8 antibody

MMP8 MaxPab polyclonal antibody. Western Blot analysis of MMP8 expression in human liver. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

MMP-8 antibody

MMP8 MaxPab polyclonal antibody. Western Blot analysis of MMP8 expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

MMP-8 antibody

MMP-8 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

MMP-8 antibody

Western Blot analysis of MMP8 expression in transfected 293T cell line (H00004317-T01) by MMP8 MaxPab polyclonal antibody.

Lane 1: MMP8 transfected lysate(53.40 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

MMP-8 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with MMP8 polyclonal antibody ( Cat # PAB4797 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

MMP-8 antibody

MMP-8 Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

MMP-8 antibody

The whole cell lysate derived from SJCRH30 ( human myosacorma ) was resolved on 10% SDS-PAGE, and transferred onto NC membrane, and probed by MMP8 polyclonal antibody ( Cat # PAB12713 ) at 1 : 100. An immunoreactive band at ~65 kDa was observed ( A ). This immunoreactive band is blocked by pre-incubation with the immunizing peptide ( B ). Rabbit Hu C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

MMP-8 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MMP-8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

MMP-8 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MMP-8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

MMP-8 antibody

Immunohistochemical analysis of MMP8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

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