MMP-9 antibody

Principal name

MMP-9 antibody

Alternative names for MMP-9 antibody

Matrix metalloproteinase-9, MMP9, 92 kDa type IV collagenase, 92 kDa gelatinase, GELB, Gelatinase B, CLG4B

SwissProt ID

P14780 (Human), P41245 (Mouse), P41246 (Rabit), P50282 (Rat), P52176 (Bovin)

Gene ID

4318 (MMP9), 17395 (Mmp9), 81687

Available reactivities

GP (Guinea Pig), Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Marmoset, Hst (Hamster), Mky (Monkey)

Available hosts

Rabbit, Mouse, Sheep, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP)

Background of MMP-9 antibody

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade extracellular matrix proteins . They are secreted as zymogens (Pro-MMPs) that are activated by a variety of proteinases or by reaction with organic mercurials. They are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs) and by 2-macroglobulin . The regulation of MMP activity is important in tissue remodeling, inflammation, tumor growth and metastasis .

Human MMP-9 (also known as gelatinase B) is secreted as a 92 kDa zymogen . Cleavage of Pro-MMP-9 at or near residue 87 results in the active enzyme with a mass of approximately 82 kDa . MMP-9 has three fibronectin type II domains, a hemopexin-like domain and a proline-rich type V collagen-homologous domain . Pro-MMP-9 can be activated by MMP-3 or by certain bacterial proteinases . MMP-9 is inhibited by.2-macroglobulin or by TIMP-1 , which binds to Pro-MMP-9 as well as to active MMP-9 . In vitro treatment of Pro-MMP-9 with 4-aminophenylmercuric acid (APMA) produces not only the 82 kDa active enzyme but also a C-terminal truncated form of approximately 65 kDa with the activity comparable to that of the 82 kDa form .

Pro-MMP-9 is secreted by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts, chondrocytes, skeletal muscle satellite cells, endothelial cells, and various tumor cells(1, 7- 21). Pro-MMP-9 expression is upregulated by TGF-.1, IL-1., TGF-., PDGF-AB, TNF-., and IL-1. . Substrates for MMP-9 include denatured collagen type I (gelatin), native collagens type IV, V, VII, X and XI, fibrinogen, vitronectin, IL-1., and entactin, a molecule that bridges laminin and type IV collagen .

General readings

Wilhelm, S.M. et al. (1989) J. Biol. Chem. 264:17213.

Matrisian, L.M. (1992) BioEssays 14:455.

Birkedal-Hansen, H. et al. (1993) Crit. Rev. Oral Biol. Med. 4:197.

Birkedal-Hansen, H. (1995) Curr. Opin. Cell Biol. 7:728.

Ogata, Y. et al. (1992) J. Biol. Chem. 267:3581.

Sires, U.I. et al. (1993) J. Biol. Chem. 268:2069.

Lyons, J.G. et al. (1993) J. Biol. Chem. 268:19143.

Okada, Y. et al. (1995) Lab. Invest. 72:311.

Tamura, T. et al. (1996) Endocrinology 137:3729.

Okamoto, T. et al. (1997) J. Biol. Chem. 272:6059.

O’Connell, J.P. et al. (1994) J. Biol. Chem. 269:14967.

Koide, H. et al. (1996) Am. J. Kidney Dis. 28:32.

Hirose, T. et al. (1992) J. Rheumatol. 19:593.

Iwata, H. et al. (1996) Jpn. J. Cancer Res. 87:602.

Cullen, B. et al. (1997) Int. J. Biochem. Cell Biol. 29:241.

Guerin, C.W. and P.C. Holland (1995) Dev. Dyn. 202:91.

Hanemaaijer, R. et al. (1993) Biochem. J. 296:803.

Maeda, A. and R.A. Sobel (1996) J. Neuropathol. Exp. Neurol. 55:300.

Gress, T.M. et al. (1995) Int. J. Cancer 62:407.

Ueda, Y. et al. (1996) Am. J. Pathol. 148:611.

Lyons, J.G. et al. (1991) Biochemistry 30:1449.

Imai, K. et al. (1994) FEBS Lett. 369:249.

Ito, A. et al. (1996) J. Biol. Chem. 271:14657.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MMP-9 antibody

Staining of Human prostatic adenocarcinoma with MMP-9 Antibody Cat.-No AF6910 (Clone 56-2A4) at 2 µg/ml. Antibody positive in cytoplasma and in lumen secreted. 40x Mouse IgG1 56-2A4 Purified Hu C, P, WB
0.1 mg / €300.00
  OriGene Technologies GmbH

MMP-9 antibody

  Mouse Monoclonal Anti-MMP9 Antibody  
MMP-9 Mouse IgG2a S51-82 Purified Hu, Ms, Rt C, IP, WB
0.1 mg / €410.00
  OriGene Technologies, Inc.

MMP-9 antibody

  Mouse Monoclonal MMP-9 Antibody (4A3)  
Western Blot: MMP9 Antibody (4A3) [TA336901] - Western blot analysis of activated MMP9 expression in MMP9 proenzyme incubated with trypsin for various times. Mouse IgG1 4A3 Purified Hu, Rt C, E, P, WB
0.1 ml / €416.00
  OriGene Technologies, Inc.

MMP-9 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2a L51/82 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €460.00
  Antibodies Incorporated

NeuroMab

MMP-9 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2a L51/82 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €540.00
  Antibodies Incorporated

NeuroMab

MMP-9 antibody

MMP-9 Mouse IgG2a SB15c HRP Hu C, E, P
1 ml / €440.00
  OriGene Technologies GmbH

MMP-9 antibody

Immunohistochemistry (Paraffin-Embedded Sections): Human colon tissue stained with AM08200PU-N at 5 µg/ml. Mouse IgG2a SB15c Purified Hu C, E, P
0.1 mg / €300.00
  OriGene Technologies GmbH

MMP-9 antibody

MMP-9 Goat Aff - Purified Ms, Rt C, E, IP, P, WB
0.1 mg / €450.00
  Neuromics Antibodies

MMP-9 antibody

MMP-9 Rabbit Purified Rt C, IP, WB
0.2 mg / €290.00
  Torrey Pines Biolabs

9 Item(s)

per page
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