MPZ antibody

Principal name

MPZ antibody

Alternative names for MPZ antibody

Myelin P0 protein, Myelin protein zero, Myelin peripheral protein, MPP

SwissProt ID

P06907 (Rat), P10522 (Bovin), P25189 (Human), P27573 (Mouse), P37301 (Chick)

Gene ID

4359 (MPZ), 24564 (Mpz)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Chicken, Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of MPZ antibody

MPZ (myelin protein zero), also known as P0, a transmembrane glycoprotein (~30 kDa), is a member of the immunoglobulin supergene family. Synthesized by myelin-forming Schwann cells, MPZ is the major structural protein component of myelin in the peripheral nervous system. It is involved in formation and maintence of compact myelin, and plays a role in the creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae. More than 120 mutations detected in the gene of MPZ cause various forms of hereditary neuropathy, which include Charcot-Marie-Tooth disease type 1B (CMT1B), CMT2, Dejerine-Sottas syndrome (DSS), and congenital hypomyelition neuropathy (CHN). This antibody can recognize endogenous MPZ, and can be used as a marker of myeliting Schwann cells.

General readings

LeBlanc SE, Ward RM, Svaren J.
Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10.
Mol Cell Biol. 2007 May;27(9):3521-9. Epub 2007 Feb 26.
PMID: 17325040

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MPZ (C-term) antibody

MPZ Antibody (C-term) (AP18120PU-N)  Immunohistochemistry analysis in formalin fixed and Paraffin Embedded Human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MPZ Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Purified Hu F, P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

MPZ antibody

TA303265 (0.1µg/ml) staining of Rat Spinal Cord lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MPZ antibody

Predicted cell location: Cell membrane,Cytoplasm . Positive control: Human cervical cancer tissue . Recommended dilution: 1/5-20  The image on the left is immunohistochemistry of paraffin-embedded human cervical cancer tissue using MPZ antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MPZ antibody

Predicted cell location: Cell membrane,Cytoplasm . Positive control: Human cancer tissue . Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human cancer tissue using MPZ antibody at dilution 1/5, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MPZ antibody

Western blot analysis of extracts of Schwann cell lines, using MPZ antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MPZ antibody

In the Left panel (a tissue section through an adult sciatic nerve), Po (green staining) can be seen in the myelin and Schwann cell processes surrounding the nodes of Ranvier. In this photomicrograph, Rabbit antibodies against LAMP (lysozome-associated membrane glycoprotein) (red staining) serves as the counterstain, and DAPI (blue staining) allows visualization of nuclei. In the Right panel (a lower power tissue section through an adult sciatic nerve), Po (brown staining) can be seen in all of the myelinating Schwann cells. Chicken Ig Aff - Purified Hu, Ms ICC/IF, P, WB
0.2 mg / €440.00
  Acris Antibodies GmbH

MPZ antibody

MPZ Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MPZ antibody

Detection limit for recombinant GST tagged MPZ is approximately 1ng/ml as a capture antibody. Mouse IgG2a 3B12 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

MPZ antibody

MPZ polyclonal antibody ( Cat # PAB7332 ) ( 0.1 µg/ml ) staining of rat spinal cord lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Rt E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

MPZ antibody

Western blot analysis of MPZ expression in HeLa (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

MPZ antibody

Western blot analysis of MPZ expression in HeLa (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

MPZ antibody

Western blot analysis of MPZ expression in HeLa (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

MPZ antibody

(a tissue section through an adult sciatic nerve), Po (green staining) can be seen in the myelin and Schwann cell processes surrounding the nodes of Ranvier. In this photomicrograph, rabbit antibodies against LAMP (lysozome-associated membrane glycoprotein) (red staining) serves as the counterstain, and DAPI (blue staining) allows visualization of nuclei. Chicken Aff - Purified Hu, Ms C, ICC/IF, WB
0.1 ml / €180.00
  Neuromics Antibodies

MPZ antibody

Adult sciatic nerve, Po stained (green) can be seen in the myelin and Schwann cell processes surrounding the nodes of Ranvier. In this photomicrograph, rabbit antibodies against LAMP (red), and DAPI (blue) allows visualization of nuclei. Chicken Aff - Purified Ms ICC/IF, P, WB
0.25 ml / €340.00
  Novus Biologicals Inc.

MPZ antibody

Western Blot: Myelin Protein Zero Antibody [NB100-94909] - staining of Rat Spinal Cord lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MPZ

MPZ Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MPZ

MPZ Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

MPZ

MPZ Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MPZ

MPZ Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MPZ overexpression lysate

MPZ overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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