MSH2 antibody

Principal name

MSH2 antibody

Alternative names for MSH2 antibody

DNA mismatch repair protein Msh2, MutS protein homolog 2

SwissProt ID

P25847 (Yeast), P43246 (Human), P43247 (Mouse), P54275 (Rat), Q3MHE4 (Bovin)

Gene ID

4436 (MSH2), 2854063 (cbiO), 4286 (MITF)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), Dros (Drosophila), Ye (Yeast), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of MSH2 antibody

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.

General readings

Kim, M. et al., Cancer Sci. 101(11): 2436-2442 (2010)
Mangoni, M. et al., Int. J. Radiat. Oncol. Biol. Phys. 81(1): 52-58 (2010)
Srivastava, K. et al., Cancer 116(13): 3160-3169 (2010)
van der Post, R.S. et al., J. Med. Genet. 47(7): 464-470 (2010)
Langner, E.,et al., J. Genet. 89(1): 101-104 (2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MSH2 antibody

Immunohistochemistry-Paraffin: MSH2 Antibody [NB100-1767] Mouse IgG1 3A2B8C Purified Hu, Mky E, ICC/IF, P, WB
0.1 mg / €380.00
  Novus Biologicals Inc.

MSH2 (N-term) antibody

Retained MSH2 expression in the colorectal adenocarcinoma, stained with DB 115, anti-human MSH2 monospecific antibody. Rabbit IgG N29-D Aff - Purified Hu P
0.1 ml / €300.00
  DB Biotech, spol. s r.o.

Sample sizes available

MSH2 (N-term) antibody

Retained MSH2 expression in the colorectal adenocarcinoma, stained with DB 115, anti-human MSH2 monospecific antibody. Rabbit IgG N29-D Aff - Purified Hu P
0.2 ml / €410.00
  DB Biotech, spol. s r.o.

Sample sizes available

MSH2 (N-term) antibody

Retained MSH2 expression in the colorectal adenocarcinoma, stained with DB 115, anti-human MSH2 monospecific antibody. Rabbit IgG N29-D Aff - Purified Hu P
0.5 ml / €520.00
  DB Biotech, spol. s r.o.

Sample sizes available

MSH2 (N-term) antibody

Retained MSH2 expression in the colorectal adenocarcinoma, stained with DB 115, anti-human MSH2 monospecific antibody. Rabbit IgG N29-D Aff - Purified Hu P
1 ml / €810.00
  DB Biotech, spol. s r.o.

Sample sizes available

MSH2 antibody

Human Colon Carcinoma stained with anti-MSH2 Antibody Cat.-No AM11173PU (Clone SP46). Rabbit SP46 Purified Hu F, P
0.5 ml / €520.00
  Acris Antibodies GmbH

MSH2 antibody

Human Colon Carcinoma stained with anti-MSH2 Antibody Cat.-No AM11173PU (Clone SP46). Rabbit SP46 Purified Hu F, P
1 ml / €750.00
  Acris Antibodies GmbH

MSH2 antibody

Human Colon Carcinoma stained with anti-MSH2 Antibody Cat.-No AM11173PU (Clone SP46). Rabbit SP46 Purified Hu F, P
0.1 ml / €290.00
  Acris Antibodies GmbH

MSH2 antibody

Human colon ca stained with Anti-MSH2 Rabbit Purified Hu P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

MSH2 antibody

Human colon ca stained with Anti-MSH2 Rabbit Purified Hu P, WB
1 ml / €520.00
  Acris Antibodies GmbH

MSH2 antibody

Human colon ca stained with Anti-MSH2 Rabbit Purified Hu P, WB
0.1 ml / €190.00
  Acris Antibodies GmbH

MSH2 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using MSH2 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MSH2 (Center) antibody

MSH2 Antibody (Center) (Cat. #TA324411) western blot analysis in SW480,U251 cell line lysates (35ug/lane).This demonstrates the MSH2 antibody detected the MSH2 protein (arrow). Rabbit Ig Aff - Purified Hu F, ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

MSH2 antibody

Western blot analysis of extracts of various cell lines, using MSH2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MSH2 antibody

Immunohistochemistry staining of Paraffin Colon tissue by MSH2 antibody (dilution: 1:100-1:500; visualization of staining: Nuclear) Mouse IgG1 G219-1129 Purified Hu P
1 ml / €560.00
  OriGene Technologies, Inc.

MSH2 antibody

MSH2 Antibody (Center) (Cat. #TA328162) western blot analysis in 293,Hela cell line lysates (35ug/lane).This demonstrates the MSH2 antibody detected the MSH2 protein (arrow). Mouse IgG1 1184CT1.3.2 Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

MSH2 antibody

WB Suggested Anti-MSH2 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1: 62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ye, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MSH2 antibody

WB Suggested Anti-MSH2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

MSH2 antibody

Western blot detection of MSH2 in K562,CEM,Jurkat,293T and A431 cell lysates using MSH2 mouse mAb (1:1000 diluted).Predicted band size:100KDa.Observed band size:100KDa. Mouse IgG2b 4G5-E11-D9 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MSH2 antibody

Immunohistochemical analysis of paraffin-embedded human breast cancer (left) and lung cancer (right) tissues, showing nuclear localization using MSH2 antibody Cat.-No AM06094SU-N with DAB staining. Mouse IgG1 1B3=3A2B8C Ascites Hu, Mky E, P, WB
0.1 ml / €360.00
  Acris Antibodies GmbH

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