MSH4 antibody

Principal name

MSH4 antibody

Alternative names for MSH4 antibody

MutS protein homolog 4

SwissProt ID

O15457 (Human), P40965 (Yeast), Q6DTM5 (Arath), Q99MT2 (Mouse)

Gene ID

4438 (MSH4), 55993 (Msh4)

Available reactivities

Hu (Human), Ms (Mouse), Arabidopsis, Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P)

Background of MSH4 antibody

Six strong homologs of the bacterial MutS DNA mismatch repair (MMR) gene have been identified in the yeast Saccharomyces cerevisiae. With the exception of the MSH1 gene, the involvement of each homolog in DNA repair and recombination during meiosis has been determined previously. Five of the homologs have been demonstrated to act in meiotic DNA repair (MSH2, MSH3, MSH6 and MSH4) and/or meiotic recombination (MSH4 and MSH5). Several strong homologs of bacterial MutS DNA mismatch repair (MMR) genes have been identified (MSH1-MSH6), with the exception of the MSH1 gene, all others have significant role in recombination and DNA repair during meiosis.
MSH4, a meiosis-specific member of the MutS-homolog family of genes, is required for normal levels of recombination and fertility in budding yeast, mouse, and Caenorhabditis elegans. The arabipdosis specific homolog of MSH4 (AtMSH4) in reproduction was characterized in floral tissues (1). The expression of MSH4 in A thaliana is limited to early meiotic phase I preceding the synapsis of homologous chromosomes. The insertion of AT-DNA mutant (ATmsh4) exhibited normal vegetative growth but significant reduction in fertility consistent with meiotic defect which was further confirmed by cytological staining of meiosis. Similar reduction in meiosis was observed with RNAi dependent down regulation of MSH4 which is the result of delayed or incomplete prophase I chromosome sysnapsis and metaphase chiasma frequency is greatly reduced compared to wild type leading to univalence and nondisjunction in budding yeast (1).
MSH4 protein has several function domains in cluding MutS domain III which is found in MutS family of DNA mismatch repair protein and is found associated with pfam00488, pfam05188, pfam01624 and pfam05190; pfam05192. The MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. A thaliana MSH4 protein is a 792 amino acid (98-100kDa) protein expressed din nuclear compartment.

16 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MSH4 antibody

WB Suggested Anti-MSH4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Thymus Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

MSH4 antibody

WB Suggested Anti-MSH4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: PANC1 cell lysateMSH4 is supported by BioGPS gene expression data to be expressed in PANC1 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MSH4 Control Peptide

MSH4
0.1 mg / €250.00
  Acris Antibodies GmbH

MSH4 (N-term) antibody

MSH4 Rabbit Aff - Purified Arabidopsis WB
0.1 mg / €420.00
  Acris Antibodies GmbH

MSH4 Control Peptide

MSH4
0.1 mg / €250.00
  Acris Antibodies GmbH

MSH4 antibody

MSH4 Rabbit Aff - Purified Arabidopsis C, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

MSH4 antibody

MSH4 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MSH4 antibody

MSH4 Rabbit Ms E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

MSH4 antibody

MSH4 Goat Hu, Ms E
0.1 mg / €390.00
  Abnova Taiwan Corp.

MSH4 antibody

Human Thymus; WB Suggested Anti-MSH4 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Thymus; MSH4 antibody - middle region (ARP41354_P050) in Human Thymus cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

MSH4 antibody

Human PANC1; WB Suggested Anti-MSH4 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: PANC1 cell lysate. MSH4 is supported by BioGPS gene expression data to be expressed in PANC1.; MSH4 antibody - N-terminal region (ARP41355_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

MSH4 antibody

Western Blot: MSH4 Antibody [NBP1-58170] - This Anti-MSH4 antibody was used in Western Blot of PANC1     tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

MSH4 antibody

Western Blot: MSH4 Antibody [NBP1-58198] - This Anti-MSH4 antibody was used in Western Blot of Fetal Thymus   tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

MSH4 antibody

Immunohistochemistry-Paraffin: MSH4 Antibody [NBP1-86383] Immunohistochemical staining of human testis shows strong cytoplasmic positivity in leydig cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MSH4

MSH4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MSH4

MSH4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

16 Item(s)

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