MSH6 antibody

Principal name

MSH6 antibody

Alternative names for MSH6 antibody

DNA mismatch repair protein Msh6, GTBP, MutS-alpha 160 kDa subunit, G/T mismatch-binding protein, p160

SwissProt ID

P52701 (Human), P54276 (Mouse), Q03834 (Yeast)

Gene ID

2956 (MSH6), 17688 (Msh6)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Can (Canine), Mky (Monkey), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C), Electrophoretic Mobility Shift Assay (EMSA), Flow Cytometry (F)

Background of MSH6 antibody

The D mismatch repair system (MMR) repairs post-replication D, inhibits recombition between nonidentical D sequences, and induces both checkpoint and apoptotic responses following certain types of D damage. MSH2 (MutS homologue 2) forms the hMutS-a dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-a is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins, and the Rad50-Mre11-NBS1 complex. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world. Mutations in MSH6 have been shown to occur in glioblastoma in response to temozolomide therapy and to promote temozolomide resistance

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Lysates (Knockout)

Catalog No.    

MSH6-knockout Cell lysate

MSH6-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

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