MTNR1A antibody

Principal name

MTNR1A antibody

Alternative names for MTNR1A antibody

MTNR1A, Melatonin receptor type 1A, Mel1a melatonin receptor, Mel-1A-R

SwissProt ID

O02769 (Bovin), O02781 (Pig), P48039 (Human), P48040 (Sheep), P49217 (Phosu), P49218 (Rat), P49285 (Chick), P51048 (Xenla), Q61184 (Mouse)

Gene ID

4543 (MTNR1A), 17773 (Mtnr1a)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Fi (Fish), Hst (Hamster), Marmoset, Mky (Monkey), Op (Opossum), Prim (Primate), Xen (Xenopus), Ze (Zebrafish), Tr (Turkey), L (Lizard), Bear, Sh (Sheep)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Paraffin Sections (P)

Background of MTNR1A antibody

Melatonin (N-acetyl-5-methoxytryptamine) is a product of tryptophan metabolism. It is synthesized in the pineal gland and is secreted to control the circadian rhythm. Melatonin is also synthesized in the gastrointestil tract, reti, skin and other tissues where it acts in a autocrine or paracrine manner. The role of melatonin in these tissues is independent of its role in the circadian rhythm, where it plays a role in energy metabolism, physiological growth, differentiation and responsiveness in stress stimuli. The pleiotropic effects of melatonin have given rise to various therapeutic possibilities for this molecule. For example; anti-stress, sexual dysfunction, obesity, gallbladder stones. To date, the only therapeutic uses for melatonin remain to treat sleep disorders, depression, migraine and headaches. Melatonin exerts its effects through two G-protein coupled receptors (GPCRs); melatonin receptor type 1 and melatonin receptor type 2 (MT1 and MT2). Like all GPCRs, they have seven transmembrane domains and extracellular N-termil and cytoplasmic C-termil tails. The binding of melatonin to either receptor activates Gi, thereby activating PLC, thus increasing intracellular Ca2+ levels. Both receptors structurally bind melatonin in the same manner, although MT2 displays a much higher affinity for the hormone. Just like melatonin levels are detected in many tissues, the expression patterns of the two receptors are also quite broad. For example, MT1 is detected in the brain, reti and kidneys and MT2 is expressed in brain and in the reti. MT1 is involved in sleep regulation and might also have effects on peripheral vasoconstriction. MT2 may play an important physiological role in the reti and might regulate body temperature.

General readings

Adi,N. et.al., Med. Sci. Monit. 16 (2): BR61-BR67 (2010)
Hill,S.M. et.al., Integr Cancer Ther 8 (4): 337-346 (2009)
Lai,L. et.al., Breast Cancer Res. Treat. 118 (2): 293-305 (2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MTNR1A antibody

  Goat Anti-MTNR1A Antibody  
TA305660 (0.3ug/ml) staining of KELLY lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MTNR1A antibody

  Rabbit polyclonal antibody to MEL-1A-R (melatonin receptor 1A)  
Melatonin Receptor 1A antibody detects Melatonin Receptor 1A protein by western blot analysis. Various whole cell extracts (30 µg) were separated by 10% SDS-PAGE, and the membrane was blotted with Melatonin Receptor 1A antibody (GTX100003) diluted at 1:1000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MTNR1A antibody

  Rabbit polyclonal anti-MTR1A antibody  
Immunofluorescence analysis of HepG2 cells, using MTR1A antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

MTNR1A antibody

  Anti-MTNR1A Rabbit Polyclonal Antibody  
Predicted band size: 39 kDa . Positive control: Mouse brain tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 10%SDS-PAGE Lysate: 30 ug Primary antibody: 1/650 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MTNR1A antibody

  Anti-MTNR1A Rabbit Polyclonal Antibody  
Predicted band size: 39 kDa . Positive control: NIH/3T3 cell lysate. Recommended dilution: 1/1000-3000. (Gel: 10%SDS-PAGE Lysate: 30 ug Primary antibody: 1/1700 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MTNR1A antibody

  Rabbit Polyclonal Anti-Melatonin Receptor type 1  
Western blot analysis of mouse brain (lanes 1 and 4) rat brain (lanes 2 and 5) and rat cerebellum (lanes 3 and 6) lysates: 1-3. Anti-Melatonin Receptor Type 1 antibody, (1:200). 4-6. Anti-Melatonin Receptor Type 1 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

MTNR1A (2nd. Cytoplasm. Dom.) antibody

  Rabbit Polyclonal Anti-MTNR1A Antibody (Cytoplasmic Domain)  
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bear, Bov, Can, Fi, Hst, Hu, L, Marmoset, Mky, Ms, Op, Prim, Rt, Tr, Xen, Ze P
50 µg / €400.00
  OriGene Technologies, Inc.

MTNR1A (1st Cytopl. Dom.) antibody

  Rabbit Polyclonal Anti-MTNR1A Antibody (Cytoplasmic Domain)  
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Can, Fi, Hu, L, Mky, Ms, Prim, Rt, Sh, Xen P
50 µg / €400.00
  OriGene Technologies, Inc.

MTNR1A (Center) antibody

Western blot analysis of MTNR1A (arrow) in CEM cell line lysates (35ug/lane) using MTNR1A antibody Cat.-No. AP52769PU-N. Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MTNR1A antibody

Immunofluorescence analysis of HepG2 cells, using MTR1A Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
50 µg / €230.00
  Assay Biotech

MTNR1A antibody

Immunofluorescence analysis of HepG2 cells, using MTR1A Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

MTNR1A - human gene knockout kit via CRISPR

MTNR1A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MTNR1A - human gene knockout kit via CRISPR

MTNR1A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MTNR1A - human gene knockout kit via CRISPR

MTNR1A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MTNR1A - human gene knockout kit via CRISPR

MTNR1A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mtnr1a - mouse gene knockout kit via CRISPR

Mtnr1a - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mtnr1a - mouse gene knockout kit via CRISPR

Mtnr1a - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MTNR1A

  Recombinant protein of human melatonin receptor 1A (MTNR1A)  
MTNR1A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

MTNR1A overexpression lysate

MTNR1A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MTNR1A (mGFP-tagged) - Human melatonin receptor 1A (MTNR1A), 200 uL, >10^7 TU/mL

Lenti ORF particles, MTNR1A (mGFP-tagged) - Human melatonin receptor 1A (MTNR1A), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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