Muscarinic acetylcholine receptor M2 antibody

Principal name

Muscarinic acetylcholine receptor M2 antibody

Alternative names for Muscarinic acetylcholine receptor M2 antibody

CHRM2, mAChR M2, mAChR-M2

SwissProt ID

P06199 (Pig), P08172 (Human), P10980 (Rat), P41985 (Bovin), Q9ERZ4 (Mouse)

Gene ID

397498 (CHRM2), 81645 (Chrm2), 1129, 243764

Available reactivities

Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Bt (Bat), Bov (Bovine), Can (Canine), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Rb (Rabbit), Sh (Sheep), Bear, Chk (Chicken), Eq (Equine), Fi (Fish), Op (Opossum), Xen (Xenopus), Tr (Turkey)

Available hosts

Mouse, Rabbit, Rat, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Functional assay (FN)

Background of Muscarinic acetylcholine receptor M2 antibody

The action of the neurotransmitter acetylcholine is mediated through two types of receptors, the ionotrophic nicotinic receptors and the metabotrophic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-TM G-protein-coupled receptors. Five subtypes of muscarinic receptors have been cloned and are med m1-m5. The muscarinic receptors are widely distributed throughout the body, but are predomintly expressed within the parasympathetic nervous system and exerts both excitatory and inhibitory control over central and peripheral tissues. Muscarinic receptors participate in a number of physiological functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control. They also participate in learning and memory processing. The m2 receptor is considered to be the predomint muscarinic receptor that is expressed in cardiac muscle. The m2 and m4 receptors mediate Ca2+ channel inhibition and Kir3 K+ channel activation by directly binding the Gbg subunit to the channel. Stimulation of the m2 receptor by acetylcholine in the heart results in activation of the Kir3.1/Kir3.4 channels causing a slowing in heart beat.

General readings

This product has been used in:Luetje CW et al. Isolation and characterization of monoclonal antibodies specific for the cardiac muscarinic acetylcholine receptor. Biochemistry 26:6892-6 (1987). PubMed PMID: 3427051
General / background references:Wreggett KA & Wells JW Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors. J Biol Chem 270:22488-99 (1995). PubMed PMID: 7673239
Wang P et al. Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins. J Pharmacol Exp Ther 273:959-66 (1995). PubMed PMID: 7752101

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Muscarinic acetylcholine receptor M2 (3rd cytopl. dom.) antibody

Anti-CHRM2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Fi, GP, Hst, Hu, Mky, Ms, Op, Platypus, Por, Rb, Rt, Sh, Tr, Xen P
50 µg / €379.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M2 (352-364) antibody

(2ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M2 antibody

Western blot analysis of extracts from MCF-7 cells and HeLa cells, using CHRM2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M2 antibody

Predicted cell location: Cytoplasm. Positive control: Human colon cancer tissue. Recommended dilution: 1/5-25  The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CHRM2 antibody at dilution 1/3, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M2 antibody

Western blot analysis of extracts of 293 cell line, using CHRM2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M2 antibody

Western blot analysis of rat brain membranes: 1. Anti-M2 Muscarinic Receptor antibody, (1:200). 2. Anti-M2 Muscarinic Receptor antibody, preincubated with the control fusion protein antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M2 (3rd cytopl. dom.) antibody

Anti-CHRM2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, GP, Hst, Hu, Ms, Op, Por, Rb, Rt, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M2 (3rd cytopl. dom.) antibody

Anti-CHRM2 / M2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, GP, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M2 antibody

Anti-CHRM2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. Rabbit Purified Bt, Can, Eq, GP, Hst, Hu, Ms, Por, Rt
50 µg / €379.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M2 (168-192) antibody

Muscarinic acetylcholine receptor M2 Mouse IgG2a B8E5 Purified GP, Hu, Ms, Rt C, E, FN, ICC/IF, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Muscarinic acetylcholine receptor M2 antibody

Western blot (WB) analysis of Adenosine mAChR M2 antibody (Cat.-No.: AP01304PU-N)  in extracts fromMCF-7 cells. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Muscarinic acetylcholine receptor M2 (C-term) antibody

Lane 1: Rat brain tissue Lysate.
Lane 2: Rat brain tissue Lysate.
Lane 3: Rat medulla tissue Lysate.
Lane 4: Rat medulla tissue Lysate. Rabbit IgG Aff - Purified Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Muscarinic acetylcholine receptor M2 antibody

CHRM2 polyclonal antibody (A01), Lot # O50912JC01 Western Blot analysis of CHRM2 expression in Y-79 ( Cat # L042V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Muscarinic acetylcholine receptor M2 antibody

Muscarinic acetylcholine receptor M2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Muscarinic acetylcholine receptor M2 antibody

Detection limit for recombinant GST tagged CHRM2 is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 4B5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Muscarinic acetylcholine receptor M2 antibody

Immunofluorescence analysis of LOVO cells, using CHRM2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

Muscarinic acetylcholine receptor M2 antibody

Immunofluorescence analysis of LOVO cells, using CHRM2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

Muscarinic acetylcholine receptor M2 antibody

Muscarinic acetylcholine receptor M2 Mouse IgG1 31-1D1 Ascites Hu, Ms, Por, Rt IP, WB
0.125 ml / €400.00
  Novus Biologicals Inc.

Muscarinic acetylcholine receptor M2 antibody

Muscarinic acetylcholine receptor M2 Rat IgG1 2-1-155 Purified Hu, Mky, Ms, Rt C, P
0.1 mg / €340.00
  Novus Biologicals Inc.

Muscarinic acetylcholine receptor M2 antibody

Brain, Neurons and glia: Formalin-Fixed Paraffin-Embedded (FFPE). Rabbit Aff - Purified Hu P
50 µl / €440.00
  Novus Biologicals Inc.

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