Muscarinic acetylcholine receptor M3 antibody

Principal name

Muscarinic acetylcholine receptor M3 antibody

Alternative names for Muscarinic acetylcholine receptor M3 antibody

CHRM3

SwissProt ID

P08483 (Rat), P11483 (Pig), P20309 (Human), P41984 (Bovin), P49578 (Chick), Q9ERZ3 (Mouse)

Gene ID

1131 (CHRM3), 5113152 (aceK), 24260 (Chrm3)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Eq (Equine), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Op (Opossum), Por (Porcine), Rb (Rabbit), Sh (Sheep), Tr (Turkey), L (Lizard), Bear, Gorilla

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Muscarinic acetylcholine receptor M3 antibody

The action of the neurotransmitter acetylcholine is mediated through two types of receptors, the ionotrophic nicotinic receptors and the metabotrophic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-TM G-protein-coupled receptors. Five subtypes of muscarinic receptors have been cloned and med m1-m5. The muscarinic receptors are widely distributed throughout the body, but are predomintly expressed within the parasympathetic nervous system and exerts both excitatory and inhibitory control over central and peripheral tissues. The m3 receptor is expressed in brain, heart, uriry bladder, salivary gland and airway smooth muscle. Muscarinic receptors participate in a number of physiologic functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control. They also participate in learning and memory processing. The m1 receptors are the most abundant muscarinic subtype in the cortex and striatum. m1 receptors were also localized in the myenteric plexus where they function as autoreceptors to enhance the release of Ach from the nerves. m2, found in heart, is coupled to and mediates the slowing of heart rate in response to acetylcholine. m3 controls smooth muscle contraction and its stimulation causes secretion from glandular tissues. Involvement of muscarinic receptors in apoptosis and cell growth has been reported. m1, m3 and m5, which are coupled to Gq/11 proteins, can protect cells from undergoing apoptosis induced by D damage. The sigling mechanism that mediates this anti-apoptotic response is still poorly understood. However, it was recently reported that a poly-basic motif in the C-terminus tail of the m3, m1 and m5 receptors is an essential element for the anti-apoptotic response of those receptors. Muscarinic receptors are also capable of promoting cell proliferation in many cell types, however, the sigling pathways are yet, unclear. In the literature, m3 was reported to be involved in mitogenesis and proliferation of different cell types. Recently, it was reported that activation of the m3 muscarinic receptor induces significant proliferation of colon and prostate cancer cells.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Muscarinic acetylcholine receptor M3 (C-term) antibody

Anti-CHRM3 / M3 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €345.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M3 antibody

Western blot analysis of rat brain lysate: 1. Anti-M3 Muscarinic Receptor antibody, (1:200). 2. Anti-M3 Muscarinic Receptor antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M3 (3rd Cytopl. Dom.) antibody

Heart: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Can, Chk, Elephant, Eq, GP, Hst, Hu, L, Mky, Ms, Op, Por, Prim, Rb, Rt, Sh, Tr E, P
50 µg / €470.00
  Acris Antibodies GmbH

Muscarinic acetylcholine receptor M3 (3rd cytopl. dom) antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Can, Elephant, Eq, Hst, Hu, L, Mky, Ms, Op, Por, Rb, Rt, Sh E, P
50 µg / €470.00
  Acris Antibodies GmbH

Muscarinic acetylcholine receptor M3 (3rd Cytopl. Dom.) antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bear, Elephant, Eq, Hu, Mky, Por, Prim E, P
50 µg / €470.00
  Acris Antibodies GmbH

Muscarinic acetylcholine receptor M3 (3rd Cytopl. Dom) antibody

AP06826PU-N CHRM3 antibody staining of Formalin-Fixed Paraffin-Embedded Human Brain, cortex at 5 µg/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Bear, Chk, Elephant, GP, Hu, L, Ms, Op, Platypus, Por, Prim, Rb, Tr E, P
50 µg / €470.00
  Acris Antibodies GmbH

Muscarinic acetylcholine receptor M3 (3rd Cytopl. Dom.) antibody

Formalin-Fixed Paraffin-Embedded Human Brain, Caudate stained with CHRM3 antibody Cat.-No AP06976PU-N at 10 µg/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, GP, Hst, Hu, L, Mky, Ms, Op, Platypus, Por, Prim, Rb, Rt, Sh, Tr E, P
50 µg / €470.00
  Acris Antibodies GmbH

Muscarinic acetylcholine receptor M3 (580-589) antibody

Muscarinic acetylcholine receptor M3 Rabbit Azide Free Hu, Rt C, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Muscarinic acetylcholine receptor M3 antibody

CHRM3 polyclonal antibody (A01), Lot # 051011JC01 Western Blot analysis of CHRM3 expression in PC-12 ( Cat # L012V1 ). Mouse Serum Hu, Rt E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Muscarinic acetylcholine receptor M3 antibody

Western Blot analysis of CHRM3 expression in transfected 293T cell line (H00001131-T01) by CHRM3 MaxPab polyclonal antibody.

Lane 1: CHRM3 transfected lysate(66.10 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Muscarinic acetylcholine receptor M3 antibody

CHRM3 polyclonal antibody ( Cat # PAB10136 ) staining of formallin fixed paraffin embedded human heart tissue at adilution of 10 µg/ml. Antigen retrieval using a citrate buffer and steam/heat was utilized. Hu
50 µg / €640.00
  Abnova Taiwan Corp.

Muscarinic acetylcholine receptor M3 antibody

Muscarinic acetylcholine receptor M3 Rabbit IgG Aff - Purified Hu E, P
50 µg / €440.00
  Novus Biologicals Inc.

Muscarinic acetylcholine receptor M3 antibody

Immunohistochemistry-Paraffin: Muscarinic Acetylcholine Receptor M3 Antibody [NBP1-87547] Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in Paneth cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M3 Human
10 µg / €540.00
  Abnova Taiwan Corp.

Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

16 Item(s)

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