Muscarinic acetylcholine receptor M4 antibody

Principal name

Muscarinic acetylcholine receptor M4 antibody

Alternative names for Muscarinic acetylcholine receptor M4 antibody

CHRM4

SwissProt ID

P08173 (Human), P08485 (Rat), P17200 (Chick), P30544 (Xenla), P32211 (Mouse), P41986 (Bovin)

Gene ID

1132 (CHRM4), 25111 (Chrm4), 12672

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Hst (Hamster), Por (Porcine), Prim (Primate), Bear

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of Muscarinic acetylcholine receptor M4 antibody

Acetylcholine is a neurotransmitter which activates two different groups of receptors: nicotinic acetylcholine receptors (ChRs) which belong to the superfamily of ligand-gated ion channels and muscarinic acetylcholine receptors (mAChR), belonging to the G-protein coupled receptor (GPCR) superfamily. There are five separate gene products that put together this GPCR subfamily, M1-M5. Generally, M1, M3 and M5 muscarinic receptors are known to activate phospholipase C (PLC) via Gq coupling, while M2 and M4 muscarinic receptors couple to Gi/o, and therefore inhibit adenylate cyclase. This classification is however not clear cut. mAChR can activate adenylate cyclase by coupling to Gs. In addition, M2 and M4 muscarinic receptors, when overexpressed can also activate adenylate cyclase in some systems. Evidence suggests that muscarinic receptors can form homo or heterodimers at that the dimer formed can subsequently affect the downstream sigling pathways. Muscarinic receptors have been shown to regulate voltage-gated Ca2+ channels, mely Cav2.1 as well acid sensing ion channels (ASIC). Generally speaking the actions of muscarinic receptors on ion channels can be either via 2nd messengers or through their direct action on the channels once activated. Furthermore, muscarinic receptors can also promote endocytosis of ion channels (KV1.2 for example) by recruiting tyrosine kises that phosphorylate the channel in order to termite its activity. Other diverse and important functions of muscarinic receptors include cell growth, survival and physiology. Expression of muscarinic receptors is found in neurons in the central nervous system as well as in the peripheral nervous system. In the non-nervous system, these receptors are expressed in the cardiac and smooth muscle, lung, intestine, ovary and urothelium. M4 muscarinic receptor is mostly expressed in the striatum where it colocalizes with D1 dopamine receptors. Malfunction of M4 muscarinic receptor is associated with a number of psychological and neurodegenerative diseases like schizophrenia, Alzheimerâ??s and Parkinsonâ??s diseases.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Muscarinic acetylcholine receptor M4 antibody

  Rabbit polyclonal anti-CHRM4 antibody  
Immunofluorescence analysis of LOVO cells, using CHRM4 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M4 antibody

  Anti-CHRM4 Rabbit Polyclonal Antibody  
Predicted band size: 53kDa. Positive control: NIH/3T3 cell lystate . Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M4 antibody

  Rabbit Polyclonal Anti-M4 Muscarinic Receptor  
Western blot analysis of rat brain membrane (lanes 1 and 2), mouse brain membrane (lane 3 and 5) and SH-SY5Y cell lystae (lanes 4 and 6): 1, 3, 4. Anti-M4 Muscarinic Receptor antibody, (1:200). 2, 5, 6. Anti-M4 Muscarinic Receptor antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M4 (3rd cytopl. dom.) antibody

  Rabbit Polyclonal Anti-CHRM4 Antibody (Cytoplasmic Domain)  
Anti-CHRM4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, GP, Hst, Hu, Ms, Por, Prim, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Muscarinic acetylcholine receptor M4 antibody

Immunofluorescence analysis of LOVO cells, using CHRM4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
50 µg / €230.00
  Assay Biotech

Muscarinic acetylcholine receptor M4 antibody

Immunofluorescence analysis of LOVO cells, using CHRM4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CHRM4 - human gene knockout kit via CRISPR

CHRM4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CHRM4 - human gene knockout kit via CRISPR

CHRM4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CHRM4 - human gene knockout kit via CRISPR

CHRM4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CHRM4 - human gene knockout kit via CRISPR

CHRM4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Chrm4 - mouse gene knockout kit via CRISPR

Chrm4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Chrm4 - mouse gene knockout kit via CRISPR

Chrm4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Chrm4 - mouse gene knockout kit via CRISPR

Chrm4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Chrm4 - mouse gene knockout kit via CRISPR

Chrm4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CHRM4 overexpression lysate

CHRM4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CHRM4 (mGFP-tagged) - Human cholinergic receptor, muscarinic 4 (CHRM4), 200 uL, >10^7 TU/mL

Lenti ORF particles, CHRM4 (mGFP-tagged) - Human cholinergic receptor, muscarinic 4 (CHRM4), 200 uL, >10^7 TU/mL  
200 µl / €1,100.00
  OriGene Technologies, Inc.

Lenti ORF particles, CHRM4 (Myc-DDK tagged) - Human cholinergic receptor, muscarinic 4 (CHRM4) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CHRM4 (Myc-DDK tagged) - Human cholinergic receptor, muscarinic 4 (CHRM4) , 200 uL, >10^7 TU/mL  
200 µl / €980.00
  OriGene Technologies, Inc.

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