MUTYH antibody

Principal name

MUTYH antibody

Alternative names for MUTYH antibody

MYH, MutY homolog, A/G-specific adenine DNA glycosylase

SwissProt ID

Q8R5G2 (Rat), Q99P21 (Mouse), Q9UIF7 (Human)

Gene ID

4595 (MUTYH)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of MUTYH antibody

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (beta3), also known as type 2, contains a distinct 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. These differences cause translation initiation at a downstream start codon and result in a protein (isoform 4) that is shorter than isoform 5. Variants gamma3 and beta3 encode the same isoform, which has been shown to localize to the nucleus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

General / background references:McGoldrick JP et al. Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein. Mol Cell Biol 15:989-96 (1995). PubMed PMID: 7823963
Bonde, P., Gao, D., Chen, L., Miyashita, T., Montgomery, E., Harmon, J. W., and Wei, C. (2007) Duodenal Reflux Leads to Down Regulation of DNA Mismatch Repair Pathway in an Animal Model of Esophageal Cancer, 83, 433-440.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MUTYH antibody

Western blot analysis of MUTYH over-expressed 293 cell line, cotransfected with MUTYH Validated Chimera RNAi ( Cat # H00004595-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with MUTYH monoclonal antibody (M01), clone 4D10 (Cat # H00004595-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control. Mouse IgG1 4D10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MUTYH (C-term) antibody

MUTYH Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
20 µl / €50.00
  SICGEN

MUTYH (C-term) antibody

MUTYH Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
0.6 mg / €300.00
  SICGEN

MUTYH (C-term) antibody

TA302935 (0.1µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MUTYH antibody

Western blot analysis of extracts from HeLa cells and HepG2 cells, using MUTYH antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MUTYH antibody

Predicted band size: 60 kDa . Positive control: Human liver cancer and stomach cancer tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 8%SDS-PAGE Lane1: Human liver cancer tissue lysate Lane2: Human stomach cancer tissue lysate Lysates: 40 ug per lane Primary antibody: 1/1000 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MUTYH antibody

Predicted band size: 60 kDa . Positive control: Hela cell lysate. Recommended dilution: 1/1000-5000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MUTYH antibody

Western blot analysis on HeLa cell lysate using MUTYH Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MUTYH antibody

ELISA: MYH Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

MUTYH (531-546) antibody

Colon: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MUTYH antibody

Immunohistochemistry analysis of MUTYH antibody (Cat.-No AP20553PU-N) in paraffin-embedded human colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MUTYH (Center) antibody

Confocal immunofluorescent analysis of Hela cells using MUTYH antibody Cat.-No. AP52779PU-N, followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). Rabbit Ig Purified Hu, Ms F, ICC/IF, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MUTYH antibody

Western Blot analysis of MUTYH expression in transfected 293T cell line (H00004595-T01) by MUTYH MaxPab polyclonal antibody.

Lane 1: MUTYH transfected lysate(59.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

MUTYH antibody

MUTYH Mouse IgG1 1C8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MUTYH antibody

Western blot analysis of MUTYH in 20 µgs of HeLa cell lysate. Using MUTYH polyclonal antibody ( Cat # PAB0208 ) at 2 µg/ml. Rabbit Hu WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

MUTYH antibody

MUTYH polyclonal antibody ( Cat # PAB6606 ) ( 0.1 µg/ml ) staining of human bone marrow lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

MUTYH antibody

Immunofluorescence analysis of A549 cells, using MUTYH Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

MUTYH antibody

Immunofluorescence analysis of A549 cells, using MUTYH Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

MUTYH antibody

Immunohistochemical analysis of MUTYH staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

MUTYH antibody

Immunohistochemical analysis of MUTYH staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

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