MXI1 antibody

Principal name

MXI1 antibody

Alternative names for MXI1 antibody

MAX-interacting protein 1, bHLHc11, Max interactor 1, Class C basic helix-loop-helix protein 11

SwissProt ID

O09015 (Rat), P50539 (Human), P50539-3, P50540 (Mouse)

Gene ID

4601 (MXI1), 17859 (Mxi1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of MXI1 antibody

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors. Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.

General readings

Lofstedt, T. et al., Exp. Cell Res. 315(11): 1924-1936 (2009)
Baranzini, S.E. et al., Hum. Mol. Genet. 18(4): 767-778 (2009)
Tsao, C.C. et al., Cancer Biol. Ther. 7(10): 1619-1627 (2008)
Suo, X.H. et al., Zhonghua Xue Ye Xue Za Zhi 28(11): 745-749 (2007)
Dugast-Darzacq, C. et al., FEBS J. 274(17): 4643-4653 (2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MXI1 antibody

  Rabbit Polyclonal anti-MXI1 antibody  
WB Suggested Anti-MXI1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: SH-SYSY cell lysateMXI1 is supported by BioGPS gene expression data to be expressed in SHSY5Y Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

MXI1 antibody

  Rabbit Polyclonal anti-MXI1 antibody  
WB Suggested Anti-MXI1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human brain Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

MXI1 antibody

  Rabbit Polyclonal Anti-Mxi1 Antibody  
Host: Rabbit; Target Name: Mxi1; Sample Tissue: Mouse Muscle lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MXI1 (Center) antibody

Western blot analysis in mouse heart tissue lysates (35ug/lane) using MXI1 antibody Cat.-No. AP52782PU-N. This demonstrates this antibody detected the MXI1 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MXI1 - human gene knockout kit via CRISPR

MXI1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MXI1 - human gene knockout kit via CRISPR

MXI1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MXI1 - human gene knockout kit via CRISPR

MXI1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MXI1 - human gene knockout kit via CRISPR

MXI1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mxi1 - mouse gene knockout kit via CRISPR

Mxi1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mxi1 - mouse gene knockout kit via CRISPR

Mxi1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mxi1 - mouse gene knockout kit via CRISPR

Mxi1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mxi1 - mouse gene knockout kit via CRISPR

Mxi1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MXI1 overexpression lysate

MXI1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

MXI1 overexpression lysate

MXI1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MXI1 (mGFP-tagged)-Human MAX interactor 1 (MXI1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, MXI1 (mGFP-tagged)-Human MAX interactor 1 (MXI1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, MXI1 (mGFP-tagged) - Human MAX interactor 1 (MXI1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, MXI1 (mGFP-tagged) - Human MAX interactor 1 (MXI1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, MXI1 (Myc-DDK-tagged)-Human MAX interactor 1 (MXI1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, MXI1 (Myc-DDK-tagged)-Human MAX interactor 1 (MXI1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, MXI1 (Myc-DDK tagged) - Human MAX interactor 1 (MXI1), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, MXI1 (Myc-DDK tagged) - Human MAX interactor 1 (MXI1), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Mxi1 (GFP-tagged) - Mouse Max interacting protein 1 (Mxi1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Mxi1 (GFP-tagged) - Mouse Max interacting protein 1 (Mxi1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Mxi1 (GFP-tagged) - Mouse Max interacting protein 1 (Mxi1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Mxi1 (GFP-tagged) - Mouse Max interacting protein 1 (Mxi1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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