MXI1 antibody

Principal name

MXI1 antibody

Alternative names for MXI1 antibody

MAX-interacting protein 1, bHLHc11, Max interactor 1, Class C basic helix-loop-helix protein 11

SwissProt ID

O09015 (Rat), P50539 (Human), P50539-3, P50540 (Mouse)

Gene ID

4601 (MXI1), 17859 (Mxi1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of MXI1 antibody

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors. Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.

General readings

Lofstedt, T. et al., Exp. Cell Res. 315(11): 1924-1936 (2009)
Baranzini, S.E. et al., Hum. Mol. Genet. 18(4): 767-778 (2009)
Tsao, C.C. et al., Cancer Biol. Ther. 7(10): 1619-1627 (2008)
Suo, X.H. et al., Zhonghua Xue Ye Xue Za Zhi 28(11): 745-749 (2007)
Dugast-Darzacq, C. et al., FEBS J. 274(17): 4643-4653 (2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MXI1 antibody

  Rabbit Polyclonal anti-MXI1 antibody  
WB Suggested Anti-MXI1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: SH-SYSY cell lysateMXI1 is supported by BioGPS gene expression data to be expressed in SHSY5Y Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

MXI1 antibody

  Rabbit Polyclonal anti-MXI1 antibody  
WB Suggested Anti-MXI1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human brain Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

MXI1 antibody

  Rabbit Polyclonal Anti-Mxi1 Antibody  
Host: Rabbit; Target Name: Mxi1; Sample Tissue: Mouse Muscle lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MXI1 (Center) antibody

Western blot analysis in mouse heart tissue lysates (35ug/lane) using MXI1 antibody Cat.-No. AP52782PU-N. This demonstrates this antibody detected the MXI1 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MXI1 antibody

Western Blot analysis of MXI1 expression in transfected 293T cell line (H00004601-T03) by MXI1 MaxPab polyclonal antibody.

Lane 1: MXI1 transfected lysate(20.13 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

MXI1 antibody

MXI1 MaxPab polyclonal antibody. Western Blot analysis of MXI1 expression in human placenta. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

MXI1 antibody

Western Blot analysis of MXI1 expression in transfected 293T cell line by MXI1 monoclonal antibody (M08), clone 1F3.

Lane 1: MXI1 transfected lysate(26.1 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 1F3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MXI1 antibody

MXI1 Mouse IgG2a 1B10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MXI1 antibody

Human SH-SYSY; WB Suggested Anti-MXI1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: SH-SYSY cell lysate. MXI1 is supported by BioGPS gene expression data to be expressed in SHSY5Y.; MXI1 antibody - middle region (ARP31402_P050) in Human SH-SYSY cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

MXI1 - human gene knockout kit via CRISPR

MXI1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MXI1 - human gene knockout kit via CRISPR

MXI1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MXI1 - human gene knockout kit via CRISPR

MXI1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MXI1 - human gene knockout kit via CRISPR

MXI1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mxi1 - mouse gene knockout kit via CRISPR

Mxi1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mxi1 - mouse gene knockout kit via CRISPR

Mxi1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mxi1 - mouse gene knockout kit via CRISPR

Mxi1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mxi1 - mouse gene knockout kit via CRISPR

Mxi1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MXI1

MXI1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

MXI1

MXI1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

MXI1

MXI1 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

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