Alternative names for MYCBP2 antibody
Myc-binding protein 2, KIAA0916, PAM, Probable E3 ubiquitin-protein ligase MYCBP2, Protein associated with Myc, Pam/highwire/rpm-1 protein
Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of MYCBP2 antibody
In addition to its possible functions as a facilitator of Myc activated transcription, PAM (protein associated with Myc) has also been shown to play a role in mTOR signaling. PAM functions as an E3 ubiquitin ligase for tuberin (TSC2), a negative regulator of the mTOR pathway. Additionally PAM has been shown to function as a guanosine exchange factor (GEF) for Rheb and to facilitate sphingosine-1-phosphate signaling in the mTOR pathway. Alternative names for PAM include Myc-binding protein 2, MYCBP2, Pam/highwire/rpm-1 protein, and KIAA0916.