MYD88 antibody

Principal name

MYD88 antibody

Alternative names for MYD88 antibody

Myeloid differentiation primary response protein MyD88

SwissProt ID

P22366 (Mouse), Q99836 (Human)

Gene ID

4615 (MYD88)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Chimp (Chimpanzee), Rt (Rat), Bov (Bovine), Chk (Chicken), Por (Porcine), Mky (Monkey), Sh (Sheep)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Dot blot (Dot), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MYD88 antibody

The mammalian host defense system is essentially regulated by Toll-like receptor (TLR) family. Toll-like receptors (TLRs) play an important role in recognition of microbial components and induction of innate immunity. At least 10 TLRs have been identified and cloned in mammalian cells which recognize molecular products/signals from all the major classes of pathogens. The Toll signaling to NF-Kb starts form conserved Toll-IL-1-resistance (TIR) domain, which mediated the coupling of TIR adaptor molecules (MyD88, Mal, TICAM and TRAM). Most of the TLRs are dependent on the expression of adapter molecules MyD88 for all their function, the TL3 and TLR 4 are unique in their ability to mediate both MyD88-dependent and independent reposes (1). The MyD88 independent pathway involves induction of a DC maturation and induction of type 1 interferon (IFN-B).
Murine MyD88, an RNA with homology both to the interleukin-1 receptor signaling domain and to ’death-domains’, is rapidly up-regulated during differentiation of the myeloleukemic cell line M1. The murine MyD88 is 53 amino acids larger than human MyD88 and maps to chromosome 3p21.3-p22. The over expression of death region in MyD88 lead to transcriptional activation of IL-8 promoter. The microbial components trigger the activation of two downstream signaling pathways of TLRs; MyD88- and/or TRIF-dependent pathways leading to activation of NF-kappaB. The MyD88 transduces a core set of Toll-like receptor (TLR)-induced signals, microbial-induced host responses are divided broadly into the MyD88-dependent and MyD88-independent pathways. The specific pathogen induced early host responses are generally mediated by MyD88 dependent pathways. Inhaled endotoxins induce an acute inflammatory response in the airways mediated through Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88). The endotoxin-induced acute bronchoconstriction, vascular damage resulting in protein leak, Th1 cytokine and chemokine secretion and neutrophil recruitment in the airways are abrogated in mice deficient for either TIRAP or MyD88, but not in TRIF deficient mice (2). The bronchoconstriction and acute inflammatory lung pathology mediated by TLR-4 to inhaled endotoxins critically dependent on the expression and co-operative role of adaptor proteins, TIRAP and MyD88 (3). The MyD88 mediated post-TLR signaling is also involved in a number of allergents and endotoxins.

General readings

Wiens M, Korzhev M, Krasko A, Thakur N, Perovi-Ottstadt S, Breter H, Ushijima H, Diehl-Seifert B, Müller I, Müller WEG (2005) Innate immune defense of the sponge Suberites domuncula against bacteria involves a MyD88-dependent signalling pathway: Induction of a perforin-like molecule. J. Biol. Chem. 280: 27949-27959.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MYD88 antibody

Anti-MYD88 mouse monoclonal antibody (TA502104) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MYD88(RC202253). Mouse IgG2a OTI1B4 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MYD88 antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-MYD88 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502117) Mouse IgG2a OTI2B2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MYD88 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-MYD88 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502116) Mouse IgG2a OTI1A10 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MYD88 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-MYD88 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502118) Mouse IgG1 OTI1B8 Purified Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

MYD88 antibody

TA302999 staining (0.01µg/ml) of MOLT4 lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Can, Chimp, Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MYD88 antibody

Western blot analysis of MyD88 in Jurkat whole cell lysate with MyD88 antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MYD88 (C-term) antibody

Western blot analysis of MyD88 in Jurkat whole cell lysate with MyD88 antibody at 1:500 dilution. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MYD88 (176-280) antibody

Western blot analysis of MyD88 in EL4 whole cell lysate with MyD88 antibody at 2 ug/mL. Mouse IgG 2E9C2 Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MYD88 antibody

Predicted band size: 33 kDa . Positive control: K562 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MYD88 antibody

Western blot analysis of extracts of various cell lines, using MYD88 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MYD88 (C-term) antibody

Raji whole cell lysates were resolved by electrophoresis, transferred to nitrocellulose and probed with a rabbit anti-MYD88 polyclonal antibody (Poly6489). Proteins were visualized using donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluniscence system. Rabbit IgG Aff - Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MYD88 antibody

Western Blot: MyD88 Antibody [TA336449] - Analysis of MyD88 in human spleen cell lysate using 0.5 ug/ml of TA336449. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MYD88 antibody

Western Blot: MyD88 Antibody [TA337031] - Analysis of MyD88 using MyD88 antibody. Human Ramos cell lysate probed using MyD88 antibody at 4 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. Rabbit Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MYD88 antibody

Western Blot: MyD88 Antibody (4D6) [TA337167] - Analysis of MyD88 in A) human ovary, B) human prostate and Jurkat cell lysate in the C) absence and D) presence of immunizing peptide using this antibody. Goat anti-mouse Ig HRP secondary antibody and PicoTe Mouse 4D6 Purified Hu F, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MYD88 antibody

a: SDS-Page of protein extract of immune stimulated Suberites domuncula. b: Size-seperated proteins were transferred to membranes and reacted with antibody. M: Molecular mass marker proteins Rabbit Serum C, E, WB
0.1 ml / €510.00
  Acris Antibodies GmbH

MYD88 antibody

a: SDS-Page of protein extract of immune stimulated Suberites domuncula. b: Size-seperated proteins were transferred to membranes and reacted with antibody. M: Molecular mass marker proteins Rabbit Serum C, E, WB
20 µl / €150.00
  Acris Antibodies GmbH

MYD88 antibody

Spleen: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MYD88 (233-248) antibody

Skin: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MYD88 Control Peptide

MYD88
0.25 mg / €250.00
  Acris Antibodies GmbH

MYD88 antibody

MYD88 Rabbit Aff - Purified Hu, Ms, Rt C, Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

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