Myelin Basic Protein antibody

Principal name

Myelin Basic Protein antibody

Alternative names for Myelin Basic Protein antibody

MBP, Myelin membrane encephalitogenic protein

SwissProt ID

P02686 (Human), P02687 (Bovin), P02688 (Rat), P04370 (Mouse), P15720 (Chick), P81558 (Pig)

Gene ID

4155 (MBP), 24547 (Mbp), 17196

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine), Rb (Rabbit), GP (Guinea Pig), Sh (Sheep), Mam (Mammalia), Mky (Monkey), Gt (Goat), Chk (Chicken), var., Eq (Equine)

Available hosts

Mouse, Rabbit, Chicken, Rat, Sheep

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P), Immunoprecipitation (IP), Radioimmunoassay (R), Flow Cytometry (F), Dot blot (Dot)

Selected product citations ‐ of AM33492SU-N

Unconjugated antibody is cited in:
1. Hantel C, Lewrick F, Schneider S, Zwermann O, Perren A, Reincke M, et al. Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency. J Clin Endocrinol Metab. 2010 Feb;95(2):943-52. doi: 10.1210/jc.2009-1980. Epub 2009 Dec 1. PubMed PMID: 19952224.

Background of Myelin Basic Protein antibody

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelition of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelition, maybe as components of transcriptiol complexes, and may also be involved in sigling pathways in T-cells and neural cells. Differential splicing events combined with optiol post-translatiol modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. MBP induces T-cell proliferation.The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additiol exons located upstream of the classic MBP exons. Altertive splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-termil Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

General readings

1. Su WC, Chou HY, Chang CJ, Lee YM, Chen WH, Huang KH, et al. Differential activation of a C/EBP beta isoform by a novel redox switch may confer the lipopolysaccharide-inducible expression of interleukin-6 gene. J Biol Chem. 2003 Dec 19;278(51):51150-8. Epub 2003 Oct 6. PubMed PMID: 14530280.
2. Chang CJ, Chen TT, Lei HY, Chen DS, Lee SC. Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family. Mol Cell Biol. 1990 Dec;10(12):6642-53. PubMed PMID: 1701020.
3. Eaton EM, Hanlon M, Bundy L, Sealy L. Characterization of C/EBPbeta isoforms in normal versus neoplastic mammary epithelial cells. J Cell Physiol. 2001 Oct;189(1):91-105. PubMed PMID: 11573208.
4. Piwien-Pilipuk G, MacDougald O, Schwartz J. Dual regulation of phosphorylation and dephosphorylation of C/EBPbeta modulate its transcriptional activation and DNA binding in response to growth hormone. J Biol Chem. 2002 Nov 15;277(46):44557-65. Epub 2002 Sep 3. PubMed PMID: 12213825.
5. Hattori T, Ohoka N, Inoue Y, Hayashi H, Onozaki K. C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer. Oncogene. 2003 Mar 6;22(9):1273-80. PubMed PMID: 12618752.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Myelin Basic Protein antibody

Immunofluorescence image of rat brain (8 um sagittal section) stained with the SMI 94 antibody (red), GFAP (green) and Hoechst (blue). Photo courtesy of Molecular Expressions. Mouse IgG1 SMI 94 Ascites Mam C, ICC/IF, P, WB
0.1 ml / €620.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

WB Suggested Anti-MBP Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt IP, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Western Blot: Myelin Basic Protein Antibody (2H9) [TA336919] - Western blot analysis using Myelin Basic Protein mAb against HEK293 (1) and Myelin Basic Protein-hIgGFc transfected HEK293 (2) cell lysate. Mouse IgG1 2H9 Purified Hu E, F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Immunohistochemical analysis of paraffin-embedded brain tissues using MBP mouse mAb with DAB staining. Mouse IgG1 2H9 Ascites Hu E, F, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

Human brain; . Sample Type :. Human brain stem cells. Primary Antibody Dilution :. 1:500. Secondary Antibody :. Goat anti-rabbit Alexa-Fluor 594. Secondary Antibody Dilution :. 1:1000. Color/Signal Descriptions :. MBP: Red DAPI:Blue. Gene Name :. MBP. Submitted by :. Dr. Yuzhi Chen, University of Arkansas for Medical Science; MBP antibody - middle region (ARP56224_P050) in Human brain cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Myelin Basic Protein antibody

Western blot of rat cortex homogenate showing specific immunolabeling of the ~ 18 & 22k MBP protein. Chicken Ig Ig Fraction Bov, Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Anti-Myelin Basic Protein antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Mouse IgG1 V/h5 Purified GP, Hu, Rb, Sh P
50 µg / €345.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Predicted band size: 33 kDa . Positive control: Rat brain, Mouse brain and Rat hippocampus tissue lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1: Rat brain tissue lysate Lane2: Mouse brain tissue lysate Lane3: Rat hippocampus tissue lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Western blot analysis of extracts of various cell lines, using MBP antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Immunohistochemistry staining of Paraffin Brain tissue by Myelin Basic Protein antibody (dilution: 1:50 - 1:200; visualization of staining: Cytoplasmic) Rabbit Purified Hu P
1 ml / €480.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

WB Suggested Anti-MBP Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Western Blot: Myelin Basic Protein Antibody [TA336547] - WB analysis of Myelin Basic Protein (MBP) in 10ug of normal brain lysate with antibody TA336547 at 1:500 dilution. Rabbit Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Western blot analysis of extract from Rat brain, Mouse brain and Rat hippocampus Tissue using MBP Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Myelin Basic Protein Mouse IgG 7D2 Bov, Hu, Ms, Rt ICC/IF, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

Myelin Basic Protein Mouse IgG 7G7 Hu, Ms, Rt ICC/IF, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

Myelin Basic Protein Rabbit IgG Purified Hu, Rt E, WB
1 ml / €320.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

Myelin Basic Protein Rabbit IgG Purified Hu C, ICC/IF, P
1 ml / €320.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

Myelin Basic Protein Rabbit IgG Purified Hu C, ICC/IF, P
0.5 ml / €250.00
  Acris Antibodies GmbH

Myelin Basic Protein pTyr203 antibody

Dot blot analysis of anti-Phospho-MBP pTyr203 Antibody (Cat.#AP12968PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

Immunofluorescence. Rat mixed neuron/glial cultures stained with Chicken Myelin Basic Protein antibody (Green). Blue is a DNA stain. Note that the MBP antibody stains an oligodendrocyte and some membrane shed from this cell. Other cells in the field include neurons, astrocytes, microglia and fibroblasts, all of which are completely negative. specifically, and that the staining is concentrated in the cell bodies. Chicken Ig Aff - Purified ICC/IF, WB
0.1 ml / €360.00
  Acris Antibodies GmbH

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