Myelin Basic Protein antibody

Principal name

Myelin Basic Protein antibody

Alternative names for Myelin Basic Protein antibody

MBP, Myelin membrane encephalitogenic protein

SwissProt ID

P02686 (Human), P02687 (Bovin), P02688 (Rat), P04370 (Mouse), P15720 (Chick), P81558 (Pig)

Gene ID

4155 (MBP), 17196 (Mbp), 24547

Available reactivities

Hu (Human), Bov (Bovine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep), Mam (Mammalia), Chk (Chicken), Rt (Rat), Ms (Mouse), Gt (Goat), Can (Canine), Eq (Equine)

Available hosts

Mouse, Rat, Rabbit, Sheep, Chicken

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Radioimmunoassay (R), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Flow Cytometry (F), Immunoprecipitation (IP)

Background of Myelin Basic Protein antibody

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelition of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelition, maybe as components of transcriptiol complexes, and may also be involved in sigling pathways in T-cells and neural cells. Differential splicing events combined with optiol post-translatiol modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. MBP induces T-cell proliferation.The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additiol exons located upstream of the classic MBP exons. Altertive splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-termil Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

General readings

Nye S.H., et al (1995). Mol. Immunol. 32:1131-1141Pribyl T.M., et al (1993). Proc. Natl. Acad. Sci. U.S.A. 90:10695-10699

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Myelin Basic Protein antibody

  Rabbit Polyclonal Anti-MBP Antibody  
WB Suggested Anti-MBP Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt IP, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

  Mouse Monoclonal MBP Antibody (2H9)  
Western Blot: Myelin Basic Protein Antibody (2H9) [TA336919] - Western blot analysis using Myelin Basic Protein mAb against HEK293 (1) and Myelin Basic Protein-hIgGFc transfected HEK293 (2) cell lysate. Mouse IgG1 2H9 Purified Hu E, F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Immunohistochemical analysis of paraffin-embedded brain tissues using MBP mouse mAb with DAB staining. Mouse IgG1 2H9 Ascites Hu E, F, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

  Chicken Anti-Myelin Basic Protein (MBP) Antibody  
Western blot of rat cortex homogenate showing specific immunolabeling of the ~ 18 & 22k MBP protein. Chicken Ig Ig Fraction Bov, Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

  Myelin Basic Protein / MBP Mouse Monoclonal (N-Terminus) (V/h5) Antibody  
Anti-Myelin Basic Protein antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Mouse IgG1 V/h5 Purified GP, Hu, Rb, Sh P
50 µg / €400.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

  Anti-MBP Rabbit Polyclonal Antibody  
Predicted band size: 33 kDa . Positive control: Rat brain, Mouse brain and Rat hippocampus tissue lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1: Rat brain tissue lysate Lane2: Mouse brain tissue lysate Lane3: Rat hippocampus tissue lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

  MBP Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using MBP antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

  Rabbit Polyclonal Myelin Basic Protein Antibody  
Immunohistochemistry staining of Paraffin Brain tissue by Myelin Basic Protein antibody (dilution: 1:50 - 1:200; visualization of staining: Cytoplasmic) Rabbit Purified Hu P
1 ml / €1,000.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

  Rabbit Polyclonal Anti-MBP Antibody  
WB Suggested Anti-MBP Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

  Rabbit Polyclonal MBP Antibody  
Western Blot: Myelin Basic Protein Antibody [TA336547] - WB analysis of Myelin Basic Protein (MBP) in 10ug of normal brain lysate with antibody TA336547 at 1:500 dilution. Rabbit Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

  Rabbit Polyclonal Anti-MBP(myelin basic protein) Antibody  
Western blot analysis of extract from Rat brain, Mouse brain and Rat hippocampus Tissue using MBP Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Myelin Basic Protein antibody

Myelin Basic Protein Rabbit IgG Purified Hu, Rt E, WB
1 ml / €320.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

Myelin Basic Protein Rabbit IgG Purified Hu C, ICC/IF, P
1 ml / €320.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

Myelin Basic Protein Rabbit IgG Purified Hu C, ICC/IF, P
0.5 ml / €250.00
  Acris Antibodies GmbH

Myelin Basic Protein pTyr203 antibody

Dot blot analysis of anti-Phospho-MBP pTyr203 Antibody (Cat.#AP12968PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

Myelin Basic Protein (C-term) antibody

Immunohistochemical analysis of paraffin embedded Human tissue sections (liver) using MBP antibody Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Myelin Basic Protein antibody

A tissue section through an adult Mouse brain showing MBP (red staining) of white matter tracts adjacent to the hippocampal formation. Green staining is autofluorescence from Green Fluorescent Protein (GFP) expressed in this transgenic Mouse. Chicken Ig Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €500.00
  Acris Antibodies GmbH

Myelin Basic Protein (N-term) antibody

Immunohistochemistry : BM017 BMP antibody staining of Formalin-Fixed Paraffin-Embedded Human Brain, Cortex at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 V/h5 Purified Bov, GP, Hu, Por, Rb, Sh E, P, R
0.2 mg / €450.00
  Acris Antibodies GmbH

Myelin Basic Protein (36-50) antibody

Myelin Basic Protein Rat IgG 14 Supernatant Hu, Mam C, E, WB
2 ml / €480.00
  Acris Antibodies GmbH

Myelin Basic Protein (67-74) antibody

Myelin Basic Protein Mouse IgG1 26 Supernatant Hu, Mam C, WB
2 ml / €490.00
  Acris Antibodies GmbH

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