Myeloperoxidase antibody
Principal name
Myeloperoxidase antibody
Alternative names for Myeloperoxidase antibody
MPO
Ncbi ID
9606, NP_000241, NM_000250, NP_000241.1, 10090, NP_034954.2, NM_010824
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of Myeloperoxidase antibody
Myeloperoxidase (MPO) is a functionally important component of the normal human neutrophil azurophil granule of polymorphonuclear leukocytes, host defense system. MPO is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. The inflammatory component of allergic reactions can be measured by eosinophil cationic protein (ECP, specific for eosinophils) and myeloperoxidase (MPO, specific for neutrophils) measurement (1). Neutrophils, especially in acute infection or the myeloid leukemias, may shed platelet-sized particles that can readily be distinguished from true platelets because they contain neutrophil myeloperoxidase, an enzyme that is not inhibited by glutraldehyde. Traditionally Myeloperoxidase was considered as a serological marker for ulomatosis (Churg-Strauss syndrome), the main target of anti-neutrophil cytoplasm antibodies (ANCA), Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that MPO participates in the initiation and progression of cardiovascular disease. It possesses potent pro-inflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is uncertain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic grander consideration as one of the most promising cardiac markers.
Human myeloperoxidase, a 745 aa protein is produced by a gene composed of 12 exons and 11 introns.The sequence was found to contain an open reading frame, 2,235 nucleotides coding for a protein of 745 amino acids with a calculated Mr of 83,868. The heavy chain of myeloperoxidase, consisting of 467 amino acids, was located on the COOH terminus half of the protein. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 - 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW 150 kDa and theoretical pI 9.2, each of which is associated with a heme-like prosthetic group. The heme environment, defined by X-ray crystallographic analyses of MPO appears to be highly conserved in four mammalian peroxidases (lactoperoxidase, thyroid, esinophil and Myeloperoxidase). MPO when heated under non-reducing, denaturing conditions, MPO is cleaved to produced 22 and a 38kDa proteins, these two species are produced via a novel autolytic cleavage at Meth409 and Pro410 (2).
General readings
Banerjee, M. et al., Toxicol. Appl. Pharmacol. 249(1): 47-54 (2010)
Shimada, M. et al., Hum. Genet. 128(4): 433-441 (2010)
Nahon, P. et al., Antioxid. Redox Signal. 15(1): 31-38 (2010)
Wang, Y. et al., J. Huazhong Univ. Sci. Technol. Med. Sci. 30(4): 437-442 (2010)
Hua, F. et al., Zhongguo Fei Ai Za Zhi 13(2): 122-127 (2010)


















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Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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SM1475R | Myeloperoxidase antibody |
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Mouse | IgG1 | 2C7 | PE | Hu | F |
100 Tests /
€490.00
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Acris Antibodies GmbH | |||||||
Published recently! |
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AP32134PU-N | Myeloperoxidase antibody |
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Goat | Aff - Purified | Hu | WB |
0.1 mg /
€350.00
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Acris Antibodies GmbH | |||||||
Acris recommends this product for Western blotting. |
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TA318973 | Myeloperoxidase antibody |
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Rabbit polyclonal anti-Myeloperoxidase (MPO) antibody | |||||||
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Rabbit | Purified | Hu, Ms | WB |
0.1 mg /
€353.00
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OriGene Technologies, Inc. | |||||||
TA319305 | Myeloperoxidase antibody |
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Rabbit polyclonal Myeloperoxidase antibody | |||||||
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Rabbit | IgG | Serum | Hu | E, WB |
2 ml /
€1,341.00
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OriGene Technologies, Inc. | |||||||
TA327707 | Myeloperoxidase antibody |
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Rabbit Polyclonal Myeloperoxidase Antibody | |||||||
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Rabbit | Purified | Hu | P |
1 ml /
€500.00
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OriGene Technologies, Inc. | |||||||
TA343091 | Myeloperoxidase antibody |
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Rabbit Polyclonal Anti-MPO Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt | WB |
50 µg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA349402 | Myeloperoxidase antibody |
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Rabbit Polyclonal Anti-MPO Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms | E, P |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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AM05455PU-N | Myeloperoxidase antibody |
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Mouse | IgG2b | 4A4 | Purified | Hu | WB |
0.2 mg /
€370.00
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Acris Antibodies GmbH | |||||||
AM05456PU-N | Myeloperoxidase antibody |
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Mouse | IgG2a | 2A11 | Purified | Hu |
0.2 mg /
€380.00
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Acris Antibodies GmbH | |||||||
AM08220SU-N | Myeloperoxidase antibody |
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Mouse | IgG2b | 59A5 | Supernatant | Hu | P |
1 ml /
€460.00
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Acris Antibodies GmbH | |||||||
AM08220SU-S | Myeloperoxidase antibody |
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Mouse | IgG2b | 59A5 | Supernatant | Hu | P |
0.5 ml /
€310.00
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Acris Antibodies GmbH | |||||||
AM20446SU-N | Myeloperoxidase (1-193) antibody |
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Mouse | IgG1 | 9B12G7 | Ascites | Hu | E, P, WB |
50 µl /
€380.00
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Acris Antibodies GmbH | |||||||
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AM26163BT-N | Myeloperoxidase antibody |
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Mouse | IgG1 | 2D4 | Biotin | Ms, Rt | C, E, ICC/IF |
50 µg /
€360.00
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Acris Antibodies GmbH | |||||||
AM26163FC-N | Myeloperoxidase antibody |
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Mouse | IgG1 | 2D4 | FITC | Ms, Rt | C, E, ICC/IF |
0.1 mg /
€560.00
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Acris Antibodies GmbH | |||||||
AM26163PU-N | Myeloperoxidase antibody |
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Mouse | IgG1 | 2D4 | Purified | Ms, Rt | C, E, ICC/IF |
0.1 mg /
€480.00
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Acris Antibodies GmbH | |||||||
AM26227BT-N | Myeloperoxidase antibody |
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Mouse | IgG1 | 266-6K1 | Biotin | Hu | E, WB |
50 µg /
€280.00
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Acris Antibodies GmbH | |||||||
AM26227PU-N | Myeloperoxidase antibody |
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Mouse | IgG1 | 266-6K1 | Purified | Hu | E, WB |
0.1 mg /
€350.00
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Acris Antibodies GmbH | |||||||
AM26325BT-N | Myeloperoxidase antibody |
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Mouse | IgG1 | 8F4 | Biotin | Ms, Rt | C, E |
50 µg /
€340.00
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Acris Antibodies GmbH | |||||||
AM26325FC-N | Myeloperoxidase antibody |
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Mouse | IgG1 | 8F4 | FITC | Ms, Rt | C, E |
0.1 mg /
€530.00
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Acris Antibodies GmbH | |||||||
AM26325PU-N | Myeloperoxidase antibody |
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Mouse | IgG1 | 8F4 | Purified | Ms, Rt | C, E |
0.1 mg /
€480.00
|
Acris Antibodies GmbH |