Myeloperoxidase antibody

Principal name

Myeloperoxidase antibody

Alternative names for Myeloperoxidase antibody

MPO

SwissProt ID

P05164 (Human), P11247 (Mouse)

Gene ID

4353 (MPO), 17523 (Mpo)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Rb (Rabbit), Bac (Bacteria), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Gt (Goat), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (capture) (E(capture)), ELISA (detection) (E(detection))

Background of Myeloperoxidase antibody

Myeloperoxidase (MPO) is a functionally important component of the normal human neutrophil azurophil granule of polymorphonuclear leukocytes, host defense system. MPO is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. The inflammatory component of allergic reactions can be measured by eosinophil cationic protein (ECP, specific for eosinophils) and myeloperoxidase (MPO, specific for neutrophils) measurement (1). Neutrophils, especially in acute infection or the myeloid leukemias, may shed platelet-sized particles that can readily be distinguished from true platelets because they contain neutrophil myeloperoxidase, an enzyme that is not inhibited by glutraldehyde. Traditionally Myeloperoxidase was considered as a serological marker for ulomatosis (Churg-Strauss syndrome), the main target of anti-neutrophil cytoplasm antibodies (ANCA), Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that MPO participates in the initiation and progression of cardiovascular disease. It possesses potent pro-inflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is uncertain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic grander consideration as one of the most promising cardiac markers.
Human myeloperoxidase, a 745 aa protein is produced by a gene composed of 12 exons and 11 introns.The sequence was found to contain an open reading frame, 2,235 nucleotides coding for a protein of 745 amino acids with a calculated Mr of 83,868. The heavy chain of myeloperoxidase, consisting of 467 amino acids, was located on the COOH terminus half of the protein. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 - 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW 150 kDa and theoretical pI 9.2, each of which is associated with a heme-like prosthetic group. The heme environment, defined by X-ray crystallographic analyses of MPO appears to be highly conserved in four mammalian peroxidases (lactoperoxidase, thyroid, esinophil and Myeloperoxidase). MPO when heated under non-reducing, denaturing conditions, MPO is cleaved to produced 22 and a 38kDa proteins, these two species are produced via a novel autolytic cleavage at Meth409 and Pro410 (2).

General readings

Banerjee, M. et al., Toxicol. Appl. Pharmacol. 249(1): 47-54 (2010)
Shimada, M. et al., Hum. Genet. 128(4): 433-441 (2010)
Nahon, P. et al., Antioxid. Redox Signal. 15(1): 31-38 (2010)
Wang, Y. et al., J. Huazhong Univ. Sci. Technol. Med. Sci. 30(4): 437-442 (2010)
Hua, F. et al., Zhongguo Fei Ai Za Zhi 13(2): 122-127 (2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Myeloperoxidase antibody

Staining of Human bone marrow: Formalin fixed, paraffin processed tissue with Mouse anti Human Myeloperoxidase (Cat.-No. SM1475P/PT). Mouse IgG1 2C7 Purified Hu C, E, F, P, WB
0.2 mg / €520.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Staining of Human bone marrow: Formalin fixed, paraffin processed tissue with Mouse anti Human Myeloperoxidase (Cat.-No. SM1475P/PT). Mouse IgG1 2C7 Purified Hu C, E, F, P, WB
20 µg / €240.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Myeloperoxidase Mouse IgG1 2C7 PE Hu F
100 Tests / €480.00
  Acris Antibodies GmbH

Myeloperoxidase (C-term) antibody

AM09109PU Myeloperoxidase antibody staining of Human Tonsil. Rabbit IgG SP72 Purified Hu P
0.5 ml / €520.00
  Acris Antibodies GmbH

Myeloperoxidase (C-term) antibody

AM09109PU Myeloperoxidase antibody staining of Human Tonsil. Rabbit IgG SP72 Purified Hu P
1 ml / €750.00
  Acris Antibodies GmbH

Myeloperoxidase (C-term) antibody

AM09109PU Myeloperoxidase antibody staining of Human Tonsil. Rabbit IgG SP72 Purified Hu P
0.1 ml / €290.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Human lymph node stained with anti-myeloperoxidase antibody. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Human lymph node stained with anti-myeloperoxidase antibody. Rabbit Purified Hu P
1 ml / €490.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Human lymph node stained with anti-myeloperoxidase antibody. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Staining of Human Peripheral Blood Lymphocyte lysate using Myeloperoxidase antibody Cat.-No AP32134PU-N at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Western blot analysis of MPO with Jurkat (Lane 1, 2) and 3T3 (Lane 3) cell lysate. Rabbit Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Myeloperoxidase antibody

Anti-Myeloperoxidase [Human Leukocytes] detects multiple MPO subunits and chain combinations by WB.  Polyclonal rabbit-anti-Myeloperoxidase was used at a 1:5000 dilution to detect 1.0 ug of human myeloperoxidase. Rabbit IgG Serum Hu E, WB
2 ml / €900.00
  OriGene Technologies, Inc.

Myeloperoxidase antibody

Immunohistochemistry staining of Paraffin Bone marrow tissue by Myeloperoxidase antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic) Rabbit Purified Hu P
1 ml / €490.00
  OriGene Technologies, Inc.

Myeloperoxidase antibody

WB Suggested Anti-MPO Antibody; Titration: 1.0 ug/ml; Positive Control: 293T Whole CellMPO is supported by BioGPS gene expression data to be expressed in HEK293T Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Myeloperoxidase antibody

Myeloperoxidase Mouse IgG2b 4A4 Purified Hu WB
0.2 mg / €360.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Myeloperoxidase Mouse IgG2a 2A11 Purified Hu
0.2 mg / €370.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Myeloperoxidase Mouse IgG2b 59A5 Supernatant Hu P
1 ml / €450.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Myeloperoxidase Mouse IgG2b 59A5 Supernatant Hu P
0.5 ml / €300.00
  Acris Antibodies GmbH

Myeloperoxidase (1-193) antibody

Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 9B12G7 Ascites Hu E, IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Myeloperoxidase antibody

Myeloperoxidase Mouse IgG1 2D4 Biotin Ms, Rt C, E, ICC/IF
50 µg / €360.00
  Acris Antibodies GmbH

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