Myoglobin antibody

Principal name

Myoglobin antibody

Alternative names for Myoglobin antibody

MB

SwissProt ID

P02144 (Human), P02189 (Pig), P02190 (Sheep), P02192 (Bovin), P04247 (Mouse), P68082 (Horse), Q6VN46 (Danre), Q9QZ76 (Rat)

Gene ID

4151 (MB), 17189 (Mb), 59108, 4353 (MPO)

Available reactivities

Hu (Human), Can (Canine), Rt (Rat), Ms (Mouse)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), ELISA (detection) (E(detection)), ELISA (capture) (E(capture)), Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Lateral Flow (LF)

Background of Myoglobin antibody

Myoglobin (Mygb) is a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative skeletal muscle fibers and functions as facilitator of oxygen transport, storage of oxygen and a scavenger of nitric oxide or reactive oxygen species. Mygb and hemoglobin are the iron containing proteins that carry oxygen in the body. The heme group present in neuroglobin, Mygb, Hemoglobin, cytochrome b and many other heme containing proteins consist of a complex protoporphyrin ring bound with iron in the ferrous state. Myoglobin measurement is used in many clinical diagnoses and has become an important tool in prognosis and diagnosis of several diseases. Mygb is (M(r) 18,000) and fatty acid-binding protein (M(r) 15,000), are low molecular mass cytoplasmic proteins that are considered useful biochemical markers for early detection or exclusion of acute myocardial infarction, and also for early estimation of infarct size. As each of these proteins shows renal clearance, the influence of renal function on the estimation of infarct size from their plasma concentration curves can be drawn (1). Myoglobin plasma levels correlates with muscle wasting in patients with cancer-related cachexia. Myoglobin expression is increased in muscles in the presence of testosterone by aerobic exercises (1).
Hemoglobin and Mygb are among the most extensively studied proteins along with nitrite one of the most studied signal transducing small molecules. During the last decade, multiple physiological studies have surprisingly revealed that nitrite represents a biological reservoir of NO by R-type catalysis in the oxygen carrying process of hemoglobin and Mygb that can regulate hypoxic vasodilation, cellular respiration, and signaling (2). Carbon monoxide poisoning let to elevated levels of CO in blood, but its diffusion to other tissue and the tissue contents are difficult to measure and asses. Multi-compartment models for CO diffusion to muscle and other sub-compartments can be achieved by measuring CO contents in Myoglobin (3). Myoglobin is protoporphyrin containing iron-binding glycoprotein with an approximate molecular weight of 19kDa (154 amino acids). The protein has a porpyrin binding domains housing one Fe(3+) ion.

General readings

General / background references:Penttila K et al. Myoglobin, creatine kinase MB isoforms and creatine kinase MB mass in early diagnosis of myocardial infarction in patients with acute chest pain. Clin Biochem 35:647-53 (2002). PubMed PMID: 12499000
Srinivas VS et al. Myoglobin levels at 12 hours identify patients at low risk for 30-day mortality after thrombolysis in acute myocardial infarction: a Thrombolysis in Myocardial Infarction 10B substudy. Am Heart J 142:29-36 (2001). PubMed PMID: 11431653
Van Nieuwenhoven FA et al. Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein. Circulation 92:2848-54 (1995). PubMed PMID: 7586251
Kagen L et al. Serum myoglobin in myocardial infarction: the "staccato phenomenon." Is acute myocardial infarction in man an intermittent event? Am J Med 62:86-92 (1977). PubMed PMID: 835594

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Myoglobin antibody

AP15673PU Myoglobin antibody staining of Human Skeletal Muscle. Rabbit Purified Hu P, WB
0.5 ml / €300.00
  Acris Antibodies GmbH

Myoglobin antibody

AP15673PU Myoglobin antibody staining of Human Skeletal Muscle. Rabbit Purified Hu P, WB
1 ml / €330.00
  Acris Antibodies GmbH

Myoglobin antibody

AP15673PU Myoglobin antibody staining of Human Skeletal Muscle. Rabbit Purified Hu P, WB
0.1 ml / €170.00
  Acris Antibodies GmbH

Myoglobin antibody

Western blot analysis of extracts from Jurkat cells, using MB antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Myoglobin antibody

Myoglobin Antibody (Cat. #TA324349) western blot analysis in mouse heart and skeletal muscle tissue lysates (35ug/lane).This demonstrates the Myoglobin antibody detected the Myoglobin protein (arrow). Mouse IgG1 444CT19.2.1 Purified Hu, Mky, Ms, Por WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Myoglobin antibody

Immunohistochemistry staining of Paraffin Skeletal muscle tissue by Myoglobin antibody (dilution: 1:50 - 1:200; visualization of staining: Cytoplasmic) Rabbit Purified Hu P
1 ml / €420.00
  OriGene Technologies, Inc.

Myoglobin antibody

Western blot analysis of extracts of various cell lines, using MB antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Myoglobin antibody

Myoglobin Mouse IgG1 BDI572 Purified Hu E
1 mg / €400.00
  Acris Antibodies GmbH

Myoglobin antibody

Myoglobin Mouse IgG1 BDI927 Purified Hu E
1 mg / €400.00
  Acris Antibodies GmbH

Myoglobin antibody

Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue showing cytoplasmic localization using anti-Myoglobin antibody Cat.-No AM06141PU-N with DAB staining. Mouse IgG1 6H8B5 Purified Hu E, P, WB
0.1 ml / €360.00
  Acris Antibodies GmbH

Myoglobin antibody

Myoglobin Mouse IgG1 JAN-12 Purified Hu, Rt IP, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Myoglobin antibody

The extracts of mouse muscle and heart (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human MB antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 AT6E10 Purified Hu, Ms E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Myoglobin antibody

The extracts of mouse muscle and heart (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human MB antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 AT6E10 Purified Hu, Ms E, WB
50 µl / €230.00
  Acris Antibodies GmbH

Myoglobin Control Peptide

Myoglobin
0.25 mg / €250.00
  Acris Antibodies GmbH

Myoglobin antibody

Western blot with AP10163PU-N at 1:1000. Rabbit Aff - Purified Hu C, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Myoglobin antibody

Formalin-Fixed, Paraffin-Embedded Human skeletal muscle stained with Myoglobin antibody Cat.-No. AP10436PU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of skeletal muscle fibers. Rabbit Purified Hu P
1 ml / €290.00
  Acris Antibodies GmbH

Myoglobin antibody

Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu P, WB
0.25 ml / €470.00
  Acris Antibodies GmbH

Myoglobin antibody

Myoglobin Rabbit Purified Ms C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Myoglobin antibody

Myoglobin Mouse IgG2b 8A10 Ig Fraction Hu E
0.2 mg / €370.00
  Acris Antibodies GmbH

Myoglobin antibody

Myoglobin Goat Aff - Purified Hu E, E(detection)
1 mg / €360.00
  Acris Antibodies GmbH

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