Myosin-9 / MYH9 antibody

Principal name

Myosin-9 / MYH9 antibody

Alternative names for Myosin-9 / MYH9 antibody

Myosin heavy chain 9, Myosin heavy chain, non-muscle IIa, Non-muscle myosin heavy chain IIa, Cellular myosin heavy chain, type A, Non-muscle myosin heavy chain A

SwissProt ID

P14105 (Chick), P35579 (Human), Q258K2 (Canfa), Q62812 (Rat), Q8VDD5 (Mouse)

Gene ID

4627 (MYH9)

Available reactivities

Can (Canine), Hu (Human), Rt (Rat), Ms (Mouse), Chk (Chicken), Por (Porcine), Macaque

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Myosin-9 / MYH9 antibody

Myosins belong to a superfamily of actin based motor proteins comprising to date at least 15 classes. There are two main groups of myosins: the conventional (class II) and the unconventional myosins. Myosin IIB (nonmuscle) is a relatively abundant, widespread two headed myosin composed of an N-terminal motor domain, a light chain binding neck region, a coiled coil region, and a nonhelical C-terminal domain. It forms a heterohexamer composed of a pair of heavy chains and two pairs of light chains. The vertebrate myosin II class members include muscle (sarcomeric and smooth) and nonmuscle (cytoplasmic) myosins. The non muscle myosin II class contains two isoforms: IIA and IIB, which exhibit 85% and 72% amino acid identity in the motor domain and the rod, respectively. Varying ratios of the two isoforms are expressed in different cells and tissues. Some cells express only a single isotype: e.g. myosin IIA in human platelets, rat basophilic leukemia cells, and chicken intestinal epithelium and myosin IIB in embryonic cardiac myocytes and COS-7 cells. The two isoforms vary in their intracellular localization, enzymatic activities, and proposed functions. Three additional isoforms of IIB have been described in neurons. Another isoform, myosin IIC, seems to constitute a distinct third isoform of the nonmuscle myosins. Nonmuscle myosin II is involved in cell motility and adhesion, cytokinesis, vesicular transport, intracellular force generation, and in morphogenesis during development. Its activity is regulated by light chain and possibly heavy chain phosphorylation and by association with proteins such as Mts1. Lethal defects in the development of the heart and hydrocephalus of the brain have been described in NMHCB homozygous knockout mice.

General readings

General / background references:Sellers JR Myosins: a diverse superfamily. Biochim Biophys Acta 1496:3-22 (2000). PubMed PMID: 10722873
Bresnick AR Molecular mechanisms of nonmuscle myosin-II regulation. Curr Opin Cell Biol 11:26-33 (1999). PubMed PMID: 10047526
Phillips CL et al. Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies. J Muscle Res Cell Motil 16:379-89 (1995). PubMed PMID: 7499478

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Myosin-9 / MYH9 antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 2B3 Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Myosin-9 / MYH9 antibody

Human Kidney, Glomeruli: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 4H3 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Myosin-9 / MYH9 antibody

Immunofluorescence of monoclonal antibody to MYH9 on A-431 cell . [antibody concentration 10 ug/ml] Mouse IgG2b 3C7 Purified Hu, Ms E, ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Myosin-9 / MYH9 antibody

MYH9 monoclonal antibody (M01), clone 3C7. Western Blot analysis of MYH9 expression in NIH/3T3 ( Cat # L018V1 ). Mouse IgG2b 3C7 Ascites Hu, Ms E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

Myosin-9 / MYH9 antibody

Detection limit for recombinant GST tagged MYH9 is approximately 0.03ng/ml as a capture antibody. Mouse IgG2b 2B3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Myosin-9 / MYH9 antibody

Detection limit for recombinant GST tagged MYH9 is approximately 0.3ng/ml as a capture antibody. Mouse IgG3 4D1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Myosin-9 / MYH9 antibody

Detection limit for recombinant GST tagged MYH9 is approximately 0.03ng/ml as a capture antibody. Mouse IgG1 1H6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Myosin-9 / MYH9 antibody

Immunoperoxidase of monoclonal antibody to MYH9 on formalin-fixed paraffin-embedded human ovary cancer. [antibody concentration 0.7 ug/ml] Mouse IgG2b 4H3 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Myosin-9 / MYH9 antibody

Human HEK293; MYH9 antibody - middle region (ARP48072_P050) validated by WB using Hek 293 Whole Cell Lysate at 1:4,000.; MYH9 antibody - middle region (ARP48072_P050) in Human HEK293 cells using Western Blot Rabbit Aff - Purified Can, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Myosin-9 / MYH9 antibody

Western blot analysis of Myosin 9 expression in A549 (A); rat testis (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Por, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Myosin-9 / MYH9 antibody

Western blot analysis of Myosin 9 expression in A549 (A); rat testis (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Por, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Myosin-9 / MYH9 antibody

Western blot analysis of Myosin 9 expression in A549 (A); rat testis (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Por, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Myosin-9 / MYH9 antibody

Myosin-9 / MYH9 Rabbit Aff - Purified Can, Hu, Rt ICC/IF, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Myosin-9 / MYH9 antibody

Myosin-9 / MYH9 Rabbit IgG Hu, Ms ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Myosin-9 / MYH9 antibody

Myosin-9 / MYH9 Rabbit IgG Hu WB
0.1 ml / €340.00
  Novus Biologicals Inc.

Myosin-9 / MYH9 antibody

Immunohistochemistry-Paraffin: non-muscle Myosin IIA Antibody [NBP1-85244] - Immunohistochemical staining of human kidney shows distinct cytoplasmic positivity in cells in glomeruli. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Myosin-9 / MYH9

Myosin-9 / MYH9 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Myosin-9 / MYH9

Myosin-9 / MYH9 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Myosin-9 / MYH9

Myosin-9 / MYH9 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

Myosin-9 / MYH9

Myosin-9 / MYH9 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

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