Myosin-Va antibody

Principal name

Myosin-Va antibody

Alternative names for Myosin-Va antibody

MYO5A, MYH12, Dilute myosin heavy chain, non-muscle, Myosin heavy chain 12, Myoxin

SwissProt ID

Q02440 (Chick), Q99104 (Mouse), Q9QYF3 (Rat), Q9Y4I1 (Human)

Gene ID

4644 (MYO5A)

Available reactivities

Chk (Chicken), Rt (Rat), Hu (Human), Ms (Mouse), Can (Canine), Por (Porcine), Bov (Bovine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Myosin-Va antibody

Myosin Va (p190) is a member of the unconventional class of myosins, distinct from both the myosins I and myosins II. It is present in neuronal and non neuronal cells of the brain. Class V myosins are widely expressed actin-based motors that have been implicated in the transport and/or localization of a wide range of organelles as well as mRNA. Class V myosins have two motor head domains typical of myosins, and an extended regulatory neck domain with six tandem IQ domains that bind multiple calmodulin light chains. In addition, myosin V contains a unique 400 amino acids globular tail domain that may direct myosin V to its target or determine the cargo to which it binds. Brain myosin Va exhibits an unusually high affinity for F-actin. In the presence of ATP, its Mg-ATPase activity is stimulated by physiological Ca2+ concentrations in a highly cooperative manner. Based on biochemical properties, kinetic and optical measurements, it has been suggested that myosin Va is a processive, actinbased molecular motor. Myosin Va has been implicated in the regulation of vesicle trafficking in neurons and melanocytes. It has been suggested that class V myosins associate with membrane vesicles through their C-terminal tails. Myosin V associates with synaptic vesicles and forms a stable complex with the synaptic vesicle membrane proteins, synaptobrevin II, and synaptophysin. The dilute Myo5a gene mutation in myosin Va leads to mental retardation, variable cellular immunodeficiency and impaired melanocyte function (pigmentary dilution), known as Griscelli syndrome in humans. Myosin Va regulates melanosome distribution along microfilaments. It is found in association with the centrosome at all stages of the cell cycle. In the interphase stage, myosin Va is found in pericentriolar material. During cell division, it is found in the cytoplasm and concentrates in a trail between migrating centrioles and in the mitotic spindle poles and spindle fibers.

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Myosin-Va antibody

(1ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Myosin-Va antibody

Western blot analysis of extracts from HeLa cells, using MYO5A antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Myosin-Va antibody

Myosin-Va Goat Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Myosin-Va antibody

Immunohistochemistry-Paraffin: MYO5 Antibody [NBP1-92156] Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Myosin-Va

Myosin-Va Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Myosin-Va

Myosin-Va Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

6 Item(s)

per page
  • LinkedIn