Myostatin antibody

Principal name

Myostatin antibody

Alternative names for Myostatin antibody

MSTN, GDF8, GDF-8, Growth differentiation factor 8

SwissProt ID

O08689 (Mouse), O14793 (Human), O18830 (Sheep), O18831 (Pig), O18836 (Bovin), O35312 (Rat)

Gene ID

2660 (MSTN), 17700 (Mstn)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Gt (Goat), Por (Porcine), Rb (Rabbit), Sh (Sheep), Ze (Zebrafish)

Available hosts

Chicken, Mouse, Rabbit, Goat, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Functional assay (FN)

Background of Myostatin antibody

Myostatin (GDF8) is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor ß superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology.
In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.

General readings

1. McPherron AC, Lee SJ.
2. Jiang MS, Liang LF, Wang S, Ratovitski T, Holmstrom J, Barker C, Stotish R. Characterization and identification of the inhibitory domain of GDF-8 propeptide.
3. McPherron A.C. and Lee S.J. Double muscling in cattle due to mutations in the myostatin gene.
4. Thies RS, Chen T, Davies MV, Tomkinson KN, Pearson AA, Shakey QA, Wolfman NM. GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor
binding.
5. Taylor WE, Bhasin S, Artaza J, Byhower F, Azam M, Willard DH Jr, Kull FC Jr, Gonzalez-Cadavid N. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells.
6. Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP, Fareez MM, Gonzalez-Cadavid NF. Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T (1/2) mesenchymal multipotent cells. Endocrinology.
7. Sharma M. et al. Myostatin, a transforming growth factor beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct.
8. Sharma M, Kambadur R, Matthews KG, Somers WG, Devlin GP, Conaglen JV, Fowke PJ, Bass JJ. Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct.
9. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, Shen R, Lalani R, Asa S, Mamita M, Nair G, Arver S, Bhasin S. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.
10. Gonzalez Cadavid N.F., Taylor W.E. et al. Organization of the human myostatin gene and expression in heathy men and HIV infected men with muscle wasting.
11. Lee SJ, McPherron AC. Regulation of myostatin activity and muscle growth.
12. Hill JJ, Davies MV, Pearson AA, Wang JH, Hewick RM, Wolfman NM, Qiu Y. The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum.

Items 1 to 20 of 58 total

per page
Page:
  1. 1
  2. 2
  3. 3

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Myostatin (24-39) antibody

Anti-MSTN / Myostatin antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Rabbit Purified Hu E, P
50 µg / €345.00
  OriGene Technologies, Inc.

Myostatin antibody

Predicted cell location: Cytoplasm. Positive control: Human breast and lung cancer tissue. Recommended dilution: 1/5-20  The image on the left is immunohistochemistry of paraffin-embedded Human breast and lung cancer tissue using MSTN antibody at dilution 1/8, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Myostatin antibody

Host: Rabbit; Target Name: Mstn; Sample Tissue: Mouse Brain lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Myostatin antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MSTN (RC210368, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MSTN.(1:2000) Mouse IgG1 OTI7H5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Myostatin antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MSTN (RC210368, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MSTN.(1:2000) Mouse IgG2b OTI4F9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Myostatin antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MSTN (RC210368, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MSTN.(1:2000) Mouse IgG1 OTI6A7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Myostatin antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MSTN (RC210368, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MSTN.(1:2000) Mouse IgG2b OTI3A7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Myostatin antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MSTN (RC210368, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MSTN.(1:500) Mouse IgG1 OTI2D10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Myostatin antibody

Myostatin Mouse IgG2b 7F Purified Hu E
0.1 mg / €450.00
  Acris Antibodies GmbH

Myostatin antibody

Myostatin Mouse IgG2b 7F Purified Hu E
10 µg / €140.00
  Acris Antibodies GmbH

Myostatin antibody

Myostatin Mouse IgG2b 4D Purified Hu E
0.1 mg / €450.00
  Acris Antibodies GmbH

Myostatin antibody

Myostatin Mouse IgG2b 4D Purified Hu E
10 µg / €140.00
  Acris Antibodies GmbH

Myostatin antibody

Western blot analysis using Myostatin mouse mAb against truncated Myostatin-His recombinant protein (1). Mouse IgG1 6H12 Ascites Hu WB
0.1 ml / €360.00
  Acris Antibodies GmbH

Myostatin antibody

Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 6H12 Ascites Hu E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Myostatin (53-66) antibody

Myostatin Rabbit Serum Hu E
0.1 ml / €450.00
  Acris Antibodies GmbH

Myostatin (53-66) antibody

Myostatin Rabbit Serum Hu E
20 µl / €180.00
  Acris Antibodies GmbH

Myostatin (79-92) antibody

Myostatin Rabbit Serum Hu E
0.1 ml / €450.00
  Acris Antibodies GmbH

Myostatin (79-92) antibody

Myostatin Rabbit Serum Hu E
20 µl / €180.00
  Acris Antibodies GmbH

Myostatin (83-98) antibody

Myostatin Rabbit Serum Hu E
0.1 ml / €450.00
  Acris Antibodies GmbH

Myostatin (83-98) antibody

Myostatin Rabbit Serum Hu E
20 µl / €180.00
  Acris Antibodies GmbH

Items 1 to 20 of 58 total

per page
Page:
  1. 1
  2. 2
  3. 3
  • LinkedIn