Myotubularin / MTM1 antibody

Principal name

Myotubularin / MTM1 antibody

SwissProt ID

A6QLT4 (Bovin), Q13496 (Human), Q6AXQ4 (Rat), Q9Z2C5 (Mouse)

Gene ID

4534 (MTM1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Can (Canine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Myotubularin / MTM1 antibody

X-linked recessive myotubular myopathy is a congenital muscular disease characterized by severe hypotonia and generalized muscle weakness that,in most cases, leads to early postnatal death. The gene responsible for myotubular myopathy MTM1 encodes a dual specificity phosphatase, named myotubularin, which is highly conserved through evolution. The gene for MTM1 is localized to a 300 kb critical region on human Xq128 between IDS and GRBRA3. Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.

General readings

Laporte J, Hu LJ, Kretz C, Mandel JL, Kioschis P, Coy JF, Klauck SM, Poustka A, Dahl N. A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast. Nat Genet. 1996 Jun;13(2):175-82.
PMID: 8640223

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Myotubularin / MTM1 antibody

MTM1 MaxPab rabbit polyclonal antibody. Western Blot analysis of MTM1 expression in mouse liver. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Myotubularin / MTM1 antibody

Immunoperoxidase of monoclonal antibody to MTM1 on formalin-fixed paraffin-embedded human pancreas. [antibody concentration 3 ug/ml] Mouse IgG2a 1C10 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Myotubularin / MTM1 (C-term) antibody

TA302542 (0.3µg/ml) staining of HepG2 lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Myotubularin / MTM1 (C-term) antibody

The anti-MTM1 C-term Pab is used in Western blot to detect MTM1 in NCI-H460 cell lysate (lane 1) and in mouse heart tissue lysate (lane 2). Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Myotubularin / MTM1 antibody

Myotubularin / MTM1 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

Myotubularin / MTM1 antibody

The MTM1 polyclonal antibody ( Cat # PAB4507 ) is used in Western blot to detect MTM1 in mouse heart tissue lysate . Rabbit Hu, Ms E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Myotubularin / MTM1 antibody

MTM1 polyclonal antibody ( Cat # PAB6061 ) staining ( 0.3 µg/ml ) of HepG2 lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Myotubularin / MTM1 antibody

Western blot analysis of Myotubularin expression in HepG2 (A) whole cell lysates. Rabbit Aff - Purified Hu, Ms WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Myotubularin / MTM1 antibody

Western blot analysis of Myotubularin expression in HepG2 (A) whole cell lysates. Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Myotubularin / MTM1 antibody

Western blot analysis of Myotubularin expression in HepG2 (A) whole cell lysates. Rabbit Aff - Purified Hu, Ms WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Myotubularin / MTM1 antibody

Western Blot:Myotubularin Antibody - HEK293 overexpressing Myotubularin (RC205306) and probed (mock transfection in first lane), tested by Origene. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Myotubularin / MTM1 antibody

Myotubularin / MTM1 Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Myotubularin / MTM1 antibody

Immunohistochemistry-Paraffin: MTM1 Antibody [NBP1-86107] - Immunohistochemical staining of human skeletal muscle shows moderate cytoplasmic positivity in myocytes. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Myotubularin / MTM1 antibody

Immunohistochemistry-Paraffin: MTM1 Antibody [NBP1-86113] - Immunohistochemical staining of human duodenum shows strong cytoplasmic and membranous positivity in glandular cells (goblet cells). Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Myotubularin / MTM1

Myotubularin / MTM1 Human
2 µg / €300.00
  Abnova Taiwan Corp.

Myotubularin / MTM1

Myotubularin / MTM1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Myotubularin / MTM1

Myotubularin / MTM1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Myotubularin / MTM1

Myotubularin / MTM1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Myotubularin / MTM1

Myotubularin / MTM1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MTM1 293T Cell Transient Overexpression Lysate(Denatured)

MTM1 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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