NACC1 / BTBD14B antibody

Principal name

NACC1 / BTBD14B antibody

Alternative names for NACC1 / BTBD14B antibody

NAC1, Nucleus accumbens-associated protein 1, BTB/POZ domain-containing protein 14B

SwissProt ID

O35260 (Rat), Q7TSZ8 (Mouse), Q96RE7 (Human)

Gene ID

112939 (NACC1), 66830 (Nacc1), 171454

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C)

Background of NACC1 / BTBD14B antibody

NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors . NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system . NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene . The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway . NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 . Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer .

General readings

Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH.
A protein interaction network for pluripotency of embryonic stem cells.
Nature. 2006 Nov 16;444(7117):364-8. Epub 2006 Nov 8.
PMID: 17093407

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NACC1 / BTBD14B antibody

  Goat Polyclonal Antibody against BTBD14B  
TA303211 (0.5µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

  Mouse Monoclonal Nac1 Antibody (3)  
Western Blot: Nac1 Antibody (3) - Detection of NAC-1 in HeLa nuclear extracts using anti-NAC1. Mouse Purified Hu C, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

  Rabbit Polyclonal anti-Nac1 Antibody  
Human stem cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with purified rabbit polyclonal anti-Nac1 antibody, proteins were visualized by HRP conjugated anti-rabbit secondary antibody and a chemiluminescence system. Rabbit IgG Poly6404 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

  Rabbit Polyclonal Anti-BTBD14B Antibody  
WB Suggested Anti-BTBD14B Antibody Titration: 2.5 ug/ml; ELISA Titer: 1:312500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

  Rabbit Polyclonal Anti-NACC1 Antibody  
WB Suggested Anti-BTBD14B Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: 721_B cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

  Rabbit Polyclonal Anti-BTBD14B Antibody  
WB Suggested Anti-BTBD14B Antibody Titration: 5.0 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and ovarian cancer tissues (right) using NACC1 antibody Cat.-No AM06551SU-N with DAB staining. Mouse IgG1 6H2 Ascites Hu E, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NACC1 - human gene knockout kit via CRISPR

NACC1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NACC1 - human gene knockout kit via CRISPR

NACC1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NACC1 - human gene knockout kit via CRISPR

NACC1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NACC1 - human gene knockout kit via CRISPR

NACC1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nacc1 - mouse gene knockout kit via CRISPR

Nacc1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Nacc1 - mouse gene knockout kit via CRISPR

Nacc1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nacc1 - mouse gene knockout kit via CRISPR

Nacc1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nacc1 - mouse gene knockout kit via CRISPR

Nacc1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NACC1 (mGFP-tagged)-Human nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (NACC1), 200 uL, >10^7 TU/mL

Lenti ORF particles, NACC1 (mGFP-tagged)-Human nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (NACC1), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, NACC1 (Myc-DDK-tagged)-Human nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (NACC1), 200 uL, >10^7 TU/mL

Lenti ORF particles, NACC1 (Myc-DDK-tagged)-Human nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (NACC1), 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Nacc1 (GFP-tagged) - Mouse nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (Nacc1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Nacc1 (GFP-tagged) - Mouse nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (Nacc1), 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, Nacc1 (Myc-DDK-tagged) - Mouse nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (Nacc1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Nacc1 (Myc-DDK-tagged) - Mouse nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (Nacc1), 200 uL, >10^7 TU/mL  
200 µl / €1,020.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Nacc1 (GFP-tagged ORF) - Rat nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (Nacc1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Nacc1 (GFP-tagged ORF) - Rat nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (Nacc1), 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

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