NACC1 / BTBD14B antibody

Principal name

NACC1 / BTBD14B antibody

Alternative names for NACC1 / BTBD14B antibody

NAC1, Nucleus accumbens-associated protein 1, BTB/POZ domain-containing protein 14B

SwissProt ID

O35260 (Rat), Q7TSZ8 (Mouse), Q96RE7 (Human)

Gene ID

112939 (NACC1), 5112939 (IPR002500)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C)

Background of NACC1 / BTBD14B antibody

NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors . NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system . NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene . The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway . NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 . Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer .

General readings

Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH.
A protein interaction network for pluripotency of embryonic stem cells.
Nature. 2006 Nov 16;444(7117):364-8. Epub 2006 Nov 8.
PMID: 17093407

19 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NACC1 / BTBD14B antibody

TA303211 (0.5µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

Western Blot: Nac1 Antibody (3) - Detection of NAC-1 in HeLa nuclear extracts using anti-NAC1. Mouse Purified Hu C, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

Human stem cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with purified rabbit polyclonal anti-Nac1 antibody, proteins were visualized by HRP conjugated anti-rabbit secondary antibody and a chemiluminescence system. Rabbit IgG Poly6404 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

WB Suggested Anti-BTBD14B Antibody Titration: 2.5 ug/ml; ELISA Titer: 1:312500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

WB Suggested Anti-BTBD14B Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: 721_B cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

WB Suggested Anti-BTBD14B Antibody Titration: 5.0 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NACC1 / BTBD14B antibody

Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and ovarian cancer tissues (right) using NACC1 antibody Cat.-No AM06551SU-N with DAB staining. Mouse IgG1 6H2 Ascites Hu E, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

NACC1 / BTBD14B antibody

Immunohistochemistry of NACC1 monoclonal antibody, clone 3 ( Cat # MAB2333 ).
Nuclear staining of paraffin-embedded ovarian cancer cells. Mouse 3 Hu ICC/IF, IP, P, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

NACC1 / BTBD14B antibody

NACC1 polyclonal antibody ( Cat # PAB7239 ) ( 0.5 µg/ml ) staining of human bone marrow lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

NACC1 / BTBD14B antibody

Human Lung; BTBD14B antibody - middle region (ARP34614_T100) in Human Lung cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

NACC1 / BTBD14B antibody

Human 721_B; WB Suggested Anti-BTBD14B Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: 721_B cell lysate; BTBD14B antibody - middle region (ARP34653_P050) in Human 721_B cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

NACC1 / BTBD14B antibody

Human Intestine; BTBD14B antibody - C-terminal region (ARP39772_T100) in Human Intestine cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

NACC1 / BTBD14B antibody

Western Blot: BTBD14B Antibody [NB100-58964] - NB100-58964 (0.5ug/ml) staining of Human Bone Marrow lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

NACC1 / BTBD14B antibody

NACC1 / BTBD14B Mouse 3 Biotin Hu ICC/IF, IP, P, WB
0.1 ml / €360.00
  Novus Biologicals Inc.

NACC1 / BTBD14B antibody

NACC1 / BTBD14B Mouse 3 DyLight488 Hu ICC/IF, IP, P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

NACC1 / BTBD14B antibody

NACC1 / BTBD14B Mouse 3 HRP Hu ICC/IF, IP, P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

NACC1 / BTBD14B antibody

NACC1 / BTBD14B Mouse 3 Purified Hu ICC/IF, IP, P, WB
25 µl / €160.00
  Novus Biologicals Inc.

NACC1 / BTBD14B antibody

Immunohistochemistry-Paraffin: Nac1 Antibody (6H2) [NBP1-51681] - Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and ovarian cancer tissues (right) using NACC1 mouse mAb with DAB staining. Mouse IgG1 6H2 Purified Hu E, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

NACC1 / BTBD14B antibody

Immunohistochemistry-Paraffin: Nac1 Antibody [NBP1-89991] - Immunohistochemical staining of human urinary bladder shows strong nuclear positivity in urothelial cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

19 Item(s)

per page
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