NAF1 antibody

Principal name

NAF1 antibody

Alternative names for NAF1 antibody

H/ACA ribonucleoprotein complex non-core subunit NAF1

Gene ID

92345 (NAF1)

Available reactivities

Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP)

Background of NAF1 antibody

This 5C4 monoclol antibody reacts with human Nef-associated factor-1 (f-1). This protein is also desigted as A20-binding inhibitor of NFkB activation (ABIN-1) and TNFAIP3-interacting protein 1 (TNIP1). f-1 is predicted to consist of four leucine zippers and four coiled-coil domains. This protein exists as two isoforms, f1α and f1β, which are 72-kDa and 68-kDa, respectively, and is expressed in a variety of tissues, with greatest expression in peripheral blood lymphocytes, spleen, and skeletal muscle. f1 has also been detected in the Jurkat, Molt-4, and HL60 cell lines.f-1 has been shown to play several biological roles. f-1 was origilly identified associated with the Nef protein of HIV, and was found to enhance CD4 cell surface expression. f-1 has also been demonstrated to inhibit TNF-α- and IL-1-mediated NFkB-dependent gene expression by competing with IKK-γ. Filly, this adaptor protein has been found to associate constitutively with P-selectin glycoprotein ligand 1 (PSGL-1) in human leukocytes. Upon P-selectin binding to PSGL-1, f1 is phosphorylated at Tyr552 by Src family kises, leading to PI3K recruitment and integrin activation. This antibody recognizes both the unphosphorylated and phosphorylated forms of f1α and f1β.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NAF1 antibody

NAF1 Mouse 5C4 Purified Hu IP, P, WB
  OriGene Technologies, Inc.

NAF1 antibody

NAF1 Mouse Hu WB
  Abnova Taiwan Corp.

NAF1 antibody

NAF1 Rabbit IgG Aff - Purified Hu ICC/IF, P
  Novus Biologicals Inc.

3 Item(s)

per page
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