NALCN / VGCNL1 antibody

Principal name

NALCN / VGCNL1 antibody

Alternative names for NALCN / VGCNL1 antibody

CanIon, Sodium leak channel non-selective protein, Voltage gated channel-like protein 1

SwissProt ID

Q6Q760 (Rat), Q8BXR5 (Mouse), Q8IZF0 (Human)

Gene ID

259232 (NALCN), 266760 (Nalcn), 338370

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of NALCN / VGCNL1 antibody

The existence of resting K+ conductance has been known for some time. Only recently has the lcn (sodium leak channel non-selective protein) has been found responsible for the resting + conductance. lcn is a member of the V and CaV channels family which have four homologous repeats of six transmembrane domains. One structural difference is that lcn is less positively charged in the voltage sensing segment. The protein forms voltage-independent non-ictivating channel which is permeable to +, K+ and Ca2+ ions. Evidence suggests that lcn is a non-redundant and thus essential channel since knock-out mice display disrupted respiratory rhythm and die with 24 hours of birth. In addition, isolated neurons from these mice have decreased excitability. The channel is extensively expressed in the central nervous system, heart, pituitary and adrel glands and pancreatic islet cells. In pancreatic islets, lcn is activated by acetylcholine via its physical association with M3 muscarinic receptor, and potentiates insulin secretion induced by glucose uptake.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NALCN / VGCNL1 (1659-1738, Cytopl. Dom.) antibody

NALCN / VGCNL1 Mouse IgG1 S185-7 Purified Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NALCN / VGCNL1 antibody

Western blot analysis of rat brain (lanes 1 and 4), mouse heart (lanes 2 and 5) and SH-SYS5 (lanes 3 and 6) lysates: 1-3. Anti-Sodium Leak Channel Non-Selective Protein (Nalcn) (extracellular) antibody , (1:200). 4-6. Anti-Sodium Leak Channel Non-Selective Protein (Nalcn) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

NALCN / VGCNL1 antibody

Adult rat brain membrane immunoblot Mouse IgG1 N185/7 Supernatant Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

NALCN / VGCNL1 antibody

Adult rat brain membrane immunoblot Mouse IgG1 N185/7 Purified Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

NALCN / VGCNL1 antibody

NALCN / VGCNL1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

CRISPR

Catalog No. Species Donor Vector  

NALCN - human gene knockout kit via CRISPR

NALCN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NALCN - human gene knockout kit via CRISPR

NALCN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NALCN - human gene knockout kit via CRISPR

NALCN - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NALCN - human gene knockout kit via CRISPR

NALCN - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nalcn - mouse gene knockout kit via CRISPR

Nalcn - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Nalcn - mouse gene knockout kit via CRISPR

Nalcn - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nalcn - mouse gene knockout kit via CRISPR

Nalcn - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nalcn - mouse gene knockout kit via CRISPR

Nalcn - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NALCN (Myc-DDK tagged) - Human sodium leak channel, non-selective (NALCN), 200 uL, >10^7 TU/mL

Lenti ORF particles, NALCN (Myc-DDK tagged) - Human sodium leak channel, non-selective (NALCN), 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

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