NALP3 antibody

Principal name

NALP3 antibody

Alternative names for NALP3 antibody

NLRP3, C1orf7, CIAS1, PYPAF1, NACHT, LRR and PYD domains-containing protein 3

SwissProt ID

Q8R4B8 (Mouse), Q96P20 (Human)

Gene ID

114548 (NLRP3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Mky (Monkey), Prim (Primate)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C), Dot blot (Dot)

Background of NALP3 antibody

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 3 encode the same isoform. Sequence Note: This RefSeq contains an alternative downstream translation start codon, which would result in a protein that is 2 aa shorter at the N-terminus. The residue coordinates referred to in the literature, including PMIDs:11687797, 11786556 and 12522564, are based on the use of the downstream start codon. No experimental evidence exists to show which start codon is preferentially used. The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

1. Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet. 2001 Nov;29(3):301-5.
PMID: 11687797

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NALP3 antibody

AP32694PU-N (2 µg/ml) staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

NALP3 antibody

Sample(30 ug of whole cell lysate). A:Raji. 7.5% SDS PAGE. TA309046 diluted at 1:1500 Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NALP3 antibody

Predicted cell location: Cytoplasm. Positive control: Human esophagus and thyroid cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human esophagus cancer tissue using NLRP3 antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NALP3 antibody

Western Blot: NALP3 Antibody (25N10E9) [TA336883] - Analysis using the NALP3 monoclonal antibody. (A), (B), mouse RAW lysate © and the recombinant mouse NLRP3 NOD domain protein immunogen (D) probed with 2 ug/ml antibody. goat anti-mouse Ig HRP s Mouse IgG2b 25N10E9 Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NALP3 antibody

Western Blot: NALP3 Antibody [TA336895] - Analysis of NALP3 using NALP3 antibody. Human testis lysate in the 1) absence, 2) presence of immunizing peptide, 3) mouse and 4) rat testis probed with NALP3 antibody at 5, 2 and 2 ug/ml respectively. goat anti-r Rabbit Purified Hu, Ms, Prim, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NALP3 (N-term) antibody

Western blot analysis of NLRP3 Antibody (N-term) (AP18137PU-N) in MDA-MB231 cell line lysates (35ug/lane).NLRP3 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

NALP3 (C-term) antibody

AP22372PU-N NLRP3 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Peripheral Blood Leukocytes at 2.5 µg/ml using Biotinylated anti-Goat IgG secondary antibody, Alkaline Phosphatase-Streptavidin and chromogen. Goat Aff - Purified Bov, Hu, Rt E, F
0.1 mg / €340.00
  Acris Antibodies GmbH

NALP3 antibody

NALP3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

NALP3 antibody

Western Blot analysis of NLRP3 expression in transfected 293T cell line (H00114548-T01) by NLRP3 MaxPab polyclonal antibody.

Lane 1: CIAS1 transfected lysate(113.96 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

NALP3 antibody

Western Blot analysis of NLRP3 expression in transfected 293T cell line (H00114548-T02) by NLRP3 MaxPab polyclonal antibody.

Lane 1: NLRP3 transfected lysate(118.20 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

NALP3 antibody

Western Blot analysis of CIAS1 expression in transfected 293T cell line by CIAS1 monoclonal antibody (M01), clone 3B1.

Lane 1: CIAS1 transfected lysate(118.2 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 3B1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

NALP3 antibody

Immunofluorescence microscopy showing the detection of endogenous NLRP3 in THP-1 cells with NLRP3 monoclonal antibody, clone Nalpy3-a ( Cat # MAB3723 ). Mouse IgG1 Nalpy3-a Hu ICC/IF, WB
0.1 mg / €640.00
  Abnova Taiwan Corp.

NALP3 antibody

NALP3 Mouse IgG1 Nalpy3-b Hu C, IP, WB
0.1 mg / €640.00
  Abnova Taiwan Corp.

NALP3 antibody

NALP3 Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

NALP3 antibody

NALP3 Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

NALP3 antibody

NALP3 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

NALP3 antibody

NALP3 Goat IgG Aff - Purified Hu E
0.1 mg / €320.00
  Novus Biologicals Inc.

NALP3 antibody

Western Blot: NALP3 Antibody [NBP1-31245] - Western blot analysis of NALP3 Antibody on: A:Raji 7.5% SDS PAGE diluted at 1:1500 Rabbit IgG Hu Dot, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

NALP3 antibody

Immunofluorescence: NALP3 Antibody [NBP1-77080] - K562 cells with NALP3 antibody at 20 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

NALP3 antibody

Immunohistochemistry-Paraffin: NALP3 Antibody [NBP1-90206] - Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

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